2019年，《Cell Research》发表甘露特钠疗效机制，研究者提出了一个全新假说：AD的发生与发展，源于肠道菌群紊乱—免疫失衡—神经炎症这一连锁反应；甘露特钠可通过调节肠道菌群，减少脑部炎症，从而改善认知功能，即“脑肠轴机制”。

这一发现引发国际关注，让世界重新认识了肠道菌群在中枢神经系统中的核心地位，至今已被引录1000余次。美国神经学协会主席、华盛顿大学David M. Holtzman 教授等发表述评认为，这一靶向肠道菌群治疗AD 的新策略为抗AD 药物的研发提供了全新思路。同年底甘露特钠发明人被《Nature》杂志评为5位“2020年关注人物”之一。

Cell Research全文链接： https://www.nature.com/articles/s41422-019-0216-x

以下为甘露特钠被引用的部分论文列表:

1．Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, Chang S, Gong Y, Ruan L, Zhang G, Yan S, Lian W, Du C, Yang D, Zhang Q, Lin F, Liu J, Zhang H, Ge C, Xiao S, Ding J, Geng M. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019 Oct;29(10):787-803. doi: 10.1038/s41422-019-0216-x. Epub 2019 Sep 6. PMID: 31488882; PMCID: PMC6796854.

2．Hole KL, Williams RJ. Flavonoids as an Intervention for Alzheimer's Disease: Progress and Hurdles Towards Defining a Mechanism of Action. Brain Plast. 2021 Feb 9;6(2):167-192. doi: 10.3233/BPL-200098. Erratum in: Brain Plast. 2024 May 14;9(1-2):97. doi: 10.3233/BPL-239000. PMID: 33782649; PMCID: PMC7990465.

3．Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024 Aug 23;9(1):211. doi: 10.1038/s41392-024-01911-3. PMID: 39174535; PMCID: PMC11344989.

4．Zhao Y, Ma S, Liang L, Cao S, Fan Z, He D, Shi X, Zhang Y, Liu B, Zhai M, Wu S, Kuang F, Zhang H. Gut Microbiota-Metabolite-Brain Axis Reconstitution Reverses Sevoflurane-Induced Social and Synaptic Deficits in Neonatal Mice. Research (Wash D C). 2024 Sep 19;7:0482. doi: 10.34133/research.0482. PMID: 39301264; PMCID: PMC11411162.

5．Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF. Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity. Front Aging Neurosci. 2021 Mar 1;13:633495. doi: 10.3389/fnagi.2021.633495. PMID: 33732137; PMCID: PMC7957014.

6．Zou Y, Ro KS, Jiang C, Yin D, Zhao L, Zhang D, Du L, Xie J. The anti- hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory strain, Lactiplantibacillus plantarum X7022. Eur J Nutr. 2024 Apr;63(3):697-711. doi: 10.1007/s00394-023-03291-w. Epub 2023 Dec 26. Erratum in: Eur J Nutr. 2024 Aug;63(5):1997. doi: 10.1007/s00394-024-03382-2. PMID: 38147149.

7．Morais LH, Schreiber HL 4th, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021 Apr;19(4):241-255. doi: 10.1038/s41579-020-00460-0. Epub 2020 Oct 22. PMID: 33093662.

8．Bai J, Wan Z, Zhang Y, Wang T, Xue Y, Peng Q. Composition and diversity of gut microbiota in diabetic retinopathy. Front Microbiol. 2022 Aug 23;13:926926. doi: 10.3389/fmicb.2022.926926. PMID: 36081798; PMCID: PMC9445585.

9．Fang EF, Xie C, Schenkel JA, Wu C, Long Q, Cui H, Aman Y, Frank J, Liao J, Zou H, Wang NY, Wu J, Liu X, Li T, Fang Y, Niu Z, Yang G, Hong J, Wang Q, Chen G, Li J, Chen HZ, Kang L, Su H, Gilmour BC, Zhu X, Jiang H, He N, Tao J, Leng SX, Tong T, Woo J. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev. 2020 Dec;64:101174. doi: 10.1016/j.arr.2020.101174. Epub 2020 Sep 21. PMID: 32971255; PMCID: PMC7505078.

10．Xie J, Zhong C, Wang T, He D, Lu L, Yang J, Yuan Z, Zhang J. Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version. Front Pharmacol. 2022 Jun 27;13:937075. doi: 10.3389/fphar.2022.937075. PMID: 35833035; PMCID: PMC9271619.

11．Xu Y, Jiang C, Wu J, Liu P, Deng X, Zhang Y, Peng B, Zhu Y. Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer's disease. CNS Neurosci Ther. 2022 Apr;28(4):580-592. doi: 10.1111/cns.13779. Epub 2021 Dec 10. PMID: 34889516; PMCID: PMC8928920.

12．Liu W, Fan M, Lu W, Zhu W, Meng L, Lu S. Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner. Front Immunol. 2022 Jun 30;13:872167. doi: 10.3389/fimmu.2022.872167. PMID: 35844577; PMCID: PMC9280647.

13．Liu X, Liu Y, Liu J, Zhang H, Shan C, Guo Y, Gong X, Cui M, Li X, Tang M. Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence. Neural Regen Res. 2024 Apr;19(4):833-845. doi: 10.4103/1673-5374.382223. PMID: 37843219; PMCID: PMC10664138.

14．Chu J, Zhang W, Liu Y, Gong B, Ji W, Yin T, Gao C, Liangwen D, Hao M, Chen C, Zhuang J, Gao J, Yin Y. Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease. Neural Regen Res. 2024 Jan;19(1):100-115. doi: 10.4103/1673-5374.374137. PMID: 37488851; PMCID: PMC10479833.

15．Hayashi Y, Lin HT, Lee CC, Tsai KJ. Effects of neural stem cell transplantation in Alzheimer's disease models. J Biomed Sci. 2020 Jan 27;27(1):29. doi: 10.1186/s12929-020-0622-x. PMID: 31987051; PMCID: PMC6986162.

16．Fülöp T, Munawara U, Larbi A, Desroches M, Rodrigues S, Catanzaro M, Guidolin A, Khalil A, Bernier F, Barron AE, Hirokawa K, Beauregard PB, Dumoulin D, Bellenger JP, Witkowski JM, Frost E. Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease. CNS Drugs. 2020 Jul;34(7):673-695. doi: 10.1007/s40263-020-00737-1. PMID: 32458360; PMCID: PMC9020372.

17．Xu Y, Liu H, Han D, Ren L, Gong X, Jiang F, Cui Y, Liu X, Ren C, Xue J, Tian X. Metabolomic Alterations in the Digestive System of the Mantis ShrimpOratosquilla oratoria Following Short-Term Exposure to Cadmium. Front Physiol. 2021 Aug 5;12:706579. doi: 10.3389/fphys.2021.706579. PMID: 34421644; PMCID: PMC8374601.

18．Ruan S, Zhai L, Wu S, Zhang C, Guan Q. SCFAs promote intestinal double- negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome. Aging (Albany NY). 2021 Sep 7;13(17):21470-21482. doi: 10.18632/aging.203487. Epub 2021 Sep 7. PMID: 34491906; PMCID: PMC8457588.

19．Bao Q, Liu Y, Zhang X, Li Y, Wang Z, Ye F, He X, Xia M, Chen Z, Yao J, Zhong W, Wu K, Wang Z, Sun M, Chen J, Hong X, Zhao L, Yin Z, Liang F. Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial. Front Med (Lausanne). 2023 Jun 21;10:1198579. doi: 10.3389/fmed.2023.1198579. PMID: 37415772; PMCID: PMC10321407.

20．Ye XX, Jiang QY, Wu MJ, Ye QH, Zheng H. Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation. Acta Pharmacol Sin. 2024 Dec;45(12):2513-2526. doi: 10.1038/s41401-024-01340-6. Epub 2024 Jul 11. PMID: 38992120; PMCID: PMC11579283.

21．Catumbela CSG, Giridharan VV, Barichello T, Morales R. Clinical evidence of human pathogens implicated in Alzheimer's disease pathology and the therapeutic efficacy of antimicrobials: an overview. Transl Neurodegener. 2023 Jul 26;12(1):37. doi: 10.1186/s40035-023-00369-7. PMID: 37496074; PMCID: PMC10369764.

22．Cox LM, Schafer MJ, Sohn J, Vincentini J, Weiner HL, Ginsberg SD, Blaser MJ. Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice. Sci Rep. 2019 Nov 29;9(1):17904. doi: 10.1038/s41598-019-54187-x. PMID: 31784610; PMCID: PMC6884494.

23．Zhan Y, Chen Z, Zheng S, Dai L, Zhang W, Dai Y, Gao F, Shen Y, Zhang W. Elevated BACE1 and IFNγ+ T Cells in Patients with Cognitive Impairment and the 5xFAD Mouse Model. ACS Chem Neurosci. 2025 Feb 5;16(3):384-392. doi: 10.1021/acschemneuro.4c00565. Epub 2025 Jan 14. PMID: 39810314; PMCID: PMC11804866.

24．Zhang L, Yu F, Xia J. Trimethylamine N-oxide: role in cell senescence and age-related diseases. Eur J Nutr. 2023 Mar;62(2):525-541. doi: 10.1007/s00394-022-03011-w. Epub 2022 Oct 11. PMID: 36219234.

25．Wang T, Kuang W, Chen W, Xu W, Zhang L, Li Y, Li H, Peng Y, Chen Y, Wang B, Xiao J, Li H, Yan C, Du Y, Tang M, He Z, Chen H, Li W, Lin H, Shi S, Bi J, Zhou H, Cheng Y, Gao X, Guan Y, Huang Q, Chen K, Xin X, Ding J, Geng M, Xiao S. A phase II randomized trial of sodium oligomannate in Alzheimer's dementia. Alzheimers Res Ther. 2020 Sep 14;12(1):110. doi: 10.1186/s13195-020-00678-3. PMID: 32928279; PMCID: PMC7489025.

26．Ajayi A, Jolaiya T, Smith S. Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications. J Clin Med. 2020 Aug 7;9(8):2565. doi: 10.3390/jcm9082565. PMID: 32784731; PMCID: PMC7464388.

27．Conn KA, Borsom EM, Cope EK. Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer's disease. Gut Microbes. 2024 Jan-Dec;16(1):2371950. doi: 10.1080/19490976.2024.2371950. Epub 2024 Jul 15. PMID: 39008552; PMCID: PMC11253888.

28．Chen YY, Wang MC, Wang YN, Hu HH, Liu QQ, Liu HJ, Zhao YY. Redox signaling and Alzheimer's disease: from pathomechanism insights to biomarker discovery and therapy strategy. Biomark Res. 2020 Sep 11;8:42. doi: 10.1186/s40364-020-00218-z. PMID: 32944245; PMCID: PMC7488504.

29．Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17;19(1):18. doi: 10.1186/s13024-023-00700-w. Erratum in: Mol Neurodegener. 2024 Oct 10;19(1):70. doi: 10.1186/s13024-024-00764-2. PMID: 38365827; PMCID: PMC10874048.

30．Zhao T, Huang H, Li J, Shen J, Zhou C, Xiao R, Ma W. Association between erythrocyte membrane fatty acids and gut bacteria in obesity-related cognitive dysfunction. AMB Express. 2023 Dec 20;13(1):148. doi: 10.1186/s13568-023-01655-3. PMID: 38123761; PMCID: PMC10733235.

31．Cox LM, Calcagno N, Gauthier C, Madore C, Butovsky O, Weiner HL. The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis. Microbiome. 2022 Mar 11;10(1):47. doi: 10.1186/s40168-022-01232-z. PMID: 35272713; PMCID: PMC8915543.

32．Zhu G, Guo M, Zhao J, Zhang H, Wang G, Chen W. Integrative Metabolomic Characterization Reveals the Mediating Effect of Bifidobacterium breve on Amino Acid Metabolism in a Mouse Model of Alzheimer's Disease. Nutrients. 2022 Feb 9;14(4):735. doi: 10.3390/nu14040735. PMID: 35215385; PMCID: PMC8878368.

33．Cui X, Deng S, Li G, Zhang Y, Wang L, Wu C, Deng Y. Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase. Front Chem. 2022 Dec 21;10:1063284. doi: 10.3389/fchem.2022.1063284. PMID: 36618870;PMCID: PMC9811682.

34．Chen S, Liu H, Wang S, Jiang H, Gao L, Wang L, Teng L, Wang C, Wang D. The Neuroprotection of Verbascoside in Alzheimer's Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-κB-p65 Signaling. Nutrients. 2022 Mar 29;14(7):1417. doi: 10.3390/nu14071417. PMID: 35406030; PMCID: PMC9003273.

35．Zhang T, Gao G, Sakandar HA, Kwok LY, Sun Z. Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target. Front Nutr. 2022 Feb 15;9:814269. doi: 10.3389/fnut.2022.814269. PMID: 35242797; PMCID: PMC8885515.

36．Liu X, Qiu X, Yang Y, Wang J, Wang Q, Liu J, Yang F, Liu Z, Qi R. Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice. iScience. 2023 Feb 13;26(3):106190. doi: 10.1016/j.isci.2023.106190. PMID: 36895644; PMCID: PMC9988658.

37．Yin C, Sun J, Wang H, Yu W, Han F. Identification and Characterization of a New Cold-Adapted and Alkaline Alginate Lyase TsAly7A from Thalassomonas sp. LD5 Produces Alginate Oligosaccharides with High Degree of Polymerization.Mar Drugs. 2022 Dec 22;21(1):6. doi: 10.3390/md21010006. PMID: 36662179; PMCID:PMC9864975.

38．Huang LK, Chao SP, Hu CJ. Clinical trials of new drugs for Alzheimer disease. J Biomed Sci. 2020 Jan 6;27(1):18. doi: 10.1186/s12929-019-0609-7. PMID: 31906949; PMCID: PMC6943903.

39．Pu G, Hou L, Du T, Wang B, Liu H, Li K, Niu P, Zhou W, Huang R, Li P. Effects of short-term feeding with high fiber diets on growth, utilization of dietary fiber, and microbiota in pigs. Front Microbiol. 2022 Jul 27;13:963917. doi: 10.3389/fmicb.2022.963917. PMID: 35966661; PMCID: PMC9363921.

40．Mitrea L, Nemeş SA, Szabo K, Teleky BE, Vodnar DC. Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders. Front Med (Lausanne). 2022 Mar 31;9:813204. doi: 10.3389/fmed.2022.813204. PMID: 35433746; PMCID: PMC9009523.

41．Ding R, Xiao Z, Jiang Y, Yang Y, Ji Y, Bao X, Xing K, Zhou X, Zhu S. Calcitriol ameliorates damage in high-salt diet-induced hypertension: Evidence of communication with the gut-kidney axis. Exp Biol Med (Maywood). 2022 Apr;247(8):624-640. doi: 10.1177/15353702211062507. Epub 2021 Dec 11. PMID: 34894804; PMCID: PMC9039489.

42．Li C, Liu K, Zhu J, Zhu F. The effects of high plasma levels of Aβ_1-42 on mononuclear macrophage in mouse models of Alzheimer's disease. Immun Ageing. 2023 Jul 31;20(1):39. doi: 10.1186/s12979-023-00366-4. PMID: 37525137; PMCID: PMC10388532.

43．Bloomingdale P, Karelina T, Ramakrishnan V, Bakshi S, Véronneau-Veilleux F, Moye M, Sekiguchi K, Meno-Tetang G, Mohan A, Maithreye R, Thomas VA, Gibbons F, Cabal A, Bouteiller JM, Geerts H. Hallmarks of neurodegenerative disease: A systems pharmacology perspective. CPT Pharmacometrics Syst Pharmacol. 2022 Nov;11(11):1399-1429. doi: 10.1002/psp4.12852. Epub 2022 Aug 17. PMID: 35894182;PMCID: PMC9662204.

44．Hassanzadeh A, Yegdaneh A, Rabbani M. Effects of hydroalcoholic, methanolic, and hexane extracts of brown algae Sargassum angustifolium on scopolamine-induced memory impairment and learning deficit in rodents. Res Pharm Sci. 2023 Mar 10;18(3):292-302. doi: 10.4103/1735-5362.371585. PMID: 37593166; PMCID: PMC10427794.

45．He H, Yang M, Li W, Lu Z, Wang Y, Jin M. Fecal microbial and metabolic characteristics of swine from birth to market. Front Microbiol. 2023 Sep 18;14:1191392. doi: 10.3389/fmicb.2023.1191392. PMID: 37789849; PMCID: PMC10543884.

46．Dodiya HB, Frith M, Sidebottom A, Cao Y, Koval J, Chang E, Sisodia SS. Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice. Sci Rep. 2020 May 18;10(1):8183. doi: 10.1038/s41598-020-64797-5. PMID: 32424118; PMCID: PMC7235236.

47．Vecchio I, Sorrentino L, Paoletti A, Marra R, Arbitrio M. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. J Cent Nerv Syst Dis. 2021 Jul 7;13:11795735211029113. doi: 10.1177/11795735211029113. PMID: 34285627; PMCID: PMC8267037.

48．Zheng J, Ni C, Zhang Y, Huang J, Hukportie DN, Liang B, Tang S. Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study. BMC Med. 2023 Mar 29;21(1):114. doi: 10.1186/s12916-023-02816-8. Erratum in: BMC Med. 2023 May 8;21(1):175. doi: 10.1186/s12916-023-02892-w. PMID: 36978077; PMCID: PMC10052856.

49．Huo JY, Jiang WY, Yin T, Xu H, Lyu YT, Chen YY, Chen M, Geng J, Jiang ZX, Shan QJ. Intestinal Barrier Dysfunction Exacerbates Neuroinflammation via the TLR4 Pathway in Mice With Heart Failure. Front Physiol. 2021 Aug 6;12:712338. doi: 10.3389/fphys.2021.712338. PMID: 34421655; PMCID: PMC8378453.

50．Li L, Jiang J, Yao Z, Zhu B. Recent advances in the production, properties and applications of alginate oligosaccharides - a mini review. World J Microbiol Biotechnol. 2023 May 24;39(8):207. doi: 10.1007/s11274-023-03658-5. PMID: 37221433.

51．Di Meco A, Vassar R. Early detection and personalized medicine: Future strategies against Alzheimer's disease. Prog Mol Biol Transl Sci. 2021;177:157-173. doi: 10.1016/bs.pmbts.2020.10.002. Epub 2020 Dec 3. PMID: 33453940; PMCID: PMC8641915.

52．Zhao YF, Wei DN, Tang Y. Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences. Curr Neuropharmacol. 2021;19(8):1354-1366. doi: 10.2174/1570159X19666210215123239. PMID: 33588733;PMCID: PMC8719287.

53．Basak JM, Ferreiro A, Cohen LS, Sheehan PW, Nadarajah CJ, Kanan MF, Sukhum KV, Dantas G, Musiek ES. Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2021 May;152:105292. doi: 10.1016/j.nbd.2021.105292. Epub 2021 Feb 5. PMID: 33556539; PMCID: PMC8057119.

54．Ngah WZW, Ahmad HF, Ankasha SJ, Makpol S, Tooyama I. Dietary Strategies to Mitigate Alzheimer's Disease: Insights into Antioxidant Vitamin Intake and Supplementation with Microbiota-Gut-Brain Axis Cross-Talk. Antioxidants (Basel). 2024 Dec 10;13(12):1504. doi: 10.3390/antiox13121504. PMID: 39765832; PMCID: PMC11673287.

55．Li K, Gao Y, Liu M, Chen Y. Advances in Alzheimer's Disease Biomarkers. Curr Alzheimer Res. 2024;21(11):791-803. doi: 10.2174/0115672050366767241223050957.PMID: 39757626.

56．Shukla PK, Delotterie DF, Xiao J, Pierre JF, Rao R, McDonald MP, Khan MM. Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer's Disease. Cells. 2021 Apr 1;10(4):779. doi: 10.3390/cells10040779. PMID: 33916001; PMCID: PMC8067249.

57．Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K. Alzheimer's disease drug development pipeline: 2020. Alzheimers Dement (N Y). 2020 Jul 16;6(1):e12050. doi: 10.1002/trc2.12050. PMID: 32695874; PMCID: PMC7364858.

58．Haque R, Das II, Sawant PB, Chadha NK, Sahoo L, Kumar R, Sundaray JK. Tenets in Microbial Endocrinology: A New Vista in Teleost Reproduction. Front Physiol. 2022 Aug 12;13:871045. doi: 10.3389/fphys.2022.871045. PMID: 36035477; PMCID:PMC9411670.

59．Mao M, Zhou Y, Jiao Y, Yin S, Cheung C, Yu W, Gao P, Yang L. Bibliometric and visual analysis of research on the links between the gut microbiota and pain from 2002 to 2021. Front Med (Lausanne). 2022 Nov 15;9:975376. doi: 10.3389/fmed.2022.975376. PMID: 36457577; PMCID: PMC9705792.

60．Gan L, Zheng J, Xu WH, Lin J, Liu J, Zhang Y, Wu Z, Lv Z, Jia Y, Guo Q, Chen S, Liu C, Defoirdt T, Qin Q, Liu Y. Deciphering the virulent Vibrio harveyi causing spoilage in muscle of aquatic crustacean Litopenaeus vannamei. Sci Rep. 2022 Sep 29;12(1):16296. doi: 10.1038/s41598-022-20565-1. Erratum in: Sci Rep. 2024 Sep 10;14(1):21131. doi: 10.1038/s41598-024-71652-4. PMID: 36175476; PMCID:PMC9522882.

61．Gonçalves PB, Sodero ACR, Cordeiro Y. Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases. Biomolecules. 2021 May 20;11(5):767. doi: 10.3390/biom11050767. PMID:34065606; PMCID: PMC8160836.

62．Gao F, Chen J, Zhou Y, Cheng L, Hu M, Wang X. Recent progress of small- molecule-based theranostic agents in Alzheimer's disease. RSC Med Chem. 2023 Sep 14;14(11):2231-2245. doi: 10.1039/d3md00330b. PMID: 37974955; PMCID: PMC10650505.

63．Missiego-Beltrán J, Beltrán-Velasco AI. The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases-Therapeutic Approaches: A Comprehensive Review. Int J Mol Sci. 2024 Sep 18;25(18):10041. doi: 10.3390/ijms251810041. PMID: 39337526; PMCID: PMC11431950.

64．Qu Y, Wu Y, Cheng W, Wang D, Zeng L, Wang Y, Li T, Zhang L, Yang J, Sun L, Ai J. Amelioration of cognitive impairment using epigallocatechin-3-gallate in ovariectomized mice fed a high-fat diet involves remodeling withPrevotella and Bifidobacteriales. Front Pharmacol. 2023 Jan 4;13:1079313. doi: 10.3389/fphar.2022.1079313. PMID: 36686657; PMCID: PMC9846573.

65．Karuppusamy S, Rajauria G, Fitzpatrick S, Lyons H, McMahon H, Curtin J, Tiwari BK, O'Donnell C. Biological Properties and Health-Promoting Functions of Laminarin: A Comprehensive Review of Preclinical and Clinical Studies. Mar Drugs. 2022 Dec 10;20(12):772. doi: 10.3390/md20120772. PMID: 36547919; PMCID:PMC9780867.

66．Ma F, Sun M, Song Y, Wang A, Jiang S, Qian F, Mu G, Tuo Y.Lactiplantibacillus plantarum-12 Alleviates Inflammation and Colon Cancer Symptoms in AOM/DSS-Treated Mice through Modulating the Intestinal Microbiome and Metabolome. Nutrients. 2022 May 3;14(9):1916. doi: 10.3390/nu14091916. PMID:35565884; PMCID: PMC9100115.

67．Lin C, Zhao S, Zhu Y, Fan Z, Wang J, Zhang B, Chen Y. Microbiota-gut-brain axis and toll-like receptors in Alzheimer's disease. Comput Struct Biotechnol J. 2019 Oct 24;17:1309-1317. doi: 10.1016/j.csbj.2019.09.008. PMID: 31921396; PMCID: PMC6944716.

68．Zhou X, Lu J, Wei K, Wei J, Tian P, Yue M, Wang Y, Hong D, Li F, Wang B, Chen T, Fang X. Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota. Oxid Med Cell Longev. 2021 Dec 13;2021:9424582. doi: 10.1155/2021/9424582. PMID: 34938384; PMCID: PMC8687851.

69．Juarez VM, Montalbine AN, Singh A. Microbiome as an immune regulator in health, disease, and therapeutics. Adv Drug Deliv Rev. 2022 Sep;188:114400. doi: 10.1016/j.addr.2022.114400. Epub 2022 Jun 16. PMID: 35718251; PMCID: PMC10751508.

70．Frölich L, Hausner L. Krankheitsmodifizierende Therapieansätze bei Alzheimer-Krankheit [Disease-modifying treatment approaches for Alzheimer's disease]. Nervenarzt. 2021 Dec;92(12):1239-1248. German. doi: 10.1007/s00115-021-01222-w. Epub 2021 Nov 4. Erratum in: Nervenarzt. 2024 Dec;95(12):1182. doi: 10.1007/s00115-022-01366-3. PMID: 34735586; PMCID: PMC8648638.

71．Parikh IJ, Estus JL, Zajac DJ, Malik M, Maldonado Weng J, Tai LM, Chlipala GE, LaDu MJ, Green SJ, Estus S. Murine Gut Microbiome Association WithAPOE Alleles. Front Immunol. 2020 Feb 14;11:200. doi: 10.3389/fimmu.2020.00200. PMID: 32117315; PMCID: PMC7034241.

72．Xing M, Cao Q, Wang Y, Xiao H, Zhao J, Zhang Q, Ji A, Song S. Advances in Research on the Bioactivity of Alginate Oligosaccharides. Mar Drugs. 2020 Feb 28;18(3):144. doi: 10.3390/md18030144. PMID: 32121067; PMCID: PMC7142810.

73．Zhang L, Yang C, Li Y, Niu S, Liang X, Zhang Z, Luo Q, Luo H. Dynamic Changes in the Levels of Amyloid-β₄₂ Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease. Front Mol Neurosci. 2021 Aug 27;14:723317. doi: 10.3389/fnmol.2021.723317. PMID: 34512259; PMCID: PMC8430227.

74．Su Z, Xiao Q, Shen J, Chen H, Yan S, Huang W. Metabolomics Analysis of Litchi Leaves during Floral Induction Reveals Metabolic Improvement by Stem Girdling. Molecules. 2021 Jul 2;26(13):4048. doi: 10.3390/molecules26134048. PMID: 34279388; PMCID: PMC8271987.

75．Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL. Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice. Alzheimers Dement. 2024 Jul;20(7):4935-4950. doi: 10.1002/alz.13794. Epub 2024 Apr 4. PMID: 38572865; PMCID: PMC11247698.

76．Qin P, Sun Y, Li L. Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review). Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5. PMID: 38577947; PMCID: PMC10999227.

77．Ji S, Wu Y, Zhu R, Guo D, Jiang Y, Huang L, Ma X, Yu L. Novel Phenylethanoid Glycosides Improve Hippocampal Synaptic Plasticity via the Cyclic Adenosine Monophosphate-CREB-Brain-Derived Neurotrophic Growth Factor Pathway in APP/PS1 Transgenic Mice. Gerontology. 2023;69(9):1065-1075. doi: 10.1159/000531194. Epub 2023 Jun 7. PMID: 37285833; PMCID: PMC10568609.

78．Wong-Guerra M, Calfio C, Maccioni RB, Rojo LE. Revisiting the neuroinflammation hypothesis in Alzheimer's disease: a focus on the druggability of current targets. Front Pharmacol. 2023 Jun 9;14:1161850. doi: 10.3389/fphar.2023.1161850. PMID: 37361208; PMCID: PMC10288808.

79．Jiang J, Shi H, Jiang S, Wang A, Zou X, Wang Y, Li W, Zhang Y, Sun M, Ren Q, Xu J. Nutrition in Alzheimer's disease: a review of an underappreciated pathophysiological mechanism. Sci China Life Sci. 2023 Oct;66(10):2257-2279. doi: 10.1007/s11427-022-2276-6. Epub 2023 Apr 7. PMID: 37058185.

80．Wu Q, Li Q, Zhang X, Ntim M, Wu X, Li M, Wang L, Zhao J, Li S. Treatment with Bifidobacteria can suppress Aβ accumulation and neuroinflammation in APP/PS1 mice. PeerJ. 2020 Oct 28;8:e10262. doi: 10.7717/peerj.10262. PMID: 33194428; PMCID: PMC7602682.

81．Zhu F, Li C, Chu F, Tian X, Zhu J. Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease. Front Aging Neurosci. 2020 Oct 6;12:544235. doi: 10.3389/fnagi.2020.544235. PMID: 33132894; PMCID: PMC7572848.

82．Wang T, Ju M, Zhang X, Feng W, Wang L, Hao L, Yu H, Xiao R. Dietary mixed-oxysterols and 27-Hydroxycholesterol induce cognitive impairment by regulating gut microbiota and miR-144-3p in vivo. Geroscience. 2025 Mar 26. doi: 10.1007/s11357-025-01628-3. Epub ahead of print. PMID: 40138128.

83．Kulkarni R, Kumari S, Dhapola R, Sharma P, Singh SK, Medhi B, HariKrishnaReddy D. Association Between the Gut Microbiota and Alzheimer's Disease: An Update on Signaling Pathways and Translational Therapeutics. Mol Neurobiol. 2025 Apr;62(4):4499-4519. doi: 10.1007/s12035-024-04545-2. Epub 2024 Oct 26. PMID: 39460901.

84．Dong H, Dong S, Erik Hansen P, Stagos D, Lin X, Liu M. Progress of Bromophenols in Marine Algae from 2011 to 2020: Structure, Bioactivities, and Applications. Mar Drugs. 2020 Aug 4;18(8):411. doi: 10.3390/md18080411. PMID: 32759739; PMCID: PMC7459620.

85．Wu Z, Zhang T, Ma X, Guo S, Zhou Q, Zahoor A, Deng G. Recent advances in anti-inflammatory active components and action mechanisms of natural medicines. Inflammopharmacology. 2023 Dec;31(6):2901-2937. doi: 10.1007/s10787-023-01369-9.Epub 2023 Nov 10. PMID: 37947913.

86．Vuong HE, Coley EJL, Kazantsev M, Cooke ME, Rendon TK, Paramo J, Hsiao EY. Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice. Behav Brain Res. 2021 Jul 23;410:113353. doi: 10.1016/j.bbr.2021.113353. Epub 2021 May 9. PMID: 33979656; PMCID: PMC10337120.

87．Wu PN, Xiong S, Zhong P, Yang WQ, Chen M, Tang TC. Global trends in research on irritable bowel syndrome and the brain-gut axis: Bibliometrics and visualization analysis. Front Pharmacol. 2022 Sep 8;13:956204. doi: 10.3389/fphar.2022.956204. PMID: 36160395; PMCID: PMC9493189.

88．Liu Y, Echeverria V, Xu Y. Editorial: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside. Front Pharmacol. 2020 Sep 23;11:585155. doi: 10.3389/fphar.2020.585155. PMID: 33071796; PMCID: PMC7538617.

89．Martins M, Silva R, M M Pinto M, Sousa E. Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease. Pharmaceuticals (Basel). 2020 Sep 11;13(9):242. doi: 10.3390/ph13090242. PMID: 32933034; PMCID: PMC7558913.

90．Janssens Y, Debunne N, De Spiegeleer A, Wynendaele E, Planas M, Feliu L, Quarta A, Claes C, Van Dam D, De Deyn PP, Ponsaerts P, Blurton-Jones M, De Spiegeleer B. PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Sci Rep. 2021 May 21;11(1):10723. doi: 10.1038/s41598-021-90030-y. PMID: 34021199; PMCID: PMC8140105.

91．Kang JN, Sun ZF, Li XY, Zhang XD, Jin ZX, Zhang C, Zhang Y, Wang HY, Huang NN, Jiang JH, Ning B. Alterations in gut microbiota are related to metabolite profiles in spinal cord injury. Neural Regen Res. 2023 May;18(5):1076-1083. doi: 10.4103/1673-5374.355769. PMID: 36254996; PMCID: PMC9827763.

92．Lana D, Traini C, Bulli I, Sarti G, Magni G, Attorre S, Giovannini MG, Vannucchi MG. Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer's disease in a APP/PS1 transgenic mouse model. Front Pharmacol. 2024 Aug 6;15:1451114. doi: 10.3389/fphar.2024.1451114. PMID: 39166107; PMCID: PMC11333230.

93．Yang M, Sun D, Wang Y, Yan M, Zheng J, Ren J. Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions. Front Cardiovasc Med. 2022 Feb 7;8:831734. doi: 10.3389/fcvm.2021.831734. PMID: 35198608; PMCID: PMC8858826.

94．Beitnere U, Vilanova-Cuevas B, Christian SG, Taylor C, Berg EL, Copping NA, Dindot SV, Silverman JL, Gareau MG, Segal DJ. Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome. mSystems. 2023 Feb 23;8(1):e0060822. doi: 10.1128/msystems.00608-22. Epub 2023 Jan 4. PMID:36598241; PMCID: PMC9948700.

95．He X, Yang X, Yan X, Huang M, Xiang Z, Lou Y. Individualized Dosage of Tacrolimus for Renal Transplantation Patients Based on Pharmacometabonomics. Molecules. 2022 May 30;27(11):3517. doi: 10.3390/molecules27113517. PMID: 35684454; PMCID: PMC9182099.

96．Panchal SK, John OD, Mathai ML, Brown L. Anthocyanins in Chronic Diseases: The Power of Purple. Nutrients. 2022 May 23;14(10):2161. doi: 10.3390/nu14102161. PMID: 35631301; PMCID: PMC9142943.

97．Dou M, Chu Y, Zhou X, Wang M, Li X, Ma R, Fan Z, Zhao X, Wang W, Li S, Lv Y,Zhu L. Matrine Mediated Immune Protection in MS by Regulating Gut Microbiota andProduction of SCFAs. Mol Neurobiol. 2024 Jan;61(1):74-90. doi: 10.1007/s12035-023-03568-5. Epub 2023 Aug 15. PMID: 37581848.

98．Zhong SR, Kuang Q, Zhang F, Chen B, Zhong ZG. Functional roles of the microbiota-gut-brain axis in Alzheimer's disease: Implications of gut microbiota-targeted therapy. Transl Neurosci. 2021 Dec 28;12(1):581-600. doi: 10.1515/tnsci-2020-0206. PMID: 35070442; PMCID: PMC8724360.

99．Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020 Jan 31;11:25. doi: 10.3389/fendo.2020.00025. PMID: 32082260; PMCID: PMC7005631.

100．Yu G, Chen Y, Yang N, Zhang H, Zhang X, Geng Y, Zhao J, Chen Z, Dong C, Lin L, Qi J, Zhang X, Jiang X, Gao W, Cai Y, Wang X, Ding J, Xiao J, Zhou K. Apoptotic Bodies Derived from Fibroblast-Like Cells in Subcutaneous Connective Tissue Inhibit Ferroptosis in Ischaemic Flaps via the miR-339-5p/KEAP1/Nrf2 Axis. Adv Sci (Weinh). 2024 Jun;11(24):e2307238. doi: 10.1002/advs.202307238. Epub 2024 Apr 19. PMID: 38639443; PMCID: PMC11200024.

101．Li L, Mayne J, Beltran A, Zhang X, Ning Z, Figeys D. RapidAIM 2.0: a high- throughput assay to study functional response of human gut microbiome to xenobiotics. Microbiome Res Rep. 2024 Apr 3;3(2):26. doi: 10.20517/mrr.2023.57. PMID: 38841404; PMCID: PMC11149095.

102．Komaroff AL, Pellett PE, Jacobson S. Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation. Clin Microbiol Rev. 2020 Nov 11;34(1):e00143-20. doi: 10.1128/CMR.00143-20. PMID: 33177186; PMCID: PMC7667666.

103．Cummings J. New approaches to symptomatic treatments for Alzheimer's disease. Mol Neurodegener. 2021 Jan 13;16(1):2. doi: 10.1186/s13024-021-00424-9. Erratum in: Mol Neurodegener. 2021 Apr 1;16(1):21. doi: 10.1186/s13024-021-00446-3. PMID: 33441154; PMCID: PMC7805095.

104．Zhao Y, Zhan JK, Liu Y. A Perspective on Roles Played by Immunosenescence in the Pathobiology of Alzheimer's Disease. Aging Dis. 2020 Dec 1;11(6):1594-1607. doi: 10.14336/AD.2020.0205. PMID: 33269109; PMCID: PMC7673850.

105．Ling Z, Zhu M, Yan X, Cheng Y, Shao L, Liu X, Jiang R, Wu S. Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease. Front Cell Dev Biol. 2021 Feb 4;8:634069. doi: 10.3389/fcell.2020.634069. PMID: 33614635; PMCID: PMC7889981.

106．Bauer S, Jin W, Zhang F, Linhardt RJ. The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer's Disease. Mar Drugs. 2021 Feb 4;19(2):89. doi: 10.3390/md19020089. PMID: 33557077; PMCID: PMC7913876.

107．Wang X, Xie Z, Yuan J, Jin E, Lian W, Chang S, Sun G, Feng Z, Xu H, Du C, Yang X, Xia A, Qiu J, Zhang Q, Lin F, Liu J, Li L, Du X, Xiao Z, Yi Z, Luo Z, Ge C, Li R, Zheng M, Jiang Y, Wang T, Zhang J, Guo Q, Geng M. Sodium oligomannate disrupts the adherence of Rib^high bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice. Cell Discov. 2024 Nov 19;10(1):115. doi: 10.1038/s41421-024-00725-5. PMID: 39557828; PMCID: PMC11573985.

108．Sighencea MG, Popescu RȘ, Trifu SC. From Fundamentals to Innovation in Alzheimer's Disease: Molecular Findings and Revolutionary Therapies. Int J Mol Sci. 2024 Nov 16;25(22):12311. doi: 10.3390/ijms252212311. PMID: 39596378; PMCID: PMC11594972.

109．Chen R, Chai X, Zhang Y, Zhou T, Xia Y, Jiang X, Lv B, Zhang J, Zhou L, Tian X, Wang R, Mao L, Zhao F, Zhang H, Hu J, Qiu J, Zou Z, Chen C. Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure. Gut Microbes. 2025 Dec;17(1):2438471. doi: 10.1080/19490976.2024.2438471. Epub 2025Jan 24. PMID: 39852343; PMCID: PMC11776478.

110．Sönmez G, Yazarkan Y, Aki ÖE, Bodur E. Unraveling the Enigma: Exploring the Periphery's Influence in Alzheimer's Pathophysiology-Cause or Consequence? Eurasian J Med. 2025 Apr 4;57(1):1-8. doi: 10.5152/eurasianjmed.2025.24592. PMID: 40377430; PMCID: PMC12036350.

111．Balkhi S, Di Spirito A, Poggi A, Mortara L. Immune Modulation in Alzheimer's Disease: From Pathogenesis to Immunotherapy. Cells. 2025 Feb 12;14(4):264. doi: 10.3390/cells14040264. PMID: 39996737; PMCID: PMC11853524.

112．Ni J, Wu Z. Inflammation Spreading: Negative Spiral Linking Systemic Inflammatory Disorders and Alzheimer's Disease. Front Cell Neurosci. 2021 Feb 25;15:638686. doi: 10.3389/fncel.2021.638686. PMID: 33716675; PMCID: PMC7947253.

113．Gong L, Wang H, Zhu X, Dong Q, Yu Q, Mao B, Meng L, Zhao Y, Liu X. Nomogram to Predict Cognitive Dysfunction After a Minor Ischemic Stroke in Hospitalized- Population. Front Aging Neurosci. 2021 Apr 14;13:637363. doi: 10.3389/fnagi.2021.637363. PMID: 33967738; PMCID: PMC8098660.

114．Svob Strac D, Konjevod M, Sagud M, Nikolac Perkovic M, Nedic Erjavec G, Vuic B, Simic G, Vukic V, Mimica N, Pivac N. Personalizing the Care and Treatment of Alzheimer's Disease: An Overview. Pharmgenomics Pers Med. 2021 May 28;14:631-653. doi: 10.2147/PGPM.S284615. PMID: 34093032; PMCID: PMC8169052.

115．Yang Y, Qiu L. Research Progress on the Pathogenesis, Diagnosis, and Drug Therapy of Alzheimer's Disease. Brain Sci. 2024 Jun 9;14(6):590. doi: 10.3390/brainsci14060590. PMID: 38928590; PMCID: PMC11201671.

116．Hannan MA, Dash R, Haque MN, Mohibbullah M, Sohag AAM, Rahman MA, Uddin MJ, Alam M, Moon IS. Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances. Mar Drugs. 2020 Jul 1;18(7):347. doi: 10.3390/md18070347. PMID: 32630301; PMCID: PMC7401253.

117．He Y, Li B, Sun D, Chen S. Gut Microbiota: Implications in Alzheimer's Disease. J Clin Med. 2020 Jun 29;9(7):2042. doi: 10.3390/jcm9072042. PMID: 32610630; PMCID: PMC7409059.

118．Sonali S, Ray B, Ahmed Tousif H, Rathipriya AG, Sunanda T, Mahalakshmi AM, Rungratanawanich W, Essa MM, Qoronfleh MW, Chidambaram SB, Song BJ. Mechanistic Insights into the Link between Gut Dysbiosis and Major Depression: An Extensive Review. Cells. 2022 Apr 16;11(8):1362. doi: 10.3390/cells11081362. PMID: 35456041; PMCID: PMC9030021.

119．Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. Molecules. 2019 Dec 28;25(1):119. doi: 10.3390/molecules25010119. PMID: 31905602; PMCID:PMC6983133.

120．Wu Q, O'Malley J, Datta S, Gharaibeh RZ, Jobin C, Karagas MR, Coker MO, Hoen AG, Christensen BC, Madan JC, Li Z. MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data. Genes (Basel). 2022 Jun 11;13(6):1049. doi: 10.3390/genes13061049. PMID: 35741811; PMCID: PMC9223163.

121．Chi L, Cheng X, Lin L, Yang T, Sun J, Feng Y, Liang F, Pei Z, Teng W.Porphyromonas gingivalis-Induced Cognitive Impairment Is Associated With Gut Dysbiosis, Neuroinflammation, and Glymphatic Dysfunction. Front Cell Infect Microbiol. 2021 Dec 1;11:755925. doi: 10.3389/fcimb.2021.755925. PMID: 34926316;PMCID: PMC8672439.

122．López-Villodres JA, Escamilla A, Mercado-Sáenz S, Alba-Tercedor C, Rodriguez-Perez LM, Arranz-Salas I, Sanchez-Varo R, Bermúdez D. Microbiome Alterations and Alzheimer's Disease: Modeling Strategies with Transgenic Mice. Biomedicines. 2023 Jun 27;11(7):1846. doi: 10.3390/biomedicines11071846. PMID: 37509487; PMCID: PMC10377071.

123．Ma F, Song Y, Sun M, Wang A, Jiang S, Mu G, Tuo Y. Exopolysaccharide Produced by Lactiplantibacillus plantarum-12 Alleviates Intestinal Inflammation and Colon Cancer Symptoms by Modulating the Gut Microbiome and Metabolites of C57BL/6 Mice Treated by Azoxymethane/Dextran Sulfate Sodium Salt.Foods. 2021 Dec 9;10(12):3060. doi: 10.3390/foods10123060. PMID: 34945611; PMCID: PMC8701795.

124．Kong Y, Chen Z, Feng X, Zuo Y, Zhang J. Gut microbiota and metabolome in sporadic Creutzfeldt-Jakob disease. J Neurol. 2023 Dec;270(12):6021-6032. doi: 10.1007/s00415-023-11961-2. Epub 2023 Aug 29. PMID: 37642736.

125．Shemtov SJ, Emani R, Bielska O, Covarrubias AJ, Verdin E, Andersen JK, Winer DA. The intestinal immune system and gut barrier function in obesity and ageing. FEBS J. 2023 Sep;290(17):4163-4186. doi: 10.1111/febs.16558. Epub 2022 Jul 1. PMID: 35727858; PMCID: PMC9768107.

126．Kang JW, Zivkovic AM. The Potential Utility of Prebiotics to Modulate Alzheimer's Disease: A Review of the Evidence. Microorganisms. 2021 Nov 6;9(11):2310. doi: 10.3390/microorganisms9112310. PMID: 34835436; PMCID: PMC8625457.

127．Yan Y, Gao Y, Fang Q, Zhang N, Kumar G, Yan H, Song L, Li J, Zhang Y, Sun J, Wang J, Zhao L, Skaggs K, Zhang HT, Ma CG. Inhibition of Rho Kinase by Fasudil Ameliorates Cognition Impairment in APP/PS1 Transgenic Mice via Modulation of Gut Microbiota and Metabolites. Front Aging Neurosci. 2021 Oct 14;13:755164. doi: 10.3389/fnagi.2021.755164. PMID: 34721000; PMCID: PMC8551711.

128．Perna A, Montine KS, White LR, Montine TJ, Cholerton BA. Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia. Neurotherapeutics. 2023 Oct;20(6):1641-1652. doi: 10.1007/s13311-023-01441-w. Epub 2023 Sep 21. PMID: 37733209; PMCID: PMC10684852.

129．Huang W, Zhou Y, Tu L, Ba Z, Huang J, Huang N, Luo Y. TDP-43: From Alzheimer's Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy. Front Mol Neurosci. 2020 Feb 28;13:26. doi: 10.3389/fnmol.2020.00026. PMID: 32180703; PMCID: PMC7059763.

130．Xie R, Chen F, Ma Y, Hu W, Zheng Q, Cao J, Wu Y. Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer's disease. Front Pharmacol. 2023 Oct 19;14:1249632. doi: 10.3389/fphar.2023.1249632. PMID: 37927608; PMCID: PMC10620974.

131．Liufu N, Liu L, Shen S, Jiang Z, Dong Y, Wang Y, Culley D, Crosby G, Cao M, Shen Y, Marcantonio E, Xie Z, Zhang Y. Anesthesia and surgery induce age- dependent changes in behaviors and microbiota. Aging (Albany NY). 2020 Jan 24;12(2):1965-1986. doi: 10.18632/aging.102736. Epub 2020 Jan 24. PMID: 31974315; PMCID: PMC7053599.

132．Liang J, Wang Y, Liu B, Dong X, Cai W, Zhang N, Zhang H. Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies. CNS Neurosci Ther. 2024 Apr;30(4):e14704. doi: 10.1111/cns.14704. PMID: 38584341; PMCID: PMC10999574.

133．Wu Y, Guo S, Wang K, Kang J. The interaction of peptide inhibitors and Aβ protein: Binding mode analysis, inhibition of the formation of Aβ aggregates, and then exert neuroprotective effects. Front Aging Neurosci. 2023 Apr 11;15:1139418. doi: 10.3389/fnagi.2023.1139418. PMID: 37113572; PMCID: PMC10126514.

134．Qian XH, Liu XL, Zhang B, Lin Y, Xu JH, Ding GY, Tang HD. Investigating the causal association between branched-chain amino acids and Alzheimer's disease: A bidirectional Mendelian randomized study. Front Nutr. 2023 Mar 31;10:1103303. doi: 10.3389/fnut.2023.1103303. PMID: 37063328; PMCID: PMC10102518.

135．Ling Z, Zhu M, Liu X, Shao L, Cheng Y, Yan X, Jiang R, Wu S. Fecal Fungal Dysbiosis in Chinese Patients With Alzheimer's Disease. Front Cell Dev Biol. 2021 Jan 28;8:631460. doi: 10.3389/fcell.2020.631460. PMID: 33585471; PMCID: PMC7876328.

136．Cheng X, Wei Y, Qian Z, Han L. Autophagy Balances Neuroinflammation in Alzheimer's Disease. Cell Mol Neurobiol. 2023 May;43(4):1537-1549. doi: 10.1007/s10571-022-01269-6. Epub 2022 Aug 12. PMID: 35960407; PMCID: PMC11412430.

137．Wang SQ, Wang X, Guo L, Chen XX, Huang XJ, Zhang S, Ye WC, Zhang XQ, Shi L, Wang Y, Hu LJ. In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity. ACS Med Chem Lett. 2025 Mar 4;16(3):475-482. doi: 10.1021/acsmedchemlett.4c00635. PMID: 40104800; PMCID: PMC11912280.

138．Zhang Q, Li G, Zhao W, Wang X, He J, Zhou L, Zhang X, An P, Liu Y, Zhang C, Zhang Y, Liu S, Zhao L, Liu R, Li Y, Jiang W, Wang X, Wang Q, Fang B, Zhao Y,Ren Y, Niu X, Li D, Shi S, Hung WL, Wang R, Liu X, Ren F. Efficacy of Bifidobacterium animalis subsp. lactis BL-99 in the treatment of functional dyspepsia: a randomized placebo-controlled clinical trial. Nat Commun. 2024 Jan 3;15(1):227. doi: 10.1038/s41467-023-44292-x. PMID: 38172093; PMCID: PMC10764899.

139．Stoiljkovic M, Horvath TL, Hajós M. Therapy for Alzheimer's disease: Missing targets and functional markers? Ageing Res Rev. 2021 Jul;68:101318. doi: 10.1016/j.arr.2021.101318. Epub 2021 Mar 9. PMID: 33711510; PMCID: PMC8131215.

140．Shivani S, Chattopadhyay A, Chuang EY. Targeting the gut microbiome for non-communicable diseases: present and future. Ann Transl Med. 2021 Mar;9(5):361. doi: 10.21037/atm-21-144. PMID: 33842582; PMCID: PMC8033337.

141．Huo JY, Jiang WY, Lyu YT, Zhu L, Liu HH, Chen YY, Chen M, Geng J, Jiang ZX,Shan QJ. Renal Denervation Attenuates Neuroinflammation in the Brain by Regulating Gut-Brain Axis in Rats With Myocardial Infarction. Front Cardiovasc Med. 2021 Apr 26;8:650140. doi: 10.3389/fcvm.2021.650140. PMID: 33981735; PMCID:PMC8109795.

142．Cao C, Fu G, Xu R, Li N. Coupling of Alzheimer's Disease Genetic Risk Factors with Viral Susceptibility and Inflammation. Aging Dis. 2024 Oct 1;15(5):2028-2050. doi: 10.14336/AD.2023.1017. PMID: 37962454; PMCID: PMC11346407.

143．Wang YL, Zhang Y, Xu J. Sodium oligomannate combined with rivastigmine may improve cerebral blood flow and cognitive impairment following CAR-T cell therapy: A case report. Front Oncol. 2022 Aug 18;12:902301. doi: 10.3389/fonc.2022.902301. PMID: 36059691; PMCID: PMC9433646.

144．Lu Y, Xu K, Lin D, Wang S, Fu R, Deng X, Croppi G, Zhang J. Multi-omics analysis reveals neuroinflammation, activated glial signaling, and dysregulated synaptic signaling and metabolism in the hippocampus of aged mice. Front Aging Neurosci. 2022 Nov 3;14:964429. doi: 10.3389/fnagi.2022.964429. PMID: 36408109; PMCID: PMC9669972.

145．Ceppa FA, Izzo L, Sardelli L, Raimondi I, Tunesi M, Albani D, Giordano C. Human Gut-Microbiota Interaction in Neurodegenerative Disorders and Current Engineered Tools for Its Modeling. Front Cell Infect Microbiol. 2020 Jul 7;10:297. doi: 10.3389/fcimb.2020.00297. PMID: 32733812; PMCID: PMC7358350.

146．Jiang Y, Guo Z, Liu X, Wang Y, Li J, Wang B. Effects of Aricept on intestinal flora diversity in patients with mild Alzheimer's disease explored through high-throughput sequencing technology. Am J Transl Res. 2021 Apr 15;13(4):2486-2498. PMID: 34017407; PMCID: PMC8129215.

147．Yang X, Zhangyi Z, Yu A, Zhou Q, Xia A, Qiu J, Cai M, Chu X, Li L, Feng Z, Luo Z, Sun G, Zhang J, Geng M, Chen S, Xie Z. GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities. CNS Neurosci Ther. 2024 Jul;30(7):e14847. doi: 10.1111/cns.14847. PMID: 38973196; PMCID: PMC11228355.

148．Al-Ghraiybah NF, Wang J, Alkhalifa AE, Roberts AB, Raj R, Yang E, Kaddoumi A. Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease. Int J Mol Sci. 2022 Sep 12;23(18):10572. doi: 10.3390/ijms231810572. PMID: 36142483; PMCID:PMC9502483.

149．Rui W, Wu Y, Yang Y, Xie W, Qin D, Ming J, Ye Z, Lu L, Zong M, Tang X, Fan L, Li S. Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer's disease. J Neuroinflammation. 2024 Oct 19;21(1):266. doi: 10.1186/s12974-024-03255-9. PMID: 39427168; PMCID: PMC11491014.

150．Wen Y, Li S, Wang Z, Feng H, Yao X, Liu M, Chang J, Ding X, Zhao H, Ma W.Intestinal Microbial Diversity of Free-Range and Captive Yak in Qinghai Province. Microorganisms. 2022 Mar 31;10(4):754. doi: 10.3390/microorganisms10040754. PMID: 35456805; PMCID: PMC9028582.

151．Bou Zerdan M, Hebbo E, Hijazi A, El Gemayel M, Nasr J, Nasr D, Yaghi M, Bouferraa Y, Nagarajan A. The Gut Microbiome and Alzheimer's Disease: A Growing Relationship. Curr Alzheimer Res. 2022;19(12):808-818. doi: 10.2174/1567205020666221227090125. PMID: 36578263.

152．Hammond TC, Lin AL. Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer's Disease than Amyloid or Tau. J Cell Immunol. 2022;4(1):15-18. PMID: 35373192; PMCID: PMC8975178.

153．Yan C, Qu H, Li X, Feng B. Holothurian Wall Hydrolysate Ameliorates Cyclophosphamide-Induced Immunocompromised Mice via Regulating Immune Response and Improving Gut Microbiota. Int J Mol Sci. 2023 Aug 9;24(16):12583. doi:10.3390/ijms241612583. PMID: 37628768; PMCID: PMC10454611.

154．Pereira TMC, Côco LZ, Ton AMM, Meyrelles SS, Campos-Toimil M, Campagnaro BP, Vasquez EC. The Emerging Scenario of the Gut-Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases. Antioxidants(Basel). 2021 Nov 20;10(11):1845. doi: 10.3390/antiox10111845. PMID: 34829716;PMCID: PMC8614795.

155．Song S, Wei Q, Wang K, Yang Q, Wang Y, Ji A, Chen G. Fluorescent Labeling of Polymannuronic Acid and Its Distribution in Mice by Tail Vein Injection. Mar Drugs. 2022 Apr 25;20(5):289. doi: 10.3390/md20050289. PMID: 35621940; PMCID:PMC9145981.

156．Martins B, Vieira M, Delerue-Matos C, Grosso C, Soares C. Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae- Derived Compounds with Neuroprotective Activity: A Comprehensive Review. Mar Drugs. 2022 May 28;20(6):362. doi: 10.3390/md20060362. PMID: 35736165; PMCID:PMC9227170.

157．Dai L, Shen Y. Insights into T-cell dysfunction in Alzheimer's disease. Aging Cell. 2021 Dec;20(12):e13511. doi: 10.1111/acel.13511. Epub 2021 Nov 1. PMID: 34725916; PMCID: PMC8672785.

158．Liang J, Liu B, Dong X, Wang Y, Cai W, Zhang N, Zhang H. Decoding the role of gut microbiota in Alzheimer's pathogenesis and envisioning future therapeutic avenues. Front Neurosci. 2023 Sep 18;17:1242254. doi: 10.3389/fnins.2023.1242254. PMID: 37790586; PMCID: PMC10544353.

159．Pan Z, Wu N, Jin C. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients. Can J Infect Dis Med Microbiol. 2023 Oct 28;2023:3080969. doi: 10.1155/2023/3080969. PMID: 37927531;PMCID: PMC10625490.

160．Wang Y, Zhang X, Song Q, Hou Y, Liu J, Sun Y, Wang P. Characterization of the chromatin accessibility in an Alzheimer's disease (AD) mouse model. Alzheimers Res Ther. 2020 Mar 23;12(1):29. doi: 10.1186/s13195-020-00598-2. PMID: 32293531; PMCID: PMC7092509.

161．Den H, Dong X, Chen M, Zou Z. Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer's disease or mild cognitive impairment - a meta-analysis of randomized controlled trials. Aging (Albany NY). 2020 Feb 15;12(4):4010-4039. doi: 10.18632/aging.102810. Epub 2020 Feb 15. PMID: 32062613; PMCID: PMC7066922.

162．Scassellati C, Galoforo AC, Esposito C, Ciani M, Ricevuti G, Bonvicini C. Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer's Disease and Its Neuropsychiatric Symptoms. Aging Dis. 2021 Aug 1;12(5):1337-1357. doi: 10.14336/AD.2021.0122. PMID: 34341712; PMCID: PMC8279527.

163．Yu TW, Lane HY, Lin CH. Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review. Int J Mol Sci. 2021 Jul 30;22(15):8208. doi: 10.3390/ijms22158208. PMID: 34360973; PMCID: PMC8348485.

164．Zhu Y, Mei Y, Baby N, Teo HY, Binte Hanafi Z, Mohd Salleh SN, Sajikumar S, Liu H. Tumor-mediated microbiota alteration impairs synaptic tagging/capture in the hippocampal CA1 area via IL-1β production. Commun Biol. 2023 Jul 3;6(1):685.doi: 10.1038/s42003-023-05036-1. PMID: 37400621; PMCID: PMC10318068.

165．Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther. 2023 Jul 12;8(1):267. doi: 10.1038/s41392-023-01486-5. PMID: 37433768; PMCID: PMC10336149.

166．Solanki R, Karande A, Ranganathan P. Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration. Front Neurol. 2023 May 15;14:1149618. doi: 10.3389/fneur.2023.1149618. PMID: 37255721; PMCID: PMC10225576.

167．Ettcheto M, Busquets O, Cano A, Sánchez-Lopez E, Manzine PR, Espinosa- Jimenez T, Verdaguer E, Sureda FX, Olloquequi J, Castro-Torres RD, Auladell C, Folch J, Casadesús G, Camins A. Pharmacological Strategies to Improve Dendritic Spines in Alzheimer's Disease. J Alzheimers Dis. 2021;82(s1):S91-S107. doi: 10.3233/JAD-201106. PMID: 33325386; PMCID: PMC9853464.

168．Du D, Tang W, Zhou C, Sun X, Wei Z, Zhong J, Huang Z. Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury. Oxid Med Cell Longev. 2021 Feb 10;2021:5816837. doi: 10.1155/2021/5816837. PMID: 33628361; PMCID: PMC7894052.

169．Jin Q, Wang S, Yao Y, Jiang Q, Li K. The gut-eye axis: from brain neurodegenerative diseases to age-related macular degeneration. Neural Regen Res. 2025 Oct 1;20(10):2741-2757. doi: 10.4103/NRR.NRR-D-24-00531. Epub 2024 Oct 22. PMID: 39435619; PMCID: PMC11826455.

170．Lei S, Wang M, Pan J, Wang D, Ge P, Zhang D. Association between peripheral blood serum phenylalanine to tyrosine ratio and the risk of moyamoya disease: a case-control study. Front Neurol. 2025 Apr 3;16:1554697. doi: 10.3389/fneur.2025.1554697. PMID: 40248014; PMCID: PMC12003120.

171．Junyi L, Yueyang W, Bin L, Xiaohong D, Wenhui C, Ning Z, Hong Z. Gut Microbiota Mediates Neuroinflammation in Alzheimer's Disease: Unraveling Key Factors and Mechanistic Insights. Mol Neurobiol. 2025 Mar;62(3):3746-3763. doi: 10.1007/s12035-024-04513-w. Epub 2024 Sep 25. PMID: 39317889.

172．Xu X, Jin H, Li X, Yan C, Zhang Q, Yu X, Liu Z, Liu S, Zhu F. Fecal Microbiota Transplantation Regulates Blood Pressure by Altering Gut Microbiota Composition and Intestinal Mucosal Barrier Function in Spontaneously Hypertensive Rats. Probiotics Antimicrob Proteins. 2024 Aug 22. doi: 10.1007/s12602-024-10344-x. Epub ahead of print. PMID: 39172216.

173．Wang H, Ren S, Lv H, Cao L. Gut microbiota from mice with cerebral ischemia-reperfusion injury affects the brain in healthy mice. Aging (Albany NY). 2021 Mar 26;13(7):10058-10074. doi: 10.18632/aging.202763. Epub 2021 Mar 26. PMID: 33795522; PMCID: PMC8064205.

174．Fulop T, Tripathi S, Rodrigues S, Desroches M, Bunt T, Eiser A, Bernier F, Beauregard PB, Barron AE, Khalil A, Plotka A, Hirokawa K, Larbi A, Bocti C, Laurent B, Frost EH, Witkowski JM. Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer's Disease. Neuropsychiatr Dis Treat. 2021 May 4;17:1311-1339. doi: 10.2147/NDT.S264910. PMID: 33976546; PMCID: PMC8106529.

175．Hu H, Meng J, Zheng H, Cai H, Wang M, Luo Z, E Y, Li C, Wu Q, Yan Z, Lei Y. Relief effect of biochar on continuous cropping of tobacco through the reduction of p-hydroxybenzoic acid in soil. Heliyon. 2024 Jun 15;10(12):e33011. doi: 10.1016/j.heliyon.2024.e33011. PMID: 38994090; PMCID: PMC11238006.

176．Navolokin N, Adushkina V, Zlatogorskaya D, Telnova V, Evsiukova A, Vodovozova E, Eroshova A, Dosadina E, Diduk S, Semyachkina-Glushkovskaya O. Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer's Disease. Pharmaceuticals (Basel). 2024 Jun 16;17(6):788. doi: 10.3390/ph17060788. PMID: 38931455; PMCID: PMC11206883.

177．Sun D, Xiang H, Yan J, He L. Intestinal microbiota: A promising therapeutic target for hypertension. Front Cardiovasc Med. 2022 Nov 15;9:970036. doi: 10.3389/fcvm.2022.970036. PMID: 36457803; PMCID: PMC9705378.

178．Fu Y, Gu Z, Cao H, Zuo C, Huang Y, Song Y, Jiang Y, Wang F. The role of the gut microbiota in neurodegenerative diseases targeting metabolism. Front Neurosci. 2024 Sep 26;18:1432659. doi: 10.3389/fnins.2024.1432659. PMID: 39391755; PMCID: PMC11464490.

179．Wu S, Liu X, Jiang R, Yan X, Ling Z. Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer's Disease. Front Aging Neurosci. 2021 May 28;13:650047. doi: 10.3389/fnagi.2021.650047. PMID: 34122039; PMCID: PMC8193064.

180．Siddik MAB, Mullins CA, Kramer A, Shah H, Gannaban RB, Zabet-Moghaddam M,Huebinger RM, Hegde VK, MohanKumar SMJ, MohanKumar PS, Shin AC. Branched-Chain Amino Acids Are Linked with Alzheimer's Disease-Related Pathology and Cognitive Deficits. Cells. 2022 Nov 7;11(21):3523. doi: 10.3390/cells11213523. PMID:36359919; PMCID: PMC9658564.

181．Meng Q, Tang Z, Yang F, Shi J, Liu T, Cheng S. Functional analysis of microorganisms and metabolites in the cecum of different sheep populations and their effects on production traits. Front Microbiol. 2024 Sep 16;15:1437250. doi: 10.3389/fmicb.2024.1437250. PMID: 39351299; PMCID: PMC11439670.

182．Ruan YN, Nong C, Jintrawet A, Fan H, Fu L, Zheng SJ, Li S, Wang ZY. A smooth vetch (Vicia villosa var.) strain endogenous to the broad-spectrum antagonist Bacillus siamensis JSZ06 alleviates banana wilt disease. Front Plant Sci. 2024 Jun 4;15:1410197. doi: 10.3389/fpls.2024.1410197. PMID: 38978518; PMCID: PMC11229777.

183．Zhao Q, Yu J, Zhou H, Wang X, Zhang C, Hu J, Hu Y, Zheng H, Zeng F, Yue C, Gu L, Wang Z, Zhao F, Zhou P, Zhang H, Huang N, Wu W, Zhou Y, Li J. Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism. Signal Transduct Target Ther. 2023 Jan 30;8(1):40. doi: 10.1038/s41392-022-01219-0. PMID: 36710269; PMCID: PMC9884668.

184．Liu W, He K, Wu D, Zhou L, Li G, Lin Z, Yang X, Liu J, Pui Man Hoi M. Natural Dietary Compound Xanthohumol Regulates the Gut Microbiota and Its Metabolic Profile in a Mouse Model of Alzheimer's Disease. Molecules. 2022 Feb 14;27(4):1281. doi: 10.3390/molecules27041281. PMID: 35209070; PMCID: PMC8880053.

185．Tarawneh R, Penhos E. The gut microbiome and Alzheimer's disease: Complex and bidirectional interactions. Neurosci Biobehav Rev. 2022 Oct;141:104814. doi: 10.1016/j.neubiorev.2022.104814. Epub 2022 Aug 4. PMID: 35934087; PMCID: PMC9637435.

186．Zhang L, Bai YY, Hong ZS, Xie J, Tian Y. Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review. Nutrients. 2023 Sep 21;15(18):4085. doi: 10.3390/nu15184085. PMID: 37764868; PMCID: PMC10534798.

187．Pu G, Li P, Du T, Niu Q, Fan L, Wang H, Liu H, Li K, Niu P, Wu C, Zhou W, Huang R. Adding Appropriate Fiber in Diet Increases Diversity and Metabolic Capacity of Distal Gut Microbiota Without Altering Fiber Digestibility and Growth Rate of Finishing Pig. Front Microbiol. 2020 Apr 9;11:533. doi: 10.3389/fmicb.2020.00533. PMID: 32328041; PMCID: PMC7160236.

188．Prajapati SK, Shah R, Alford N, Mishra SP, Jain S, Hansen B, Sanberg P, Molina AJA, Yadav H. The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2187-2202. doi: 10.1093/gerona/glad226. PMID: 37738628; PMCID: PMC10692438.

189．Sililas P, Huang L, Thonusin C, Luewan S, Chattipakorn N, Chattipakorn S, Tongsong T. Association between Gut Microbiota and Development of Gestational Diabetes Mellitus. Microorganisms. 2021 Aug 8;9(8):1686. doi: 10.3390/microorganisms9081686. PMID: 34442765; PMCID: PMC8400162.

190．Jalali D, Guevarra JA, Martinez L, Hung L, Vonhoff FJ. Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer's Disease. Int J Mol Sci. 2021 Jun 29;22(13):7022. doi: 10.3390/ijms22137022. PMID: 34209883; PMCID: PMC8269328.

191．Milošević M, Arsić A, Cvetković Z, Vučić V. Memorable Food: Fighting Age- Related Neurodegeneration by Precision Nutrition. Front Nutr. 2021 Aug 5;8:688086. doi: 10.3389/fnut.2021.688086. PMID: 34422879; PMCID: PMC8374314.

192．Li H, Ni J, Qing H. Gut Microbiota: Critical Controller and Intervention Target in Brain Aging and Cognitive Impairment. Front Aging Neurosci. 2021 Jun 25;13:671142. doi: 10.3389/fnagi.2021.671142. PMID: 34248602; PMCID: PMC8267942.

193．Guo X, Gao L, Liu J, Lu W, Wang J, Qu Q. Public acceptability of lumbar puncture in the diagnosis of Alzheimer's disease: a questionnaire-based single center study in China. Am J Transl Res. 2023 Jun 15;15(6):4179-4187. PMID: 37434808; PMCID: PMC10331662.

194．Gu X, Zhou J, Zhou Y, Wang H, Si N, Ren W, Zhao W, Fan X, Gao W, Wei X, Yang J, Bian B, Zhao H. Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the "brain- gut" axis through multiple integrated omics. Alzheimers Res Ther. 2021 Feb 12;13(1):44. doi: 10.1186/s13195-021-00779-7. PMID: 33579351; PMCID: PMC7881564.

195．Tang Z, Wei C, Deng X, Lin Q, Hu Q, Li S, Wang J, Wu Y, Liu D, Fang M, Zhan T. Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis. Front Immunol. 2025 Jan 7;15:1489077. doi: 10.3389/fimmu.2024.1489077. PMID: 39840062; PMCID: PMC11746118.

196．Haghshenas L, Banihashemi S, Malekzadegan Y, Catanzaro R, Moghadam Ahmadi A, Marotta F. Microbiome as an endocrine organ and its relationship with eye diseases: Effective factors and new targeted approaches. World J Gastrointest Pathophysiol. 2024 Sep 22;15(5):96446. doi: 10.4291/wjgp.v15.i5.96446. PMID: 39355345; PMCID: PMC11440246.

197．Zhang S, Lu J, Jin Z, Xu H, Zhang D, Chen J, Wang J. Gut microbiota metabolites: potential therapeutic targets for Alzheimer's disease? Front Pharmacol. 2024 Sep 17;15:1459655. doi: 10.3389/fphar.2024.1459655. PMID: 39355779; PMCID: PMC11442227.

198．Xiaojuan L, Hongmei L, Zhuxin W, Xiaoqin L, Lanbing D, Dan L, Yi Z. Exploration of the pharmacological components and therapeutic mechanisms in treatment of Alzheimer's disease with Polygonati Rhizoma and its processed product using combined analysis of metabolomics, network pharmacology, and gut microbiota. Heliyon. 2024 Jul 30;10(15):e35394. doi: 10.1016/j.heliyon.2024.e35394. PMID: 39170207; PMCID: PMC11336570.

199．Zhang H, Wang Y, Zhao H, Wang W, Han F. The involvement of effector memory CD4⁺ T cells in mediating the impact of genus Oscillibacter gut microbiota on Alzheimer's disease: a Mendelian randomization study. Front Aging Neurosci. 2024 Aug 7;16:1423707. doi: 10.3389/fnagi.2024.1423707. PMID:39170894; PMCID: PMC11335717.

200．Hou J, Wang X, Zhang J, Shen Z, Li X, Yang Y. Chuanxiong Renshen Decoction Inhibits Alzheimer's Disease Neuroinflammation by Regulating PPARγ/NF-κB Pathway. Drug Des Devel Ther. 2024 Jul 24;18:3209-3232. doi: 10.2147/DDDT.S462266. PMID: 39071817; PMCID: PMC11283787.

201．Yue M, Zhang L. Exploring the Mechanistic Interplay between Gut Microbiota and Precocious Puberty: A Narrative Review. Microorganisms. 2024 Feb 4;12(2):323. doi: 10.3390/microorganisms12020323. PMID: 38399733; PMCID: PMC10892899.

202．Liang C, Pereira R, Zhang Y, Rojas OL. Gut Microbiome in Alzheimer's Disease: from Mice to Humans. Curr Neuropharmacol. 2024;22(14):2314-2329. doi: 10.2174/1570159X22666240308090741. PMID: 39403057; PMCID: PMC11451315.

203．Han D, Li Z, Liu T, Yang N, Li Y, He J, Qian M, Kuang Z, Zhang W, Ni C, Guo X. Prebiotics Regulation of Intestinal Microbiota Attenuates Cognitive Dysfunction Induced by Surgery Stimulation in APP/PS1 Mice. Aging Dis. 2020 Oct 1;11(5):1029-1045. doi: 10.14336/AD.2020.0106. PMID: 33014520; PMCID: PMC7505279.

204．Dunham SJB, McNair KA, Adams ED, Avelar-Barragan J, Forner S, Mapstone M, Whiteson KL. Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer's Disease. mBio. 2022 Dec 20;13(6):e0179422. doi: 10.1128/mbio.01794-22. Epub 2022 Dec 5. PMID: 36468884; PMCID: PMC9765021.

205．Chen Y, Zhou J, Wang L. Role and Mechanism of Gut Microbiota in Human Disease. Front Cell Infect Microbiol. 2021 Mar 17;11:625913. doi: 10.3389/fcimb.2021.625913. PMID: 33816335; PMCID: PMC8010197.

206．van Olst L, Roks SJM, Kamermans A, Verhaar BJH, van der Geest AM, Muller M,van der Flier WM, de Vries HE. Contribution of Gut Microbiota to Immunological Changes in Alzheimer's Disease. Front Immunol. 2021 May 31;12:683068. doi: 10.3389/fimmu.2021.683068. PMID: 34135909; PMCID: PMC8200826.

207．Zou C, Cai R, Li Y, Xue Y, Zhang G, Alitongbieke G, Pan Y, Zhang S. β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging- related cognitive impairment. iScience. 2024 Aug 20;27(9):110766. doi: 10.1016/j.isci.2024.110766. PMID: 39280626; PMCID: PMC11401205.

208．Cheng X, Song C, Du Y, Gaur U, Yang M. Pharmacological Treatment of Alzheimer's Disease: Insights from Drosophila melanogaster. Int J Mol Sci. 2020 Jun 29;21(13):4621. doi: 10.3390/ijms21134621. PMID: 32610577; PMCID:PMC7370071.

209．Zhan C, Chen L, Guo D, Sun J, Duan Y, Zhang P, Li P, Ma L, Xu M, Wang Y, Bao H, Gao G, Liu L, Zhang K. An Intestinal Symbiotic Bacterial Strain ofOscheius chongmingensis Modulates Host Viability at Both Global and Post- Transcriptional Levels. Int J Mol Sci. 2022 Nov 24;23(23):14692. doi: 10.3390/ijms232314692. PMID: 36499019; PMCID: PMC9739912.

210．Li F, Feng Y, Liu H, Kong D, Hsueh CY, Shi X, Wu Q, Li W, Wang J, Zhang Y, Dai C. Gut Microbiome and Metabolome Changes in Mice With Acute Vestibular Deficit. Front Cell Infect Microbiol. 2022 Apr 4;12:821780. doi: 10.3389/fcimb.2022.821780. PMID: 35444956; PMCID: PMC9013912.

211．Zhang N, Yan C, Yin C, Hu X, Guan P, Cheng Y. Structural Remodeling Mechanism of the Toxic Amyloid Fibrillary Mediated by Epigallocatechin-3-gallate. ACS Omega. 2022 Dec 13;7(51):48047-48058. doi: 10.1021/acsomega.2c05995. PMID: 36591187; PMCID: PMC9798747.

212．Austad SN, Ballinger S, Buford TW, Carter CS, Smith DL Jr, Darley-Usmar V, Zhang J. Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease. Acta Pharm Sin B. 2022 Feb;12(2):511-531. doi: 10.1016/j.apsb.2021.06.014. Epub 2021 Jun 30. PMID: 35256932; PMCID: PMC8897048.

213．Chen Y, Yu Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. J Neuroinflammation. 2023 Jul 14;20(1):165. doi: 10.1186/s12974-023-02853-3. PMID: 37452321; PMCID: PMC10349496.

214．Fang X, Zhou X, Miao Y, Han Y, Wei J, Chen T. Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease. AMB Express. 2020 Apr 24;10(1):80. doi: 10.1186/s13568-020-01014-6. PMID: 32333225; PMCID: PMC7182653.

215．Louros N, Schymkowitz J, Rousseau F. Mechanisms and pathology of protein misfolding and aggregation. Nat Rev Mol Cell Biol. 2023 Dec;24(12):912-933. doi: 10.1038/s41580-023-00647-2. Epub 2023 Sep 8. PMID: 37684425.

216．Xi J, Ding D, Zhu H, Wang R, Su F, Wu W, Xiao Z, Liang X, Zhao Q, Hong Z, Fu H, Xiao Q. Disturbed microbial ecology in Alzheimer's disease: evidence from the gut microbiota and fecal metabolome. BMC Microbiol. 2021 Aug 12;21(1):226. doi: 10.1186/s12866-021-02286-z. PMID: 34384375; PMCID: PMC8361629.

217．Schächtle MA, Rosshart SP. The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research. Front Cell Neurosci. 2021 Jul 15;15:698172. doi: 10.3389/fncel.2021.698172. PMID: 34335190; PMCID: PMC8321234.

218．Bettcher BM, Tansey MG, Dorothée G, Heneka MT. Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nat Rev Neurol. 2021 Nov;17(11):689-701. doi: 10.1038/s41582-021-00549-x. Epub 2021 Sep 14. Erratum in: Nat Rev Neurol. 2021 Nov;17(11):724. doi: 10.1038/s41582-021-00579-5. PMID: 34522039; PMCID: PMC8439173.

219．Fan X, Liu B, Zhou J, Gu X, Zhou Y, Yang Y, Guo F, Wei X, Wang H, Si N, Yang J, Bian B, Zhao H. High-Fat Diet Alleviates Neuroinflammation and Metabolic Disorders of APP/PS1 Mice and the Intervention With Chinese Medicine. Front Aging Neurosci. 2021 Jun 8;13:658376. doi: 10.3389/fnagi.2021.658376. PMID: 34168550; PMCID: PMC8217439.

220．Konecny J, Misiachna A, Hrabinova M, Pulkrabkova L, Benkova M, Prchal L, Kucera T, Kobrlova T, Finger V, Kolcheva M, Kortus S, Jun D, Valko M, Horak M, Soukup O, Korabecny J. Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors andN-Methyl-d-Aspartate Receptor Antagonists. Biomolecules. 2020 Dec 22;11(1):3. doi: 10.3390/biom11010003. PMID: 33375115; PMCID: PMC7822176.

221．Zhang Y, Jia Z, Wang J, Liang H. Research Hotspots and Frontiers of Alzheimer's Disease and Gut Microbiota: A Knowledge Mapping and Text Mining Analysis. Mol Neurobiol. 2024 Nov;61(11):9369-9382. doi: 10.1007/s12035-024-04168-7. Epub 2024 Apr 18. PMID: 38632152.

222．Wang C, Hao J, Liu X, Li C, Yuan X, Lee RJ, Bai T, Wang D. Isoforsythiaside Attenuates Alzheimer's Disease via Regulating Mitochondrial Function Through the PI3K/AKT Pathway. Int J Mol Sci. 2020 Aug 8;21(16):5687. doi: 10.3390/ijms21165687. PMID: 32784451; PMCID: PMC7460834.

223．Gao D, Li P, Gao F, Feng Y, Li X, Li D, Li Y, Xiao Y. Preparation and Multitarget Anti-AD Activity Study of Chondroitin Sulfate Lithium in AD Mice Induced by Combination of D-Gal/AlCl₃. Oxid Med Cell Longev. 2022 Nov12;2022:9466166. doi: 10.1155/2022/9466166. PMID: 36411758; PMCID: PMC9675613.

224．Huang Y, Wang Z, Ma H, Ji S, Chen Z, Cui Z, Chen J, Tang S. Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy. Front Cell Infect Microbiol. 2021 Mar 19;11:646348. doi: 10.3389/fcimb.2021.646348. PMID: 33816351; PMCID: PMC8017229.

225．Sun L, Xu M, Shi Y, Xu Y, Chen J, He L. Decoding psychosis: from national genome project to national brain project. Gen Psychiatr. 2022 Sep 22;35(4):e100889. doi: 10.1136/gpsych-2022-100889. PMID: 36248024; PMCID: PMC9511649.

226．Li ZL, Ma HT, Wang M, Qian YH. Research trend of microbiota-gut-brain axis in Alzheimer's disease based on CiteSpace (2012-2021): A bibliometrics analysis of 608 articles. Front Aging Neurosci. 2022 Nov 22;14:1036120. doi: 10.3389/fnagi.2022.1036120. PMID: 36483116; PMCID: PMC9724362.

227．Jannat K, Balakrishnan R, Han JH, Yu YJ, Kim GW, Choi DK. The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source. Cells. 2023 Nov 18;12(22):2652. doi: 10.3390/cells12222652. PMID: 37998387; PMCID: PMC10670678.

228．Abitbol A, Mallard B, Tiralongo E, Tiralongo J. Mushroom Natural Products in Neurodegenerative Disease Drug Discovery. Cells. 2022 Dec 6;11(23):3938. doi: 10.3390/cells11233938. PMID: 36497196; PMCID: PMC9740391.

229．Gao JM, Zhang X, Shu GT, Chen NN, Zhang JY, Xu F, Li F, Liu YG, Wei Y, He YQ, Shi JS, Gong QH. Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway. Acta Pharmacol Sin. 2022 Oct;43(10):2482-2494. doi: 10.1038/s41401-022-00888-5. Epub 2022 Mar 15. PMID: 35292770; PMCID: PMC9525711.

230．Guo Y, Xu Y, Lin X, Zhen Z, Yi F, Guan H, Shi Q, Sun W, Yang A, Dong X, Wang J. Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota. Front Neurol. 2022 Apr 15;13:832599. doi: 10.3389/fneur.2022.832599. PMID: 35493823; PMCID: PMC9051076.

231．Shandilya S, Kumar S, Kumar Jha N, Kumar Kesari K, Ruokolainen J. Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection. J Adv Res. 2021 Sep 17;38:223-244. doi: 10.1016/j.jare.2021.09.005. PMID: 35572407; PMCID: PMC9091761.

232．Fang C, Zuo K, Zhang W, Zhong J, Li J, Xu L, Yang X. Association between Gut Microbiota Dysbiosis and the CHA2DS2-VASc Score in Atrial Fibrillation Patients. Int J Clin Pract. 2022 May 6;2022:7942605. doi: 10.1155/2022/7942605. PMID: 35685549; PMCID: PMC9159190.

233．Saiyasit N, Butlig ER, Chaney SD, Traylor MK, Hawley NA, Randall RB, Bobinger HV, Frizell CA, Trimm F, Crook ED, Lin M, Hill BD, Keller JL, Nelson AR. Neurovascular Dysfunction in Diverse Communities With Health Disparities- Contributions to Dementia and Alzheimer's Disease. Front Neurosci. 2022 Jun 29;16:915405. doi: 10.3389/fnins.2022.915405. PMID: 35844216; PMCID: PMC9279126.

234．Hochuli N, Kadyan S, Park G, Patoine C, Nagpal R. Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer's pathophysiology. Microbiome Res Rep. 2023 Dec 6;3(1):9. doi: 10.20517/mrr.2023.39. PMID: 38455083; PMCID: PMC10917618.

235．Wu YL, Xu J, Rong XY, Wang F, Wang HJ, Zhao C. Gut microbiota alterations and health status in aging adults: From correlation to causation. Aging Med (Milton). 2021 Jun 24;4(3):206-213. doi: 10.1002/agm2.12167. PMID: 34553118;PMCID: PMC8444961.

236．Liu N, Jiang X, Li H. The viral hypothesis in Alzheimer's disease: SARS- CoV-2 on the cusp. Front Aging Neurosci. 2023 Mar 15;15:1129640. doi: 10.3389/fnagi.2023.1129640. PMID: 37009449; PMCID: PMC10050697.

237．Cummings J. Drug Development for Psychotropic, Cognitive-Enhancing, and Disease-Modifying Treatments for Alzheimer's Disease. J Neuropsychiatry Clin Neurosci. 2021 Winter;33(1):3-13. doi: 10.1176/appi.neuropsych.20060152. Epub 2020 Oct 28. PMID: 33108950; PMCID: PMC7989572.

238．Huang L, Thonusin C, Chattipakorn N, Chattipakorn SC. Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review. Eur J Nutr. 2021 Aug;60(5):2343-2360. doi: 10.1007/s00394-021-02483-6. Epub 2021 Jan 29. PMID: 33512587.

239．Zhang F, Zhong RJ, Cheng C, Li S, Le WD. New therapeutics beyond amyloid-βand tau for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2021 Sep;42(9):1382-1389. doi: 10.1038/s41401-020-00565-5. Epub 2020 Dec 2. PMID: 33268824; PMCID: PMC8379190.

240．Capocchi JK, Figueroa-Romero C, Dunham SJB, Faraci G, Rothman JA, Whiteson KL, Seo DO, Holtzman DM, Grabrucker S, Nolan YM, Kaddurah-Daouk R, Jett DA.Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD? J Neurosci. 2024 Oct 9;44(41):e1295242024. doi: 10.1523/JNEUROSCI.1295-24.2024. PMID: 39384409; PMCID: PMC11466070.

241．Almeida ZL, Vaz DC, Brito RMM. Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis. Mol Neurobiol. 2025 Apr;62(4):4391-4419. doi: 10.1007/s12035-024-04543-4. Epub 2024 Oct 24. PMID: 39446217; PMCID: PMC11880078.

242．Schaible P, Henschel J, Erny D. How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells. J Neuroinflammation. 2025 Mar 3;22(1):60. doi: 10.1186/s12974-025-03371-0. PMID: 40033338; PMCID: PMC11877772.

243．Xie Z, Tong S, Chu X, Feng T, Geng M. Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis. Kidney Dis (Basel). 2022 May 3;8(4):275-285. doi: 10.1159/000524475. PMID: 36157262; PMCID: PMC9386403.

244．Guo M, Wang X, Li Y, Luo A, Zhao Y, Luo X, Li S. Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota. Nutrients. 2023 Nov 24;15(23):4915. doi: 10.3390/nu15234915. PMID: 38068773; PMCID: PMC10707790.

245．Qian Z, Li Y, Hao Z, Zheng Z, Yang H, Li S, Xu S, Xu Y, Zhang L. Enhancement of the organic acid content and antioxidant capacity of yellow whey through fermentation with Lacticaseibacillus casei YQ336. World J Microbiol Biotechnol. 2023 Dec 26;40(2):53. doi: 10.1007/s11274-023-03874-z. PMID: 38146044.

246．Teng J, Zhao Y, Jiang Y, Wang Q, Zhang Y. [Correlation between Gut Microbiota and Lung Cancer]. Zhongguo Fei Ai Za Zhi. 2020 Oct 20;23(10):909-915. Chinese. doi: 10.3779/j.issn.1009-3419.2020.101.39. Epub 2020 Aug 17. PMID: 32798442; PMCID: PMC7583874.

247．Onyango IG, Jauregui GV, Čarná M, Bennett JP Jr, Stokin GB. Neuroinflammation in Alzheimer's Disease. Biomedicines. 2021 May 7;9(5):524. doi: 10.3390/biomedicines9050524. PMID: 34067173; PMCID: PMC8150909.

248．Narengaowa, Kong W, Lan F, Awan UF, Qing H, Ni J. The Oral-Gut-Brain AXIS:The Influence of Microbes in Alzheimer's Disease. Front Cell Neurosci. 2021 Apr14;15:633735. doi: 10.3389/fncel.2021.633735. PMID: 33935651; PMCID: PMC8079629.

249．Zhang X, Tang B, Guo J. Parkinson's disease and gut microbiota: from clinical to mechanistic and therapeutic studies. Transl Neurodegener. 2023 Dec 15;12(1):59. doi: 10.1186/s40035-023-00392-8. PMID: 38098067; PMCID: PMC10722742.

250．Sun YX, Jiang XJ, Lu B, Gao Q, Chen YF, Wu DB, Zeng WY, Yang L, Li HH, YuB. Roles of Gut Microbiota in Pathogenesis of Alzheimer's Disease and Therapeutic Effects of Chinese Medicine. Chin J Integr Med. 2022 Nov;28(11):1048-1056. doi: 10.1007/s11655-020-3274-5. Epub 2020 Sep 1. PMID: 32876860.

251．Giovannini MG, Lana D, Traini C, Vannucchi MG. The Microbiota-Gut-Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells. J Clin Med. 2021 May 27;10(11):2358. doi: 10.3390/jcm10112358. PMID: 34072107; PMCID: PMC8199461.

252．Shi J, Sabbagh MN, Vellas B. Alzheimer's disease beyond amyloid: strategies for future therapeutic interventions. BMJ. 2020 Oct 9;371:m3684. doi: 10.1136/bmj.m3684. PMID: 33036984; PMCID: PMC7541037.

253．Dai CL, Liu F, Iqbal K, Gong CX. Gut Microbiota and Immunotherapy for Alzheimer's Disease. Int J Mol Sci. 2022 Dec 3;23(23):15230. doi: 10.3390/ijms232315230. PMID: 36499564; PMCID: PMC9741026.

254．Amat S, Dahlen CR, Swanson KC, Ward AK, Reynolds LP, Caton JS. Bovine Animal Model for Studying the Maternal Microbiome, in utero Microbial Colonization and Their Role in Offspring Development and Fetal Programming. Front Microbiol. 2022 Feb 23;13:854453. doi: 10.3389/fmicb.2022.854453. PMID: 35283808; PMCID: PMC8916045.

255．Seo DO, Holtzman DM. Gut Microbiota: From the Forgotten Organ to a Potential Key Player in the Pathology of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):1232-1241. doi: 10.1093/gerona/glz262. PMID: 31738402; PMCID: PMC7302187.

256．Xu Z, Yang H, Li X, Xu X, Tan H, Leng X. Dietary effects of aucubin on growth and flesh quality of grass carp (Ctenopharyngodon idellus) based on metabolomics. J Anim Sci. 2022 Oct 1;100(10):skac273. doi: 10.1093/jas/skac273. PMID: 35985277; PMCID: PMC9615150.

257．Morató X, Pytel V, Jofresa S, Ruiz A, Boada M. Symptomatic and Disease- Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach. Int J Mol Sci. 2022 Aug 18;23(16):9305. doi: 10.3390/ijms23169305. PMID: 36012569; PMCID: PMC9409252.

258．Li J, Shan W, Zuo Z. Co-housing with Alzheimer's disease mice induces changes in gut microbiota and impairment of learning and memory in control mice. CNS Neurosci Ther. 2024 Apr;30(4):e14491. doi: 10.1111/cns.14491. Epub 2023 Oct 3. PMID: 37789692; PMCID: PMC11017403.

259．Pan C, Zhang H, Zhang L, Chen L, Xu L, Xu N, Liu X, Meng Q, Wang X, Zhang ZY. Surgery-induced gut microbial dysbiosis promotes cognitive impairment via regulation of intestinal function and the metabolite palmitic amide. Microbiome. 2023 Nov 8;11(1):248. doi: 10.1186/s40168-023-01689-6. PMID: 37936242; PMCID:PMC10631187.

260．Kim AY, Al Jerdi S, MacDonald R, Triggle CR. Alzheimer's disease and its treatment-yesterday, today, and tomorrow. Front Pharmacol. 2024 May 24;15:1399121. doi: 10.3389/fphar.2024.1399121. PMID: 38868666; PMCID: PMC11167451.

261．Franzoni F, Cammisuli DM, Scarfò G, Castelnuovo G. Exploring Neurocognitive Deterioration in Alzheimer's Disease. Biology (Basel). 2023 Feb 21;12(3):343.doi: 10.3390/biology12030343. PMID: 36979035; PMCID: PMC10045858.

262．Liu Y, Li H, Wang X, Huang J, Zhao D, Tan Y, Zhang Z, Zhang Z, Zhu L, Wu B,Chen Z, Peng W. Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology. J Transl Med. 2023 Apr 24;21(1):277. doi: 10.1186/s12967-023-04137-z. PMID: 37095548; PMCID: PMC10124026.

263．Kwon C, Ediriweera MK, Kim Cho S. Interplay between Phytochemicals and the Colonic Microbiota. Nutrients. 2023 Apr 20;15(8):1989. doi: 10.3390/nu15081989.PMID: 37111207; PMCID: PMC10145007.

264．Xu W, Lv Z, Guo Q, Deng Z, Yang C, Cao Z, Li Y, Huang C, Wu Z, Chen S, He Y, Sun J, Liu Y, Gan L. Selective Antagonism of Lactiplantibacillus plantarum and Pediococcus acidilactici against Vibrio and Aeromonas in the Bacterial Community of Artemia nauplii. Microbiol Spectr. 2023 Aug 17;11(4):e0053323. doi: 10.1128/spectrum.00533-23. Epub 2023 Jul 10. PMID: 37428079; PMCID: PMC10434253.

265．Zheng R, Shi S, Zhang Q, Yuan S, Guo T, Guo J, Jiang P. Molecular mechanisms of Huanglian Jiedu decoction in treating Alzheimer's disease by regulating microbiome via network pharmacology and molecular docking analysis. Front Cell Infect Microbiol. 2023 Mar 16;13:1140945. doi: 10.3389/fcimb.2023.1140945. PMID: 37009506; PMCID: PMC10060893.

266．Rutsch A, Kantsjö JB, Ronchi F. The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Front Immunol. 2020 Dec 10;11:604179. doi: 10.3389/fimmu.2020.604179. PMID: 33362788; PMCID: PMC7758428.

267．Santangelo MC, Iacopini D, Favero L, Zecchi R, Pieraccini G, Di Pietro S, Di Bussolo V. One-Pot Stereospecific Synthesis of 1,4-Oligosaccharides by Glycal-Derived Vinyl Epoxides Assembly. ACS Omega. 2024 Oct 31;9(45):45047-45052. doi: 10.1021/acsomega.4c05247. PMID: 39554454; PMCID: PMC11561766.

268．Moelgg K, Jummun F, Humpel C. Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons. Biomolecules. 2021 Mar 15;11(3):434. doi: 10.3390/biom11030434. PMID: 33804246; PMCID: PMC7999593.

269．Sălcudean A, Bodo CR, Popovici RA, Cozma MM, Păcurar M, Crăciun RE, Crisan AI, Enatescu VR, Marinescu I, Cimpian DM, Nan AG, Sasu AB, Anculia RC, Strete EG. Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review. Biomolecules. 2025 Mar 30;15(4):502. doi: 10.3390/biom15040502. PMID: 40305200; PMCID: PMC12024626.

270．Liu S, Gao J, Zhu M, Liu K, Zhang HL. Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment. Mol Neurobiol. 2020 Dec;57(12):5026-5043. doi: 10.1007/s12035-020-02073-3. Epub 2020 Aug 23. PMID: 32829453; PMCID: PMC7541367.

271．Zhao K, Zhang H, Wu Y, Liu J, Li X, Lin J. Integrated analysis and identification of hub genes as novel biomarkers for Alzheimer's disease. Front Aging Neurosci. 2022 Aug 30;14:901972. doi: 10.3389/fnagi.2022.901972. PMID: 36110430; PMCID: PMC9468260.

272．Cao Y, Yu F, Lyu Y, Lu X. Promising candidates from drug clinical trials: Implications for clinical treatment of Alzheimer's disease in China. Front Neurol. 2022 Nov 15;13:1034243. doi: 10.3389/fneur.2022.1034243. PMID: 36457865;PMCID: PMC9706102.

273．Chen X, Chen X, Yan D, Zhang N, Fu W, Wu M, Ge F, Wang J, Li X, Geng M, Wang J, Tang D, Liu J. GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis. Nat Commun. 2024 Sep 27;15(1):8278. doi: 10.1038/s41467-024-52398-z. PMID: 39333064; PMCID: PMC11436807.

274．Sterling KG, Dodd GK, Alhamdi S, Asimenios PG, Dagda RK, De Meirleir KL, Hudig D, Lombardi VC. Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease. Int J Mol Sci. 2022 Nov 1;23(21):13328. doi: 10.3390/ijms232113328. PMID: 36362150; PMCID: PMC9655506.

275．Shahbazi R, Yasavoli-Sharahi H, Alsadi N, Ismail N, Matar C. Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders. Molecules. 2020 Oct 22;25(21):4891. doi: 10.3390/molecules25214891. PMID: 33105830; PMCID: PMC7660077.

276．Sun BL, Chen Y, Fan DY, Zhu C, Zeng F, Wang YJ. Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives. Sci China Life Sci. 2021 Jun;64(6):926-937. doi: 10.1007/s11427-020-1810-y. Epub 2020 Oct 23. PMID: 33106917.

277．Liu Y, Tan Y, Zhang Z, Yi M, Zhu L, Peng W. The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing. Transl Neurodegener. 2024 Jan 23;13(1):7. doi: 10.1186/s40035-024-00397-x. PMID: 38254235; PMCID: PMC10804662.

278．Sugita S, Tahir P, Kinjo S. The effects of microbiome-targeted therapy on cognitive impairment and postoperative cognitive dysfunction-A systematic review. PLoS One. 2023 Feb 7;18(2):e0281049. doi: 10.1371/journal.pone.0281049. PMID: 36749772; PMCID: PMC9904456.

279．Wang C, Chen S, Guo H, Jiang H, Liu H, Fu H, Wang D. Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation. Int J Biol Sci. 2022 Feb 28;18(5):2075-2090. doi: 10.7150/ijbs.69714. PMID: 35342364; PMCID: PMC8935224.

280．Song C, Shi J, Zhang P, Zhang Y, Xu J, Zhao L, Zhang R, Wang H, Chen H. Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond. Transl Neurodegener. 2022 Mar 18;11(1):18. doi: 10.1186/s40035-022-00292-3. PMID: 35300725; PMCID: PMC8932191.

281．Wang Y, Chen J, Wang X, Guo C, Peng X, Liu Y, Li T, Du J. Novel investigations in retinoic-acid-induced cleft palate about the gut microbiome of pregnant mice. Front Cell Infect Microbiol. 2022 Dec 15;12:1042779. doi: 10.3389/fcimb.2022.1042779. PMID: 36590585; PMCID: PMC9798234.

282．Chandra S, Sisodia SS, Vassar RJ. The gut microbiome in Alzheimer's disease: what we know and what remains to be explored. Mol Neurodegener. 2023 Feb 1;18(1):9. doi: 10.1186/s13024-023-00595-7. PMID: 36721148; PMCID: PMC9889249.

283．Asbjornsdottir B, Miranda-Ribera A, Fiorentino M, Konno T, Cetinbas M, Lan J, Sadreyev RI, Gudmundsson LS, Gottfredsson M, Lauth B, Birgisdottir BE, Fasano A. Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice. Biomedicines. 2022 Dec 29;11(1):91. doi: 10.3390/biomedicines11010091. PMID: 36672598; PMCID: PMC9855927.

284．Tang L, Bao M, Wang Y, Fu Z, Han F, Yu W. Effects of Module Truncation of a New Alginate Lyase VxAly7C from Marine Vibrio xiamenensis QY104 on Biochemical Characteristics and Product Distribution. Int J Mol Sci. 2022 Apr 27;23(9):4795. doi: 10.3390/ijms23094795. PMID: 35563187; PMCID: PMC9102848.

285．Zhu M, Liu X, Ye Y, Yan X, Cheng Y, Zhao L, Chen F, Ling Z. Gut Microbiota:A Novel Therapeutic Target for Parkinson's Disease. Front Immunol. 2022 Jun24;13:937555. doi: 10.3389/fimmu.2022.937555. PMID: 35812394; PMCID: PMC9263276.

286．Gao Y, Xu Y, Yin J. Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose- Treated Mice. Antioxidants (Basel). 2022 Jan 4;11(1):111. doi: 10.3390/antiox11010111. PMID: 35052615; PMCID: PMC8772940.

287．Versace S, Pellitteri G, Sperotto R, Tartaglia S, Da Porto A, Catena C, Gigli GL, Cavarape A, Valente M. A State-of-Art Review of the Vicious Circle of Sleep Disorders, Diabetes and Neurodegeneration Involving Metabolism and Microbiota Alterations. Int J Mol Sci. 2023 Jun 25;24(13):10615. doi: 10.3390/ijms241310615. PMID: 37445790; PMCID: PMC10341533.

288．Shen X, Wang B, Zi C, Huang L, Wang Q, Zhou C, Wen W, Liu K, Yuan W, Li X.Interaction and Metabolic Function of Microbiota during the Washed Processing of Coffea arabica. Molecules. 2023 Aug 16;28(16):6092. doi: 10.3390/molecules28166092. PMID: 37630344; PMCID: PMC10458683.

289．Xiu R, Sun Q, Li B, Wang Y. Mapping Research Trends and Hotspots in the Link between Alzheimer's Disease and Gut Microbes over the Past Decade: A Bibliometric Analysis. Nutrients. 2023 Jul 19;15(14):3203. doi: 10.3390/nu15143203. PMID: 37513621; PMCID: PMC10383611.

290．Ahmed H, Leyrolle Q, Koistinen V, Kärkkäinen O, Layé S, Delzenne N, Hanhineva K. Microbiota-derived metabolites as drivers of gut-brain communication. Gut Microbes. 2022 Jan-Dec;14(1):2102878. doi: 10.1080/19490976.2022.2102878. PMID: 35903003; PMCID: PMC9341364.

291．Shao L, Li X, Xiao T, Lu T, Li J, Deng J, Xiao E. Variations in microbial assemblage between rhizosphere and root endosphere microbiomes contribute to host plant growth under cadmium stress. Appl Environ Microbiol. 2023 Nov 29;89(11):e0096023. doi: 10.1128/aem.00960-23. Epub 2023 Oct 19. PMID: 37855640;PMCID: PMC10686079.

292．Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G. Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. J Neuroinflammation. 2020 May 25;17(1):165. doi: 10.1186/s12974-020-01830-4. PMID: 32450897; PMCID: PMC7247752.

293．He S, Zhang R, Wang R, Wu D, Dai S, Wang Z, Chen T, Mao H, Li Q. Responses of nutrient utilization, rumen fermentation and microorganisms to different roughage of dairy buffaloes. BMC Microbiol. 2024 May 29;24(1):188. doi: 10.1186/s12866-024-03342-0. PMID: 38811906; PMCID: PMC11134657.

294．Hernandez AR, Hoffman JM, Hernandez CM, Cortes CJ, Jumbo-Lucioni P, Baxter MG, Esser KA, Liu AC, McMahon LL, Bizon JL, Burke SN, Buford TW, Carter CS. Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):e1-e9. doi: 10.1093/gerona/glab215. PMID: 34309630; PMCID: PMC8751793.

295．Serafin P, Zaremba M, Sulejczak D, Kleczkowska P. Air Pollution: A Silent Key Driver of Dementia. Biomedicines. 2023 May 18;11(5):1477. doi: 10.3390/biomedicines11051477. PMID: 37239148; PMCID: PMC10216517.

296．Pan RY, Zhang J, Wang J, Wang Y, Li Z, Liao Y, Liao Y, Zhang C, Liu Z, Song L, Yu J, Yuan Z. Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota. Nat Aging. 2022 Nov;2(11):1024-1039. doi: 10.1038/s43587-022-00311-y. Epub 2022 Nov 17. PMID: 37118092.

297．Dong X, Hao X, Wen J, Yan Q, Ma K, Liu Q, Li J, Zhang L. Study on the mechanism of acupuncture to improve mild cognitive impairment in hypertension by regulating intestinal microbiome. Front Neurosci. 2024 Dec 23;18:1495384. doi: 10.3389/fnins.2024.1495384. PMID: 39764388; PMCID: PMC11701057.

298．Bai J, Zeng Q, Den W, Huang L, Wu Z, Li X, Tong P, Chen H, Yang A. Synergistic Synbiotic-Containing Lactiplantibacillus plantarum and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein. Foods. 2025 Jan 2;14(1):109. doi: 10.3390/foods14010109. PMID: 39796399; PMCID: PMC11720218.

299．Nie T, You L, Tang F, Duan Y, Nepovimova E, Kuca K, Wu Q, Wei W. Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases. Curr Neuropharmacol. 2025;23(5):524-546. doi: 10.2174/1570159X23666241101093436. PMID: 39501955.

300．Xing H, Yue S, Qin R, Du X, Wu Y, Zhangsun D, Luo S. Recent Advances in Drug Development for Alzheimer's Disease: A Comprehensive Review. Int J Mol Sci. 2025 Apr 21;26(8):3905. doi: 10.3390/ijms26083905. PMID: 40332804; PMCID: PMC12028297.

301．Roy B, Cao K, Singh CO, Fang X, Yang H, Wei D. Advances in gut microbiota- related treatment strategies for managing colorectal cancer in humans. Cancer Biol Med. 2025 Mar 12;22(2):93–112. doi: 10.20892/j.issn.2095-3941.2024.0263. PMID: 40072039; PMCID: PMC11899591.

302．Pokrzyk J, Kulczyńska-Przybik A, Guzik-Makaruk E, Winkel I, Mroczko B. Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer's Disease. Int J Mol Sci. 2025 Feb 24;26(5):1935. doi: 10.3390/ijms26051935. PMID: 40076562; PMCID: PMC11900921.

303．Wang XS, Li JJ, Wang YS, Yu CC, He C, Huang ZS, Jiang T, Hao Q, Kong LH. Acupuncture and Related Therapies for the Cognitive Function of Alzheimer's Disease: A Network Meta-Analysis. Iran J Public Health. 2021 Dec;50(12):2411-2426. doi: 10.18502/ijph.v50i12.7924. PMID: 36317033; PMCID: PMC9577142.

304．Cao X, Du X, Jiao H, An Q, Chen R, Fang P, Wang J, Yu B. Carbohydrate-based drugs launched during 2000-2021. Acta Pharm Sin B. 2022 Oct;12(10):3783-3821. doi: 10.1016/j.apsb.2022.05.020. Epub 2022 May 23. PMID: 36213536; PMCID: PMC9532563.

305．Zhang T, Dong K, Xiao L, Li G, Zhang Z. Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer's Disease. Neuropsychiatr Dis Treat. 2020 Sep 22;16:2169-2179. doi: 10.2147/NDT.S253972. PMID: 33061388; PMCID: PMC7519864.

306．Ngu EL, Tan CY, Lai NJ, Wong KH, Lim SH, Ming LC, Tan KO, Phang SM, Yow YY.Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia. Metabolites. 2022 Nov 20;12(11):1147. doi: 10.3390/metabo12111147. PMID: 36422287; PMCID: PMC9698046.

307．Huang L, Zeng Y, Li Y, Zhu Y, He Y, Liu Y, Robert A, Meunier B. Distribution in Rat Blood and Brain of TDMQ20, a Copper Chelator Designed as a Drug-Candidate for Alzheimer's Disease. Pharmaceutics. 2022 Dec 1;14(12):2691. doi: 10.3390/pharmaceutics14122691. PMID: 36559185; PMCID: PMC9785178.

308．Botchway BO, Okoye FC, Chen Y, Arthur WE, Fang M. Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents. Aging Dis. 2022 Feb 1;13(1):87-102. doi:10.14336/AD.2021.0616. PMID: 35111364; PMCID: PMC8782546.

309．Wang M, Zhang H, Liang J, Huang J, Chen N. Exercise suppresses neuroinflammation for alleviating Alzheimer's disease. J Neuroinflammation. 2023 Mar 19;20(1):76. doi: 10.1186/s12974-023-02753-6. PMID: 36935511; PMCID: PMC10026496.

310．Song S, Lou Y, Mao Y, Wen X, Fan M, He Z, Shen Y, Wen C, Shao T. Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice. Front Immunol. 2022 Feb 7;13:804306. doi: 10.3389/fimmu.2022.804306. PMID: 35197978; PMCID:PMC8858814.

311．Hu D, Jin Y, Hou X, Zhu Y, Chen D, Tai J, Chen Q, Shi C, Ye J, Wu M, Zhang H, Lu Y. Application of Marine Natural Products against Alzheimer's Disease: Past, Present and Future. Mar Drugs. 2023 Jan 5;21(1):43. doi: 10.3390/md21010043. PMID: 36662216; PMCID: PMC9867307.

312．Ayan E, DeMirci H, Serdar MA, Palermo F, Baykal AT. Bridging the Gap between Gut Microbiota and Alzheimer's Disease: A Metaproteomic Approach for Biomarker Discovery in Transgenic Mice. Int J Mol Sci. 2023 Aug 15;24(16):12819. doi: 10.3390/ijms241612819. PMID: 37629000; PMCID: PMC10454110.

313．Zhang B, Chen T, Cao M, Yuan C, Reiter RJ, Zhao Z, Zhao Y, Chen L, Fan W, Wang X, Zhou X, Li C. Gut Microbiota Dysbiosis Induced by Decreasing Endogenous Melatonin Mediates the Pathogenesis of Alzheimer's Disease and Obesity. Front Immunol. 2022 May 10;13:900132. doi: 10.3389/fimmu.2022.900132. PMID: 35619714; PMCID: PMC9127079.

314．Zhang Z, Guo P, Huang S, Jia Z, Chen T, Liu X, Feng H, Chen Y. Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway. Oxid Med Cell Longev. 2022 May 17;2022:4177317. doi: 10.1155/2022/4177317. PMID: 35620574; PMCID: PMC9129981.

315．Li Y, Shao L, Mou Y, Zhang Y, Ping Y. Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer's disease and their potential links in the pathogenesis. Gut Microbes. 2021 Jan-Dec;13(1):1957407. doi: 10.1080/19490976.2021.1957407. PMID: 34520319; PMCID: PMC8463034.

316．Chen Y, Lai M, Tao M. Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review. Medicine (Baltimore). 2024 Apr 19;103(16):e37799. doi: 10.1097/MD.0000000000037799. PMID: 38640313; PMCID:PMC11029996.

317．Benichou Haziot C, Birak KS. Therapeutic Potential of Microbiota Modulation in Alzheimer's Disease: A Review of Preclinical Studies. J Alzheimers Dis Rep. 2023 May 12;7(1):415-431. doi: 10.3233/ADR-220097. PMID: 37220623; PMCID: PMC10200201.

318．Fu Y, Wang Y, Ren H, Guo X, Han L. Branched-chain amino acids and the risks of dementia, Alzheimer's disease, and Parkinson's disease. Front Aging Neurosci. 2024 Apr 10;16:1369493. doi: 10.3389/fnagi.2024.1369493. PMID: 38659706; PMCID:PMC11040674.

319．Valentino TR, Burke BI, Kang G, Goh J, Dungan CM, Ismaeel A, Mobley CB, Flythe MD, Wen Y, McCarthy JJ. Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy. bioRxiv [Preprint]. 2024 Jun 2:2024.05.29.596432. doi: 10.1101/2024.05.29.596432. PMID: 38854012; PMCID: PMC11160717.

320．Zhu G, Zhao J, Zhang H, Wang G, Chen W. Gut Microbiota and its Metabolites:Bridge of Dietary Nutrients and Alzheimer's Disease. Adv Nutr. 2023 Jul;14(4):819-839. doi: 10.1016/j.advnut.2023.04.005. Epub 2023 Apr 17. PMID: 37075947; PMCID: PMC10334159.

321．Zhu CC, Fu SY, Chen YX, Li L, Mao RL, Wang JZ, Liu R, Liu Y, Wang XC. Advances in Drug Therapy for Alzheimer's Disease. Curr Med Sci. 2020 Dec;40(6):999-1008. doi: 10.1007/s11596-020-2281-2. Epub 2021 Jan 11. PMID: 33428127.

322．Gao Y, Lu Y, Liang X, Zhao M, Yu X, Fu H, Yang W. CD4⁺ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets. Cells. 2024 Apr 25;13(9):749. doi: 10.3390/cells13090749. PMID: 38727285; PMCID: PMC11083511.

323．Zhu Y, Xu H, Yu C, Jiang W, Hou X, Ma M, Wu J. Polymers for the treatment of Alzheimer's disease. Front Pharmacol. 2025 Jan 29;16:1512941. doi: 10.3389/fphar.2025.1512941. PMID: 39944627; PMCID: PMC11813879.

324．Chen X, Wang B, Al Mamun A, Du K, Wang S, Hu Q, Chen X, Lu Y, Du A, Wu Y, Shao J, Wang S, Jiang C, Zhou K, Hu S, Xiao J. Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury. J Nanobiotechnology. 2025 Feb 28;23(1):152. doi: 10.1186/s12951-025-03224-1. PMID: 40016738; PMCID: PMC11869623.

325．Wang H, Wen J, Ablimit N, Deng K, Wang W, Jiang W. Degradation of Natural Undaria pinnatifida into Unsaturated Guluronic Acid Oligosaccharides by a Single Alginate Lyase. Mar Drugs. 2024 Oct 2;22(10):453. doi: 10.3390/md22100453. PMID: 39452861; PMCID: PMC11509462.

326．Zhu G, Guo M, Zhao J, Zhang H, Wang G, Chen W. Bifidobacterium breveintervention combined with environmental enrichment alleviates cognitive impairment by regulating the gut microbiota and microbial metabolites in Alzheimer's disease mice. Front Immunol. 2022 Sep 20;13:1013664. doi: 10.3389/fimmu.2022.1013664. PMID: 36203603; PMCID: PMC9530393.

327．Zhang L, Jiang Z, Hu S, Ni H, Zhao Y, Tan X, Lang Y, Na R, Li Y, Du Q, Li QX, Dong Y. GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice. Inflammation. 2024 Aug 24. doi:10.1007/s10753-024-02133-z. Epub ahead of print. PMID: 39180577.

328．Bulgart HR, Neczypor EW, Wold LE, Mackos AR. Microbial involvement in Alzheimer disease development and progression. Mol Neurodegener. 2020 Jul 24;15(1):42. doi: 10.1186/s13024-020-00378-4. PMID: 32709243; PMCID: PMC7382139.

329．Guo Y, Wang S, Chao X, Li D, Wang Y, Guo Q, Chen T. Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases. Front Aging Neurosci. 2022 Oct 31;14:1026688. doi: 10.3389/fnagi.2022.1026688. PMID: 36389059; PMCID: PMC9659972.

330．Zhan T, Wu Y, Deng X, Li Q, Chen Y, Lv J, Wang J, Li S, Wu Z, Liu D, Tang Z. Multi-omics approaches reveal the molecular mechanisms underlying the interaction between Clonorchis sinensis and mouse liver. Front Cell Infect Microbiol. 2023 Nov 24;13:1286977. doi: 10.3389/fcimb.2023.1286977. PMID:38076459; PMCID: PMC10710275.

331．Yao T, Fu L, Wu Y, Li L. Christensenella minuta Alleviates Acetaminophen-Induced Hepatotoxicity by Regulating Phenylalanine Metabolism. Nutrients. 2024 Jul 18;16(14):2314. doi: 10.3390/nu16142314. PMID: 39064757; PMCID: PMC11280030.

332．Zhu G, Zhao J, Zhang H, Chen W, Wang G. Administration ofBifidobacterium breve Improves the Brain Function of Aβ_1-42-Treated Mice via the Modulation of the Gut Microbiome. Nutrients. 2021 May 11;13(5):1602. doi: 10.3390/nu13051602. PMID: 34064762; PMCID: PMC8150793.

333．Rossi B, Santos-Lima B, Terrabuio E, Zenaro E, Constantin G. Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease. Front Immunol. 2021 Feb 19;12:639369. doi: 10.3389/fimmu.2021.639369. PMID: 33679799; PMCID: PMC7933037.

334．Liu N, Haziyihan A, Zhao W, Chen Y, Chao H. Trajectory of brain-derived amyloid beta in Alzheimer's disease: where is it coming from and where is it going? Transl Neurodegener. 2024 Aug 19;13(1):42. doi: 10.1186/s40035-024-00434-9. PMID: 39160618; PMCID: PMC11331646.

335．Shu Z, Wang G, Liu F, Xu Y, Sun J, Hu Y, Dong H, Zhang J. Genome Sequencing-Based Mining and Characterization of a Novel Alginate Lyase fromVibrio alginolyticus S10 for Specific Production of Disaccharides. Mar Drugs. 2023 Oct 27;21(11):564. doi: 10.3390/md21110564. PMID: 37999388; PMCID:PMC10672080.

336．Xu X, Jin W, Chang R, Ding X. Research progress of SREBP and its role in the pathogenesis of autoimmune rheumatic diseases. Front Immunol. 2024 Aug 19;15:1398921. doi: 10.3389/fimmu.2024.1398921. PMID: 39224584; PMCID: PMC11366632.

337．Li J, Liao X, Yin X, Deng Z, Hu G, Zhang W, Jiang F, Zhao L. Gut Microbiome and Serum Metabolome Profiles of Capsaicin with Cognitive Benefits in APP/PS1 Mice. Nutrients. 2022 Dec 27;15(1):118. doi: 10.3390/nu15010118. PMID: 36615777;PMCID: PMC9823564.

338．Forssten SD, Ouwehand AC, Griffin SM, Patterson E. One Giant Leap from Mouse to Man: The Microbiota-Gut-Brain Axis in Mood Disorders and Translational Challenges Moving towards Human Clinical Trials. Nutrients. 2022 Jan 27;14(3):568. doi: 10.3390/nu14030568. PMID: 35276927; PMCID: PMC8840472.

339．Li YC, Liu Y, Chen F, Chu M, Chen XC. [Relationship between Oral Microbiota and Alzheimer's Disease]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Mar;53(2):194-200. Chinese. doi: 10.12182/20220360304. PMID: 35332717; PMCID: PMC10409350.

340．Xu Q, Wen L, Wei G, Zhao X, Liu Y, Xiong W, Zhang T, Fan Y, Chen C, Xiang C, Chen C, Chen Y, Yin Q, Zhang TE, Yan Z. Marked Response of Rat Ileal and Colonic Microbiota After the Establishment of Alzheimer's Disease Model With Bilateral Intraventricular Injection of Aβ (1-42). Front Microbiol. 2022 Feb 11;13:819523. doi: 10.3389/fmicb.2022.819523. PMID: 35222337; PMCID: PMC8874218.

341．Gates EJ, Bernath AK, Klegeris A. Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases. Rev Neurosci. 2022 Mar 21;33(7):767-787. doi: 10.1515/revneuro-2021-0146. PMID: 35304983; PMCID: PMC9514114.

342．Li F, Wang Y, Song X, Wang Z, Jia J, Qing S, Huang L, Wang Y, Wang S, Ren Z, Zheng K, Wang Y. The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia. Gut Microbes. 2022 Jan-Dec;14(1):2096989. doi: 10.1080/19490976.2022.2096989. PMID:35793266; PMCID: PMC9262364.

343．Shin Y, Han S, Kwon J, Ju S, Choi TG, Kang I, Kim SS. Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease. Nutrients. 2023 Oct 21;15(20):4466. doi: 10.3390/nu15204466. PMID: 37892541; PMCID: PMC10609902.

344．Qian XH, Xie RY, Liu XL, Chen SD, Tang HD. Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease. Aging Dis. 2022 Jul 11;13(4):1252-1266. doi: 10.14336/AD.2021.1215. PMID: 35855330; PMCID: PMC9286902.

345．Gao D, Zhao H, Yin Z, Han C, Wang Y, Luo G, Gao X. Rheum tanguticum Alleviates Cognitive Impairment in APP/PS1 Mice by Regulating Drug-Responsive Bacteria and Their Corresponding Microbial Metabolites. Front Pharmacol. 2021 Dec 15;12:766120. doi: 10.3389/fphar.2021.766120. PMID: 34975476; PMCID:PMC8715007.

346．Lu M, Zhang Y, Wang S, Wang X, Zhang S, De J. Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China. PLoS One. 2023 Aug 25;18(8):e0290696. doi: 10.1371/journal.pone.0290696. PMID: 37624827; PMCID: PMC10456159.

347．Cheng Q, Ma X, Liu J, Feng X, Liu Y, Wang Y, Ni W, Song M. Pharmacological Inhibition of the Asparaginyl Endopeptidase (AEP) in an Alzheimer's Disease Model Improves the Survival and Efficacy of Transplanted Neural Stem Cells. Int J Mol Sci. 2023 Apr 23;24(9):7739. doi: 10.3390/ijms24097739. PMID: 37175445; PMCID: PMC10178525.

348．Bi FC, Yang XH, Cheng XY, Deng WB, Guo XL, Yang H, Wang Y, Li J, Yao Y. Optimization of cerebral organoids: a more qualified model for Alzheimer's disease research. Transl Neurodegener. 2021 Aug 9;10(1):27. doi: 10.1186/s40035-021-00252-3. PMID: 34372927; PMCID: PMC8349709.

349．Aziz N, Wal P, Patel A, Prajapati H. A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7307-7336. doi: 10.1007/s00210-024-03109-4. Epub 2024 May 11. PMID:38734839.

350．Zou B, Li J, Ma RX, Cheng XY, Ma RY, Zhou TY, Wu ZQ, Yao Y, Li J. Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer's Disease: A Systematic Review. Aging Dis. 2023 Jun 1;14(3):964-1678. doi: 10.14336/AD.2022.1127. PMID: 37191418; PMCID: PMC10187701.

351．Liu M, Guo H, Li Z, Zhang C, Zhang X, Cui Q, Tian J. Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer's Diseases. Front Aging Neurosci. 2020 Oct 23;12:601603. doi: 10.3389/fnagi.2020.601603. PMID: 33192493; PMCID: PMC7645199.

352．Li X, Quan M, Wei Y, Wang W, Xu L, Wang Q, Jia J. Critical thinking of Alzheimer's transgenic mouse model: current research and future perspective. Sci China Life Sci. 2023 Dec;66(12):2711-2754. doi: 10.1007/s11427-022-2357-x. Epub 2023 Jul 17. PMID: 37480469.

353．He J, Sun S, Wang H, Ying Z, Tam KY. Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease. Neurosci Bull. 2025 May;41(5):821-836. doi: 10.1007/s12264-025-01354-y. Epub 2025 Feb 5. PMID: 39907971; PMCID: PMC12014999.

354．Xiao J, Katsumata N, Bernier F, Ohno K, Yamauchi Y, Odamaki T, Yoshikawa K, Ito K, Kaneko T. Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2020;77(1):139-147. doi: 10.3233/JAD-200488. PMID: 32623402; PMCID: PMC7592675.

355．Liu E, Zhang Y, Wang JZ. Updates in Alzheimer's disease: from basic research to diagnosis and therapies. Transl Neurodegener. 2024 Sep 4;13(1):45. doi: 10.1186/s40035-024-00432-x. PMID: 39232848; PMCID: PMC11373277.

356．Ojeda J, Ávila A, Vidal PM. Gut Microbiota Interaction with the Central Nervous System throughout Life. J Clin Med. 2021 Mar 21;10(6):1299. doi: 10.3390/jcm10061299. PMID: 33801153; PMCID: PMC8004117.

357．Kim N, Ju IG, Jeon SH, Lee Y, Jung MJ, Gee MS, Cho JS, Inn KS, Garrett- Sinha LA, Oh MS, Lee JK. Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer's disease mouse model. J Neuroinflammation. 2023 Nov 27;20(1):282. doi: 10.1186/s12974-023-02966-9. PMID: 38012646; PMCID: PMC10680211.

358．Gao Q, Bi D, Li B, Ni M, Pang D, Li X, Zhang X, Xu Y, Zhao Q, Zhu C. The Association Between Branched-Chain Amino Acid Concentrations and the Risk of Autism Spectrum Disorder in Preschool-Aged Children. Mol Neurobiol. 2024 Aug;61(8):6031-6044. doi: 10.1007/s12035-024-03965-4. Epub 2024 Jan 24. PMID: 38265552; PMCID: PMC11249470.

359．Brandon-Mong GJ, Shaw GT, Chen WH, Chen CC, Wang D. A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model. BMC Microbiol. 2020 Sep 30;20(1):295. doi: 10.1186/s12866-020-01981-7. Erratum in: BMC Microbiol. 2020 Dec 28;20(1):377. doi: 10.1186/s12866-020-02048-3. PMID: 32998681; PMCID: PMC7525972.

360．Kuźniar J, Kozubek P, Czaja M, Leszek J. Correlation between Alzheimer's Disease and Gastrointestinal Tract Disorders. Nutrients. 2024 Jul 21;16(14):2366. doi: 10.3390/nu16142366. PMID: 39064809; PMCID: PMC11279885.

361．Dissanayaka DMS, Jayasena V, Rainey-Smith SR, Martins RN, Fernando WMADB. The Role of Diet and Gut Microbiota in Alzheimer's Disease. Nutrients. 2024 Jan 31;16(3):412. doi: 10.3390/nu16030412. PMID: 38337696; PMCID: PMC10857293.

362．Lee JG, Cho HJ, Jeong YM, Lee JS. Genetic Approaches Using Zebrafish to Study the Microbiota-Gut-Brain Axis in Neurological Disorders. Cells. 2021 Mar 5;10(3):566. doi: 10.3390/cells10030566. PMID: 33807650; PMCID: PMC8002147.

363．Gu X, Fan M, Zhou Y, Zhang Y, Wang L, Gao W, Li T, Wang H, Si N, Wei X, Bian B, Zhao H. Intestinal endogenous metabolites affect neuroinflammation in 5×FAD mice by mediating "gut-brain" axis and the intervention with Chinese Medicine. Alzheimers Res Ther. 2024 Oct 14;16(1):222. doi: 10.1186/s13195-024-01587-5. PMID: 39396997; PMCID: PMC11472645.

364．Lu MH, Ji WL, Chen H, Sun YY, Zhao XY, Wang F, Shi Y, Hu YN, Liu BX, Wu JW, Xu DE, Zheng JW, Liu CF, Ma QH. Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model. Front Aging Neurosci. 2021 Mar 10;13:650103. doi: 10.3389/fnagi.2021.650103. PMID:33776747; PMCID: PMC7987677.

365．Wu Y, Hang Z, Lei T, Du H. Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones. Neurochem Res. 2022 Dec;47(12):3565-3582. doi:10.1007/s11064-022-03784-w. Epub 2022 Oct 30. PMID: 36309938.

366．Liang S, Lu M, Yu D, Xing G, Ji Z, Guo Z, Zhang Q, Huang W, Xie M, Hou S. Effects of age on differential resistance to duck hepatitis A virus genotype 3 in Pekin ducks by 16 S and transcriptomics. Comput Struct Biotechnol J. 2024 Jan 17;23:771-782. doi: 10.1016/j.csbj.2024.01.005. PMID: 38304549; PMCID: PMC10832293.

367．Zhao M, Wang Y, Shen Y, Wei C, Zhang G, Sun L. A review of the roles of pathogens in Alzheimer's disease. Front Neurosci. 2024 Aug 19;18:1439055. doi: 10.3389/fnins.2024.1439055. PMID: 39224577; PMCID: PMC11366636.

368．Wang J, Wu Y, Chen Z, Chen Y, Lin Q, Liang Y. Exogenous Bioactive Peptides Have a Potential Therapeutic Role in Delaying Aging in Rodent Models. Int J Mol Sci. 2022 Jan 26;23(3):1421. doi: 10.3390/ijms23031421. PMID: 35163342; PMCID: PMC8835817.

369．Gao J, Zhou N, Lu M, Wang Q, Zhao C, Wang J, Zhou M, Xu Y. Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice. Front Microbiol. 2023 Jan 24;13:1047121. doi: 10.3389/fmicb.2022.1047121. PMID: 36762099; PMCID: PMC9904445.

370．Borsom EM, Conn K, Keefe CR, Herman C, Orsini GM, Hirsch AH, Palma Avila M, Testo G, Jaramillo SA, Bolyen E, Lee K, Caporaso JG, Cope EK. Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer's Disease Pathologies. Microbiol Spectr. 2023 Mar 6;11(2):e0345822. doi: 10.1128/spectrum.03458-22. Epub ahead of print. PMID: 36877047; PMCID: PMC10101110.

371．Alhazmi HA, Albratty M. An update on the novel and approved drugs for Alzheimer disease. Saudi Pharm J. 2022 Dec;30(12):1755-1764. doi: 10.1016/j.jsps.2022.10.004. Epub 2022 Oct 12. PMID: 36601504; PMCID: PMC9805975.

372．Kim HS, Kim S, Shin SJ, Park YH, Nam Y, Kim CW, Lee KW, Kim SM, Jung ID, Yang HD, Park YM, Moon M. Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications. Transl Neurodegener. 2021 Dec 7;10(1):49. doi: 10.1186/s40035-021-00273-y. PMID: 34876226; PMCID: PMC8650380.

373．Wu J, Wu M, Zhang H, Zhan X, Wu N. An Oligomannuronic Acid-Sialic Acid Conjugate Capable of Inhibiting Aβ42 Aggregation and Alleviating the Inflammatory Response of BV-2 Microglia. Int J Mol Sci. 2021 Nov 15;22(22):12338. doi: 10.3390/ijms222212338. PMID: 34830217; PMCID: PMC8621211.

374．Petrisko TJ, Gargus M, Chu SH, Selvan P, Whiteson KL, Tenner AJ. Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer's mouse models. J Neuroinflammation. 2023 Sep 19;20(1):211. doi: 10.1186/s12974-023-02885-9. PMID: 37726739; PMCID: PMC10507976.

375．Zhu L, Wang Y, Pan CQ, Xing H. Gut microbiota in alcohol-related liver disease: pathophysiology and gut-brain cross talk. Front Pharmacol. 2023 Aug 4;14:1258062. doi: 10.3389/fphar.2023.1258062. PMID: 37601074; PMCID: PMC10436520.

376．Zhou Z, Chen X, Sheng H, Shen X, Sun X, Yan Y, Wang J, Yuan Q. Engineering probiotics as living diagnostics and therapeutics for improving human health. Microb Cell Fact. 2020 Mar 4;19(1):56. doi: 10.1186/s12934-020-01318-z. PMID:32131831; PMCID: PMC7055047.

377．Bramble MS, Vashist N, Ko A, Priya S, Musasa C, Mathieu A, Spencer A, Lupamba Kasendue M, Mamona Dilufwasayo P, Karume K, Nsibu J, Manya H, Uy MNA, Colwell B, Boivin M, Mayambu JPB, Okitundu D, Droit A, Mumba Ngoyi D, Blekhman R, Tshala-Katumbay D, Vilain E. The gut microbiome in konzo. Nat Commun. 2021 Sep 10;12(1):5371. doi: 10.1038/s41467-021-25694-1. PMID: 34508085; PMCID:PMC8433213.

378．Xu Y, Liu X, Liu X, Chen D, Wang M, Jiang X, Xiong Z. The Roles of the Gut Microbiota and Chronic Low-Grade Inflammation in Older Adults With Frailty. Front Cell Infect Microbiol. 2021 Jul 1;11:675414. doi: 10.3389/fcimb.2021.675414. PMID: 34277468; PMCID: PMC8282182.

379．Gong HS, Pan JP, Guo F, Wu MM, Dong L, Li Y, Rong WF. Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice. Acta Pharmacol Sin. 2024 Sep;45(9):1821-1831. doi: 10.1038/s41401-024-01293-w. Epub 2024 May 3. PMID: 38702501; PMCID: PMC11335854.

380．Wang P, Cai Y, Zhong H, Chen R, Yi Y, Ye Y, Li L. Expression and Characterization of an Efficient Alginate Lyase from Psychromonas sp. SP041 through Metagenomics Analysis of Rotten Kelp. Genes (Basel). 2024 May 8;15(5):598. doi: 10.3390/genes15050598. PMID: 38790228; PMCID: PMC11121350.

381．Guo L, Li X, Gould T, Wang ZY, Cao W. T cell aging and Alzheimer's disease. Front Immunol. 2023 Apr 4;14:1154699. doi: 10.3389/fimmu.2023.1154699. PMID: 37081887; PMCID: PMC10110977.

382．Bian Y, Zhao C, Lee SM. Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside. Front Pharmacol. 2020 Oct 6;11:579052. doi: 10.3389/fphar.2020.579052. PMID: 33117172; PMCID: PMC7573929.

383．Zhang F, Qi N, Zeng Y, Bao M, Chen Y, Liao J, Wei L, Cao D, Huang S, Luo Q, Jiang Y, Mo Z. The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice. Front Microbiol. 2020 Oct 7;11:557342. doi: 10.3389/fmicb.2020.557342. PMID: 33117306; PMCID: PMC7575697.

384．Munir MU, Ali SA, Chung KHK, Kakinen A, Javed I, Davis TP. Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases. Gut Microbes. 2024 Jan-Dec;16(1):2422468. doi: 10.1080/19490976.2024.2422468. Epub 2024 Nov 10. PMID: 39523450; PMCID: PMC11556280.

385．Puranik N, Song M. Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target. Molecules. 2024 Dec 5;29(23):5744. doi: 10.3390/molecules29235744. PMID: 39683904; PMCID: PMC11643865.

386．Doenyas C. Potential Role of Epigenetics and Redox Signaling in the Gut- Brain Communication and the Case of Autism Spectrum Disorder. Cell Mol Neurobiol. 2022 Mar;42(2):483-487. doi: 10.1007/s10571-021-01167-3. Epub 2021 Nov 13. PMID: 34773541; PMCID: PMC11441204.

387．Lei K, Zhou L, Dan M, Yang F, Jian T, Xin J, Yu Z, Wang Y. Trojan Horse Delivery Strategies of Natural Medicine Monomers: Challenges and Limitations in Improving Brain Targeting. Pharmaceutics. 2025 Feb 20;17(3):280. doi: 10.3390/pharmaceutics17030280. PMID: 40142943; PMCID: PMC11945504.

388．Yang J, Liang J, Hu N, He N, Liu B, Liu G, Qin Y. The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings. CNS Neurosci Ther. 2024 Oct;30(10):e70091. doi: 10.1111/cns.70091. PMID: 39460538; PMCID: PMC11512114.

389．Su Y, Li X, Li D, Sun J. Fecal Microbiota Transplantation Shows Marked Shifts in the Multi-Omic Profiles of Porcine Post-weaning Diarrhea. Front Microbiol. 2021 Feb 23;12:619460. doi: 10.3389/fmicb.2021.619460. PMID: 33708182; PMCID: PMC7940351.

390．Yang S, Liu Z, Fu X, Zhu C, Kong Q, Yang M, Mou H. Expression and Characterization of an Alginate Lyase and Its Thermostable Mutant in Pichia pastoris. Mar Drugs. 2020 Jun 11;18(6):305. doi: 10.3390/md18060305. PMID: 32545157; PMCID: PMC7345639.

391．Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM. Alzheimer's disease. Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2. PMID: 33667416; PMCID: PMC8354300.

392．Wang C, Cai X, Wang R, Zhai S, Zhang Y, Hu W, Zhang Y, Wang D. Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice. J Neuroinflammation. 2020 Oct 18;17(1):309. doi: 10.1186/s12974-020-01976-1. PMID: 33070776; PMCID: PMC7570123.

393．Anderson C, Bucholc M, McClean PL, Zhang SD. The Potential of a Stratified Approach to Drug Repurposing in Alzheimer's Disease. Biomolecules. 2023 Dec 21;14(1):11. doi: 10.3390/biom14010011. PMID: 38275752; PMCID: PMC10813465.

394．Hayat K, Nixon G, Zhang Q, Matziari M. Symmetrical Phosphinic Acids: Synthesis and Esterification Optimization toward Potential HIV Prodrugs. ACS Omega. 2024 Sep 27;9(40):41742-41757. doi: 10.1021/acsomega.4c05988. PMID: 39398174; PMCID: PMC11465283.

395．Zhu F, Wang L, Gong Z, Wang Y, Gao Y, Cai W, Wu J. Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice. J Neuroinflammation. 2021 Mar 6;18(1):66. doi: 10.1186/s12974-021-02111-4. PMID: 33676524; PMCID: PMC7937302.

396．Zhu H, Wang W, Li Y. The interplay between microbiota and brain-gut axis in epilepsy treatment. Front Pharmacol. 2024 Jan 26;15:1276551. doi: 10.3389/fphar.2024.1276551. PMID: 38344171; PMCID: PMC10853364.

397．Zhang M, Liang C, Chen X, Cai Y, Cui L. Interplay between microglia and environmental risk factors in Alzheimer's disease. Neural Regen Res. 2024 Aug 1;19(8):1718-1727. doi: 10.4103/1673-5374.389745. Epub 2023 Dec 11. PMID: 38103237; PMCID: PMC10960290.

398．Seo DO, Holtzman DM. Current understanding of the Alzheimer's disease- associated microbiome and therapeutic strategies. Exp Mol Med. 2024 Feb;56(1):86-94. doi: 10.1038/s12276-023-01146-2. Epub 2024 Jan 4. PMID: 38172602; PMCID: PMC10834451.

399．Wasén C, Simonsen E, Ekwudo MN, Profant MR, Cox LM. The emerging role of the microbiome in Alzheimer's disease. Int Rev Neurobiol. 2022;167:101-139. doi: 10.1016/bs.irn.2022.09.001. Epub 2022 Oct 13. PMID: 36427953; PMCID: PMC10170863.

400．Su Y, Liu N, Sun R, Ma J, Li Z, Wang P, Ma H, Sun Y, Song J, Zhang Z. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3βsignaling pathway and intestinal microbiota. Front Pharmacol. 2023 Feb 8;14:1115387. doi: 10.3389/fphar.2023.1115387. PMID: 36843923; PMCID:PMC9945319.

401．Klose J, Griehl C, Roßner S, Schilling S. Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. Biomolecules. 2022 May 12;12(5):694. doi: 10.3390/biom12050694. PMID: 35625622; PMCID: PMC9139049.

402．Lu J, Pan Q, Zhou J, Weng Y, Chen K, Shi L, Zhu G, Chen C, Li L, Geng M, Zhang Z. Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China. J Pharm Anal. 2022 Feb;12(1):145-155. doi: 10.1016/j.jpha.2021.06.001. Epub 2021 Jun 5. PMID: 35573885; PMCID: PMC9073255.

403．Hettle AG, Vickers CJ, Boraston AB. Sulfatases: Critical Enzymes for Algal Polysaccharide Processing. Front Plant Sci. 2022 Apr 28;13:837636. doi: 10.3389/fpls.2022.837636. PMID: 35574087; PMCID: PMC9096561.

404．Wu J, Zhu Y, Zhou L, Lu Y, Feng T, Dai M, Liu J, Xu W, Cheng W, Sun F, Liu H, Pan W, Yang X. Parasite-Derived Excretory-Secretory Products Alleviate Gut Microbiota Dysbiosis and Improve Cognitive Impairment Induced by a High-Fat Diet. Front Immunol. 2021 Oct 20;12:710513. doi: 10.3389/fimmu.2021.710513. PMID: 34745091; PMCID: PMC8564115.

405．Liu MM, Zhou N, Jiang N, Lu KM, Wu CF, Bao JK. Neuroprotective Effects of Oligosaccharides From Periplaneta Americana on Parkinson's Disease ModelsIn Vitro and In Vivo. Front Pharmacol. 2022 Jul 18;13:936818. doi: 10.3389/fphar.2022.936818. PMID: 35924055; PMCID: PMC9340460.

406．Li J, Zou B, Cheng XY, Yang XH, Li J, Zhao CH, Ma RX, Tian JX, Yao Y. Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer's disease. Front Pharmacol. 2022 Jul 21;13:940999. doi: 10.3389/fphar.2022.940999. PMID: 35935875; PMCID: PMC9351603.

407．Fang X, Wu H, Wang X, Lian F, Li M, Miao R, Wei J, Tian J. Modulation of Gut Microbiota and Metabolites by Berberine in Treating Mice With Disturbances in Glucose and Lipid Metabolism. Front Pharmacol. 2022 Jun 3;13:870407. doi: 10.3389/fphar.2022.870407. PMID: 35721198; PMCID: PMC9204213.

408．Li X, Deng R, Li J, Li H, Xu Z, Zhang L, Feng L, Shu C, Zhen M, Wang C. Oral [60]fullerene reduces neuroinflammation to alleviate Parkinson's disease via regulating gut microbiome. Theranostics. 2023 Sep 4;13(14):4936-4951. doi: 10.7150/thno.85711. PMID: 37771782; PMCID: PMC10526674.

409．Li Y, Jiang H, Wang X, Liu X, Huang Y, Wang Z, Ma Q, Dong L, Qi Y, Zhang H, Lu G. Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors. Front Cell Infect Microbiol. 2022 Jun 17;12:881071. doi: 10.3389/fcimb.2022.881071. PMID: 35782130; PMCID: PMC9247299.

410．Yu CC, Du YJ, Li J, Li Y, Wang L, Kong LH, Zhang YW. Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update. Aging Dis. 2022 Jul 11;13(4):1092-1105. doi: 10.14336/AD.2021.1205. PMID: 35855345; PMCID:PMC9286922.

411．Sun Z, Zhang Y, Zhang M, Zhou S, Cheng W, Xue L, Zhou P, Li X, Zhang Z, Zuo L. Integrated brain and plasma dual-channel metabolomics to explore the treatment effects of Alpinia oxyphyllaFructus on Alzheimer's disease. PLoS One. 2023 Aug 8;18(8):e0285401. doi: 10.1371/journal.pone.0285401. PMID: 37552694; PMCID: PMC10409282.

412．Gong Y, Luo H, Li Z, Feng Y, Liu Z, Chang J. Metabolic Profile of Alzheimer's Disease: Is 10-Hydroxy-2-decenoic Acid a Pertinent Metabolic Adjuster? Metabolites. 2023 Aug 18;13(8):954. doi: 10.3390/metabo13080954. PMID:37623897; PMCID: PMC10456792.

413．Gao J, Zhou N, Wu Y, Lu M, Wang Q, Xia C, Zhou M, Xu Y. Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice. J Transl Med. 2021 Aug 16;19(1):351. doi: 10.1186/s12967-021-03032-9.PMID: 34399766; PMCID: PMC8365912.

414．Yang Y, Yu X, Liu X, Liu G, Zeng K, Wang G. Altered fecal microbiota composition in individuals who abuse methamphetamine. Sci Rep. 2021 Sep 13;11(1):18178. doi: 10.1038/s41598-021-97548-1. PMID: 34518605; PMCID: PMC8437956.

415．Li T, Yang S, Liu X, Li Y, Gu Z, Jiang Z. Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis. J Adv Res. 2023 Oct;52:119-134. doi: 10.1016/j.jare.2023.04.014. Epub 2023 Apr 20. PMID: 37085001; PMCID: PMC10555787.

416．Gan L, Xu WH, Xiong Y, Lv Z, Zheng J, Zhang Y, Lin J, Liu J, Chen S, Chen M, Guo Q, Wu J, Chen J, Su Z, Sun J, He Y, Liu C, Wang W, Verstraete W, Sorgeloos P, Defoirdt T, Qin Q, Liu Y. Probiotics: their action against pathogens can be turned around. Sci Rep. 2021 Jun 24;11(1):13247. doi: 10.1038/s41598-021-91542-3. PMID: 34168166; PMCID: PMC8225825.

417．Su Y, Wang D, Liu N, Yang J, Sun R, Zhang Z. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PLoS One. 2023 Jun 2;18(6):e0286086. doi: 10.1371/journal.pone.0286086. PMID: 37267300; PMCID:PMC10237464.

418．Lin X, Huang J, Wang S, Zhang K. Bipolar disorder and the gut microbiota: a bibliometric analysis. Front Neurosci. 2024 Mar 21;18:1290826. doi: 10.3389/fnins.2024.1290826. PMID: 38576868; PMCID: PMC10991819.

419．Yan L, Li H, Qian Y, Liu Q, Cong S, Dou B, Wang Y, Wang M, Yu T. Acupuncture modulates the gut microbiota in Alzheimer's disease: current evidence, challenges, and future opportunities. Front Neurosci. 2024 Mar 1;18:1334735. doi: 10.3389/fnins.2024.1334735. PMID: 38495110; PMCID: PMC10940355.

420．Li S, Chen H, Zhao R, Wang T, Ye J. Organic food consumption is positively associated with cognitive function among middle-aged and older adults: cross- sectional and longitudinal analyses. Eur J Nutr. 2024 Dec 2;64(1):40. doi: 10.1007/s00394-024-03555-z. PMID: 39621138.

421．Wu S, Yin Y, Du L. Blood-Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder. Cell Mol Neurobiol. 2022 Nov;42(8):2571-2591. doi: 10.1007/s10571-021-01153-9. Epub 2021 Oct 12. PMID: 34637015; PMCID: PMC11421634.

422．Dhanawat M, Malik G, Wilson K, Gupta S, Gupta N, Sardana S. The Gut Microbiota-Brain Axis: A New Frontier in Alzheimer's Disease Pathology. CNS Neurol Disord Drug Targets. 2025;24(1):7-20. doi: 10.2174/0118715273302508240613114103. PMID: 38967078.

423．Randeni N, Xu B. Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression. Int J Mol Sci. 2025 Jan 13;26(2):614. doi: 10.3390/ijms26020614. PMID: 39859327; PMCID: PMC11765984.

424．Zhang H, Wang Z, Yao H, Jiang L, Tong J. Intramammary infusion of matrine- chitosan hydrogels for treating subclinical bovine mastitis -effects on milk microbiome and metabolites. Front Microbiol. 2022 Sep 20;13:950231. doi: 10.3389/fmicb.2022.950231. PMID: 36204605; PMCID: PMC9530655.

425．Wang Z, Chen WH, Li SX, He ZM, Zhu WL, Ji YB, Wang Z, Zhu XM, Yuan K, Bao YP, Shi L, Meng SQ, Xue YX, Xie W, Shi J, Yan W, Wei H, Lu L, Han Y. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation. Mol Psychiatry. 2021 Nov;26(11):6277-6292. doi: 10.1038/s41380-021-01113-1. Epub 2021 May 7. PMID: 33963281.

426．Khan I, Khan I, Usman M, Jianye Z, Wei ZX, Ping X, Zhiqiang L, Lizhe A. Analysis of the blood bacterial composition of patients with acute coronary syndrome and chronic coronary syndrome. Front Cell Infect Microbiol. 2022 Oct 4;12:943808. doi: 10.3389/fcimb.2022.943808. PMID: 36268223; PMCID: PMC9577097.

427．Xiao S, Chan P, Wang T, Hong Z, Wang S, Kuang W, He J, Pan X, Zhou Y, Ji Y, Wang L, Cheng Y, Peng Y, Ye Q, Wang X, Wu Y, Qu Q, Chen S, Li S, Chen W, Xu J, Peng D, Zhao Z, Li Y, Zhang J, Du Y, Chen W, Fan D, Yan Y, Liu X, Zhang W, Luo B, Wu W, Shen L, Liu C, Mao P, Wang Q, Zhao Q, Guo Q, Zhou Y, Li Y, Jiang L, Ren W, Ouyang Y, Wang Y, Liu S, Jia J, Zhang N, Liu Z, He R, Feng T, Lu W, Tang H, Gao P, Zhang Y, Chen L, Wang L, Yin Y, Xu Q, Xiao J, Cong L, Cheng X, Zhang H, Gao D, Xia M, Lian T, Peng G, Zhang X, Jiao B, Hu H, Chen X, Guan Y, Cui R, Huang Q, Xin X, Chen H, Ding Y, Zhang J, Feng T, Cantillon M, Chen K, Cummings JL, Ding J, Geng M, Zhang Z. A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia. Alzheimers Res Ther. 2021 Mar 17;13(1):62. doi: 10.1186/s13195-021-00795-7. PMID: 33731209; PMCID:PMC7967962.

428．Martens N, Schepers M, Zhan N, Leijten F, Voortman G, Tiane A, Rombaut B, Poisquet J, Sande NV, Kerksiek A, Kuipers F, Jonker JW, Liu H, Lütjohann D, Vanmierlo T, Mulder MT. 24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease. Mar Drugs. 2021 Mar 27;19(4):190. doi: 10.3390/md19040190. PMID: 33801706; PMCID: PMC8065937.

429．Liu J, Ting JP, Al-Azzam S, Ding Y, Afshar S. Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases. Int J Mol Sci. 2021 Mar 10;22(6):2805. doi: 10.3390/ijms22062805. PMID: 33802091; PMCID: PMC8001105.

430．Ding X, Liu Z, Liu Y, Xu B, Chen J, Pu J, Wu D, Yu H, Jin C, Wang X. Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia-reperfusion injury based on integrating fecal metabonomics and 16S rDNA sequencing. Front Cell Infect Microbiol. 2022 Oct 27;12:1026627. doi: 10.3389/fcimb.2022.1026627. PMID: 36389137; PMCID: PMC9648199.

431．Fang J, Pieper AA, Nussinov R, Lee G, Bekris L, Leverenz JB, Cummings J, Cheng F. Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing. Med Res Rev. 2020 Nov;40(6):2386-2426. doi: 10.1002/med.21709. Epub 2020 Jul 13. PMID: 32656864; PMCID: PMC7561446.

432．Loh JS, Mak WQ, Tan LKS, Ng CX, Chan HH, Yeow SH, Foo JB, Ong YS, How CW, Khaw KY. Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal Transduct Target Ther. 2024 Feb 16;9(1):37. doi: 10.1038/s41392-024-01743-1. PMID: 38360862; PMCID: PMC10869798.

433．Park JC, Im SH. The gut-immune-brain axis in neurodevelopment and neurological disorders. Microbiome Res Rep. 2022 Aug 17;1(4):23. doi: 10.20517/mrr.2022.11. PMID: 38046904; PMCID: PMC10688819.

434．Yan M, Man S, Sun B, Ma L, Guo L, Huang L, Gao W. Gut liver brain axis in diseases: the implications for therapeutic interventions. Signal Transduct Target Ther. 2023 Dec 6;8(1):443. doi: 10.1038/s41392-023-01673-4. PMID: 38057297; PMCID: PMC10700720.

435．Gong CX, Dai CL, Liu F, Iqbal K. Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer's Disease. Front Aging Neurosci. 2022 Feb 9;14:837649. doi: 10.3389/fnagi.2022.837649. PMID: 35222001; PMCID: PMC8864545.

436．Zang X, Chen S, Zhu J, Ma J, Zhai Y. The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases. Front Aging Neurosci. 2022 Apr 25;14:872134. doi: 10.3389/fnagi.2022.872134. PMID: 35547626; PMCID: PMC9082639.

437．Wang J, Zhang Y, Lu Q, Xing D, Zhang R. Exploring Carbohydrates for Therapeutics: A Review on Future Directions. Front Pharmacol. 2021 Nov 16;12:756724. doi: 10.3389/fphar.2021.756724. PMID: 34867374; PMCID: PMC8634948.

438．Wang J, Zhu X, Li Y, Guo W, Li M. Jiedu-Yizhi Formula Alleviates Neuroinflammation in AD Rats by Modulating the Gut Microbiota. Evid Based Complement Alternat Med. 2022 Jul 31;2022:4023006. doi: 10.1155/2022/4023006. PMID: 35958910; PMCID: PMC9357688.

439．Uddin MS, Kabir MT, Jeandet P, Mathew B, Ashraf GM, Perveen A, Bin-Jumah MN, Mousa SA, Abdel-Daim MM. Novel Anti-Alzheimer's Therapeutic Molecules Targeting Amyloid Precursor Protein Processing. Oxid Med Cell Longev. 2020 Apr29;2020:7039138. doi: 10.1155/2020/7039138. PMID: 32411333; PMCID: PMC7206886.

440．Giannoni P, Claeysen S, Noe F, Marchi N. Peripheral Routes to Neurodegeneration: Passing Through the Blood-Brain Barrier. Front Aging Neurosci. 2020 Feb 4;12:3. doi: 10.3389/fnagi.2020.00003. PMID: 32116645; PMCID:PMC7010934.

441．Zhang T, Gao G, Kwok LY, Sun Z. Gut microbiome-targeted therapies for Alzheimer's disease. Gut Microbes. 2023 Dec;15(2):2271613. doi: 10.1080/19490976.2023.2271613. Epub 2023 Nov 7. PMID: 37934614; PMCID: PMC10631445.

442．Yu CC, Wang J, Ye SS, Gao S, Li J, Wang L, Jiang T, Wang XS, Li BC, Shu Q, Lu W, Du YJ, Kong LH. Preventive Electroacupuncture Ameliorates D-Galactose- Induced Alzheimer's Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3β/mTOR Signaling Pathway. Evid Based Complement Alternat Med. 2020 Apr 23;2020:1428752. doi: 10.1155/2020/1428752. PMID: 32382276; PMCID: PMC7195631.

443．Lopez-Ibañez J, Pazos F, Chagoyen M. MBROLE3: improved functional enrichment of chemical compounds for metabolomics data analysis. Nucleic Acids Res. 2023 Jul 5;51(W1):W305-W309. doi: 10.1093/nar/gkad405. PMID: 37178003; PMCID: PMC10320153.

444．Svobodova B, Pulkrabkova L, Panek D, Misiachna A, Kolcheva M, Andrys R, Handl J, Capek J, Nyvltova P, Rousar T, Prchal L, Hepnarova V, Hrabinova M, Muckova L, Tosnerova D, Karabanovich G, Finger V, Soukup O, Horak M, Korabecny J. Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease. Int J Mol Sci. 2023 May 23;24(11):9124. doi: 10.3390/ijms24119124. PMID: 37298087; PMCID: PMC10252614.

445．Huang J, Huang N, Mao Q, Shi J, Qiu Y. Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus. Front Aging Neurosci. 2023 Mar 16;15:1130253. doi: 10.3389/fnagi.2023.1130253. PMID: 37009462; PMCID: PMC10062602.

446．Zhang Y, Chen Y, Yuan S, Yu Q, Fu J, Chen L, Liu J, He Y. Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota-gut-brain axis. Exp Brain Res. 2023 Jun;241(6):1661-1673. doi: 10.1007/s00221-023-06632-7. Epub 2023 May 18. PMID:37199774.

447．Yu CC, Du YJ, Wang SQ, Liu LB, Shen F, Wang L, Lin YF, Kong LH. Experimental Evidence of the Benefits of Acupuncture for Alzheimer's Disease: An Updated Review. Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. PMID: 33408601; PMCID: PMC7779610.

448．Borsom EM, Lee K, Cope EK. Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer's Disease. Brain Sci. 2020 Nov 3;10(11):814. doi: 10.3390/brainsci10110814. PMID: 33153085; PMCID: PMC7693835.

449．Catanesi M, Caioni G, Castelli V, Benedetti E, d'Angelo M, Cimini A. Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders. Mar Drugs. 2021 Jan 8;19(1):24. doi: 10.3390/md19010024. PMID: 33430021; PMCID: PMC7827849.

450．Jimenez-García AM, Villarino M, Arias N. A systematic review and meta- analysis of basal microbiota and cognitive function in Alzheimer's disease: A potential target for treatment or a contributor to disease progression? Alzheimers Dement (Amst). 2024 Dec 27;16(4):e70057. doi: 10.1002/dad2.70057. PMID: 39734582; PMCID: PMC11672027.

451．Lee JY, Wong CY, Koh RY, Lim CL, Kok YY, Chye SM. Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review. Yale J Biol Med. 2024 Jun 28;97(2):205-224. doi: 10.59249/JNKB9714. PMID: 38947104; PMCID: PMC11202106.

452．Liang P, Wang Y, Liu J, Huang H, Li Y, Kang J, Li G, Wu H. Identification and Exploration of Immunity-Related Genes and Natural Products for Alzheimer's Disease Based on Bioinformatics, Molecular Docking, and Molecular Dynamics. Immun Inflamm Dis. 2025 Apr;13(4):e70166. doi: 10.1002/iid3.70166. PMID: 40192032; PMCID: PMC11973734.

453．Afsharnia A, Cai Y, Nauta A, Groeneveld A, Folkerts G, Wösten MMSM, Braber S. In Vivo Evidence on the Emerging Potential of Non-Digestible Oligosaccharides as Therapeutic Agents in Bacterial and Viral Infections. Nutrients. 2025 Mar 19;17(6):1068. doi: 10.3390/nu17061068. PMID: 40292455; PMCID: PMC11945282.

454．Jia C, Chai J, Zhang S, Sun Y, He L, Sang Z, Chen D, Zheng X. The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments. Mar Drugs. 2025 Feb 20;23(3):91. doi: 10.3390/md23030091. PMID: 40137277; PMCID: PMC11943648.

455．Xing H, Xue S, Qin R, et al. Recent advances in drug development of Alzheimer’s disease: a comprehensive review[J].Int J Mol Sci.2025;269*):3905.

456．Jia C, Chai J, Zhang S, et al. The advances of marine natural products in the treatment of Alzheimer’s disease: a study based on cell and animal experiments[J]. Mar Drugs. 2025;23(3):91.

457．Zhu Y, Xu H, Yu C, et al. Polymers for the treatment of Alzheimer’s disease[J]. Front Pharmacol.2025;16:1512941.

458．Duan X, Nie Y, Xie Y, et al. Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway[J]. Front Microbiol.2024;15:1421608.

459．Zhang J, Zhang Y, Wang J, et al. Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies[J]. Signal Transduction And Targeted Therapy.2024;9(1):211.

460．Adil NA, Omo-Erigbe C, Yadav H, et al. The oral-gut microbiome-brain axis in cognition. Microorganisms.2025;13(4):814.

461．Schaible P, Henschel J, Erny D. How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells. Journal of Neuroinflammation. 2025;22(1):60.

462．Costa M, Soares C, Silva A, et al. Optimization of Nanoencapsulation of codium tomentosum extract of its potential application in yogurt fortification.Mar Drugs.2025;23(4):147.

463．Xing H, Yue S, Qin R, et al. Recent advances in drug development of Alzheimer’s disease: a comprehensive review[J]. Int J Mol Sci.2025;26(8):3905.

464．Wang C, Wu C, Song L. TRPA1-1 activated peptides for saiga antelope horn: screening, interaction mechanism and bioactivity. Int J Mol Sci.2025;26(5):2119.

465．Wang T, Kuang W, Chen W, Xu W, Zhang L, Li Y, Li H, Peng Y, Chen Y, Wang B,Xiao J, Li H, Yan C, Du Y, Tang M, He Z, Chen H, Li W, Lin H, Shi S, Bi J, Zhou H, Cheng Y, Gao X, Guan Y, Huang Q, Chen K, Xin X, Ding J, Geng M, Xiao S. A phase II randomized trial of sodium oligomannate in Alzheimer's dementia. Alzheimers Res Ther. 2020 Sep 14;12(1):110. doi: 10.1186/s13195-020-00678-3. PMID: 32928279; PMCID: PMC7489025.

466．Austad SN, Ballinger S, Buford TW, Carter CS, Smith DL Jr, Darley-Usmar V, Zhang J. Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease. Acta Pharm Sin B. 2022 Feb;12(2):511-531. doi: 10.1016/j.apsb.2021.06.014. Epub 2021 Jun 30. PMID: 35256932; PMCID: PMC8897048.

467．Md S, Alhakamy NA, Alfaleh MA, Afzal O, Altamimi ASA, Iqubal A, Shaik RA.Mechanisms Involved in Microglial-Interceded Alzheimer's Disease and Nanocarrier-Based Treatment Approaches. J Pers Med. 2021 Oct 29;11(11):1116. doi: 10.3390/jpm11111116. PMID: 34834468; PMCID: PMC8619529.

468．Liu X, Liu Y, Liu J, Zhang H, Shan C, Guo Y, Gong X, Cui M, Li X, Tang M. Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence. Neural Regen Res. 2024 Apr;19(4):833-845. doi: 10.4103/1673-5374.382223. PMID: 37843219; PMCID: PMC10664138.

469．Lu J, Pan Q, Zhou J, Weng Y, Chen K, Shi L, Zhu G, Chen C, Li L, Geng M, Zhang Z. Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China. J Pharm Anal. 2022 Feb;12(1):145-155. doi: 10.1016/j.jpha.2021.06.001. Epub 2021 Jun 5. PMID: 35573885; PMCID: PMC9073255.

470．Song M, Fan X. Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer's Disease: Finding Potential Therapeutic Targets. Int J Mol Sci. 2023 May 7;24(9):8398. doi: 10.3390/ijms24098398. PMID: 37176104; PMCID: PMC10179273.

471．Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024 Aug 23;9(1):211. doi: 10.1038/s41392-024-01911-3. PMID: 39174535; PMCID: PMC11344989.

472．Hao C, Han M, Wang W, Yang C, Wang J, Guo Y, Xu T, Zhang L, Li C. The neuroprotective effects of peracetylated chitosan oligosaccharides against β-amyloid-induced cognitive deficits in rats. Mar Life Sci Technol. 2023 May 22;5(2):211-222. doi: 10.1007/s42995-023-00172-3. PMID: 37275539; PMCID: PMC10232394.

473．Anderson C, Bucholc M, McClean PL, Zhang SD. The Potential of a Stratified Approach to Drug Repurposing in Alzheimer's Disease. Biomolecules. 2023 Dec 21;14(1):11. doi: 10.3390/biom14010011. PMID: 38275752; PMCID: PMC10813465.

474．Zhan Y, Al-Nusaif M, Ding C, Zhao L, Dong C. The potential of the gut microbiome for identifying Alzheimer's disease diagnostic biomarkers and future therapies. Front Neurosci. 2023 Apr 27;17:1130730. doi: 10.3389/fnins.2023.1130730. PMID: 37179559; PMCID: PMC10174259.

475．Ren R, Qi J, Lin S, Liu X, Yin P, Wang Z, Tang R, Wang J, Huang Q, Li J, Xie X, Hu Y, Cui S, Zhu Y, Yu X, Wang P, Zhu Y, Wang Y, Huang Y, Hu Y, Wang Y, Li C,Zhou M, Wang G. The China Alzheimer Report 2022. Gen Psychiatr. 2022 Mar 11;35(1):e100751. doi: 10.1136/gpsych-2022-100751. PMID: 35372787; PMCID: PMC8919463.

476．Decourt B, Noorda K, Noorda K, Shi J, Sabbagh MN. Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia. J Exp Pharmacol. 2022 Oct 30;14:331-352. doi: 10.2147/JEP.S265626. PMID: 36339394; PMCID: PMC9632331.

477．Martins B, Vieira M, Delerue-Matos C, Grosso C, Soares C. Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae- Derived Compounds with Neuroprotective Activity: A Comprehensive Review. Mar Drugs. 2022 May 28;20(6):362. doi: 10.3390/md20060362. PMID: 35736165; PMCID:PMC9227170.

478．Chen Y, Lai M, Tao M. Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review. Medicine (Baltimore). 2024 Apr 19;103(16):e37799. doi: 10.1097/MD.0000000000037799. PMID: 38640313; PMCID:PMC11029996.

479．Mumtaz I, Ayaz MO, Khan MS, Manzoor U, Ganayee MA, Bhat AQ, Dar GH, Alghamdi BS, Hashem AM, Dar MJ, Ashraf GM, Maqbool T. Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer's disease. Front Aging Neurosci. 2022 Sep 7;14:977411.doi: 10.3389/fnagi.2022.977411. PMID: 36158539; PMCID: PMC9490081.

480．Yang X, Zhangyi Z, Yu A, Zhou Q, Xia A, Qiu J, Cai M, Chu X, Li L, Feng Z, Luo Z, Sun G, Zhang J, Geng M, Chen S, Xie Z. GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities. CNS Neurosci Ther. 2024 Jul;30(7):e14847. doi: 10.1111/cns.14847. PMID: 38973196; PMCID: PMC11228355.

481．Xie X, Song Q, Dai C, Cui S, Tang R, Li S, Chang J, Li P, Wang J, Li J, Gao C, Chen H, Chen S, Ren R, Gao X, Wang G. Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer's disease: a phase I/II clinical trial. Gen Psychiatr. 2023 Oct 11;36(5):e101143. doi: 10.1136/gpsych-2023-101143. PMID: 37859748; PMCID: PMC10582850.

482．Zhang Y, Zhang M. Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease. Front Aging Neurosci. 2022 Sep 8;14:963041. doi: 10.3389/fnagi.2022.963041. PMID: 36158563; PMCID: PMC9493036.

483．Jannat K, Balakrishnan R, Han JH, Yu YJ, Kim GW, Choi DK. The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source. Cells. 2023 Nov 18;12(22):2652. doi: 10.3390/cells12222652. PMID: 37998387; PMCID: PMC10670678.

484．Guo Y, Xu Y, Lin X, Zhen Z, Yi F, Guan H, Shi Q, Sun W, Yang A, Dong X, Wang J. Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota. Front Neurol. 2022 Apr 15;13:832599. doi: 10.3389/fneur.2022.832599. PMID: 35493823; PMCID: PMC9051076.

485．Liu W, He K, Wu D, Zhou L, Li G, Lin Z, Yang X, Liu J, Pui Man Hoi M. Natural Dietary Compound Xanthohumol Regulates the Gut Microbiota and Its Metabolic Profile in a Mouse Model of Alzheimer's Disease. Molecules. 2022 Feb 14;27(4):1281. doi: 10.3390/molecules27041281. PMID: 35209070; PMCID: PMC8880053.

486．Xie J, Zhong C, Wang T, He D, Lu L, Yang J, Yuan Z, Zhang J. Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version. Front Pharmacol. 2022 Jun 27;13:937075. doi: 10.3389/fphar.2022.937075. PMID: 35833035; PMCID: PMC9271619.

487．Saiyasit N, Butlig ER, Chaney SD, Traylor MK, Hawley NA, Randall RB, Bobinger HV, Frizell CA, Trimm F, Crook ED, Lin M, Hill BD, Keller JL, Nelson AR. Neurovascular Dysfunction in Diverse Communities With Health Disparities-Contributions to Dementia and Alzheimer's Disease. Front Neurosci. 2022 Jun 29;16:915405. doi: 10.3389/fnins.2022.915405. PMID: 35844216; PMCID: PMC9279126.

488．Li R, Miao Z, Liu Y, Chen X, Wang H, Su J, Chen J. The Brain-Gut-Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects. Adv Sci (Weinh). 2024 Oct;11(38):e2307971. doi: 10.1002/advs.202307971. Epub 2024 Aug 9. PMID: 39120490; PMCID: PMC11481201.

489．Abitbol A, Mallard B, Tiralongo E, Tiralongo J. Mushroom Natural Products in Neurodegenerative Disease Drug Discovery. Cells. 2022 Dec 6;11(23):3938. doi: 10.3390/cells11233938. PMID: 36497196; PMCID: PMC9740391.

490．Athar T, Al Balushi K, Khan SA. Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease. Mol Biol Rep. 2021 Jul;48(7):5629-5645. doi: 10.1007/s11033-021-06512-9. Epub 2021 Jun 28. PMID: 34181171; PMCID: PMC8236749.

491．Yu TW, Lane HY, Lin CH. Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review. Int J Mol Sci. 2021 Jul 30;22(15):8208. doi: 10.3390/ijms22158208. PMID: 34360973; PMCID: PMC8348485.

492．Puranik N, Song M. Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target. Molecules. 2024 Dec 5;29(23):5744. doi: 10.3390/molecules29235744. PMID: 39683904; PMCID: PMC11643865.

493．Xiao S, Chan P, Wang T, Hong Z, Wang S, Kuang W, He J, Pan X, Zhou Y, Ji Y, Wang L, Cheng Y, Peng Y, Ye Q, Wang X, Wu Y, Qu Q, Chen S, Li S, Chen W, Xu J, Peng D, Zhao Z, Li Y, Zhang J, Du Y, Chen W, Fan D, Yan Y, Liu X, Zhang W, Luo B, Wu W, Shen L, Liu C, Mao P, Wang Q, Zhao Q, Guo Q, Zhou Y, Li Y, Jiang L, Ren W, Ouyang Y, Wang Y, Liu S, Jia J, Zhang N, Liu Z, He R, Feng T, Lu W, Tang H, Gao P, Zhang Y, Chen L, Wang L, Yin Y, Xu Q, Xiao J, Cong L, Cheng X, Zhang H, Gao D, Xia M, Lian T, Peng G, Zhang X, Jiao B, Hu H, Chen X, Guan Y, Cui R, Huang Q, Xin X, Chen H, Ding Y, Zhang J, Feng T, Cantillon M, Chen K, Cummings JL, Ding J, Geng M, Zhang Z. A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia. Alzheimers Res Ther. 2021 Mar 17;13(1):62. doi: 10.1186/s13195-021-00795-7. PMID: 33731209; PMCID: PMC7967962.

494．Ferreiro AL, Choi J, Ryou J, Newcomer EP, Thompson R, Bollinger RM, Hall-Moore C, Ndao IM, Sax L, Benzinger TLS, Stark SL, Holtzman DM, Fagan AM, Schindler SE, Cruchaga C, Butt OH, Morris JC, Tarr PI, Ances BM, Dantas G. Gut microbiome composition may be an indicator of preclinical Alzheimer's disease. Sci Transl Med. 2023 Jun 14;15(700):eabo2984. doi: 10.1126/scitranslmed.abo2984. Epub 2023 Jun 14. PMID: 37315112; PMCID: PMC10680783.

495．Lee JY, Wong CY, Koh RY, Lim CL, Kok YY, Chye SM. Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review. Yale J Biol Med. 2024 Jun 28;97(2):205-224. doi: 10.59249/JNKB9714. PMID: 38947104; PMCID: PMC11202106.

496．Scassellati C, Galoforo AC, Esposito C, Ciani M, Ricevuti G, Bonvicini C. Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer's Disease and Its Neuropsychiatric Symptoms. Aging Dis. 2021 Aug 1;12(5):1337-1357. doi: 10.14336/AD.2021.0122. PMID: 34341712; PMCID: PMC8279527.

497．Pleen J, Townley R. Alzheimer's disease clinical trial update 2019-2021. J Neurol. 2022 Feb;269(2):1038-1051. doi: 10.1007/s00415-021-10790-5. Epub 2021 Oct 5. PMID: 34609602.

498．Zhu Y, Xu H, Yu C, Jiang W, Hou X, Ma M, Wu J. Polymers for the treatment of Alzheimer's disease. Front Pharmacol. 2025 Jan 29;16:1512941. doi: 10.3389/fphar.2025.1512941. PMID: 39944627; PMCID: PMC11813879.

499．Alfei S, Zuccari G. Ellagic Acid: A Green Multi-Target Weapon That Reduces Oxidative Stress and Inflammation to Prevent and Improve the Condition of Alzheimer's Disease. Int J Mol Sci. 2025 Jan 20;26(2):844. doi: 10.3390/ijms26020844. PMID: 39859559; PMCID: PMC11766176.

500．Yang Y, Qiu L. Research Progress on the Pathogenesis, Diagnosis, and Drug Therapy of Alzheimer's Disease. Brain Sci. 2024 Jun 9;14(6):590. doi: 10.3390/brainsci14060590. PMID: 38928590; PMCID: PMC11201671.

501．Zhang M, Liang C, Chen X, Cai Y, Cui L. Interplay between microglia and environmental risk factors in Alzheimer's disease. Neural Regen Res. 2024 Aug 1;19(8):1718-1727. doi: 10.4103/1673-5374.389745. Epub 2023 Dec 11. PMID: 38103237; PMCID: PMC10960290.

502．Helgudóttir SS, Mørkholt AS, Lichota J, Bruun-Nyzell P, Andersen MC, Kristensen NMJ, Johansen AK, Zinn MR, Jensdóttir HM, Nieland JDV. Rethinking neurodegenerative diseases: neurometabolic concept linking lipid oxidation to diseases in the central nervous system. Neural Regen Res. 2024 Jul 1;19(7):1437-1445. doi: 10.4103/1673-5374.387965. Epub 2023 Nov 8. PMID: 38051885; PMCID: PMC10883494.

503．Chandra S, Sisodia SS, Vassar RJ. The gut microbiome in Alzheimer's disease: what we know and what remains to be explored. Mol Neurodegener. 2023 Feb 1;18(1):9. doi: 10.1186/s13024-023-00595-7. PMID: 36721148; PMCID:  PMC9889249.

504．Lu J, Pan Q, Zhou J, Weng Y, Chen K, Shi L, Zhu G, Chen C, Li L, Geng M, Zhang Z. Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China. J Pharm Anal. 2022 Feb;12(1):145-155. doi: 10.1016/j.jpha.2021.06.001. Epub 2021 Jun 5. PMID: 35573885; PMCID: PMC9073255.

505．Chen Y, Yu Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. J Neuroinflammation. 2023 Jul 14;20(1):165. doi: 10.1186/s12974-023-02853-3. PMID: 37452321; PMCID: PMC10349496.

506．Zhu L, Wang Y, Wu Y, Wilson A, Zhou H, Li N, Wang Y. Longitudinal associations between the frequency of playing Mahjong and cognitive functioning among older people in China: evidence from CLHLS, 2008-2018. Front Public Health. 2024 Mar 14;12:1352433. doi: 10.3389/fpubh.2024.1352433. PMID: 38550318; PMCID: PMC10973127.

507．Jannat K, Balakrishnan R, Han JH, Yu YJ, Kim GW, Choi DK. The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source. Cells. 2023 Nov 18;12(22):2652. doi: 10.3390/cells12222652. PMID: 37998387; PMCID: PMC10670678.

508．Gates EJ, Bernath AK, Klegeris A. Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases. Rev Neurosci. 2022 Mar 21;33(7):767-787. doi: 10.1515/revneuro-2021-0146. PMID: 35304983; PMCID: PMC9514114.

509．Xie X, Song Q, Dai C, Cui S, Tang R, Li S, Chang J, Li P, Wang J, Li J, Gao C, Chen H, Chen S, Ren R, Gao X, Wang G. Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer's disease: a phase I/II clinical trial. Gen Psychiatr. 2023 Oct 11;36(5):e101143. doi: 10.1136/gpsych-2023-101143. PMID: 37859748; PMCID: PMC10582850.

510．Zhang Y, Wu KM, Yang L, Dong Q, Yu JT. Tauopathies: new perspectives and challenges. Mol Neurodegener. 2022 Apr 7;17(1):28. doi: 10.1186/s13024-022-00533-z. PMID: 35392986; PMCID: PMC8991707.

511．Sahlgren Bendtsen KM, Hall VJ. The Breakthroughs and Caveats of Using Human Pluripotent Stem Cells in Modeling Alzheimer's Disease. Cells. 2023 Jan 27;12(3):420. doi: 10.3390/cells12030420. PMID: 36766763; PMCID: PMC9913971.

512．Li ZH, Jiang YY, Long CY, Peng Q, Yue RS. The gut microbiota-astrocyte axis: Implications for type 2 diabetic cognitive dysfunction. CNS Neurosci Ther. 2023 Jun;29 Suppl 1(Suppl 1):59-73. doi: 10.1111/cns.14077. Epub 2023 Jan 4. PMID: 36601656; PMCID: PMC10314112.

513．Thangwaritorn S, Lee C, Metchikoff E, Razdan V, Ghafary S, Rivera D, Pinto A, Pemminati S. A Review of Recent Advances in the Management of Alzheimer's Disease. Cureus. 2024 Apr 16;16(4):e58416. doi: 10.7759/cureus.58416. PMID: 38756263; PMCID: PMC11098549.

514．Xu J, Liu B, Feng Z, Yu X, Shang G, Liu Y, Sun Y, Yang H, Chen Y, Zhang Y, Mao Z. Deep brain stimulation versus nonsurgical treatment for severe Alzheimer's disease: A long-term retrospective cohort study. J Alzheimers Dis Rep. 2024 Dec 23;8(1):1677-1689. doi: 10.1177/25424823241297852. PMID: 40034349; PMCID: PMC11863731.

515．Nie T, You L, Tang F, Duan Y, Nepovimova E, Kuca K, Wu Q, Wei W. Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases. Curr Neuropharmacol. 2025;23(5):524-546. doi: 10.2174/1570159X23666241101093436. PMID: 39501955.

516．Giovannini MG, Lana D, Traini C, Vannucchi MG. The Microbiota-Gut-Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells. J Clin Med. 2021 May 27;10(11):2358. doi: 10.3390/jcm10112358. PMID: 34072107; PMCID: PMC8199461.

517．Huang J, Huang N, Cui D, Shi J, Qiu Y. Clinical antidiabetic medication used in Alzheimer's disease: From basic discovery to therapeutics development. Front Aging Neurosci. 2023 Feb 10;15:1122300. doi: 10.3389/fnagi.2023.1122300. PMID: 36845652; PMCID: PMC9950577.

518．Morató X, Pytel V, Jofresa S, Ruiz A, Boada M. Symptomatic and Disease- Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach. Int J Mol Sci. 2022 Aug 18;23(16):9305. doi: 10.3390/ijms23169305. PMID: 36012569; PMCID: PMC9409252.

519．Huang LK, Kuan YC, Lin HW, Hu CJ. Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update. J Biomed Sci. 2023 Oct 2;30(1):83. doi: 10.1186/s12929-023-00976-6. PMID: 37784171; PMCID: PMC10544555.

520．Bang C, Heinzel S. Zusammenhänge zwischen Mikrobiom und  Neurodegeneration [Relationships between microbiome and neurodegeneration]. Nervenarzt. 2023 Oct;94(10):885-891. German. doi: 10.1007/s00115-023-01537-w. Epub 2023 Sep 6. PMID: 37672084.

521．Song M, Fan X. Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer's Disease: Finding Potential Therapeutic Targets. Int J Mol Sci. 2023 May 7;24(9):8398. doi: 10.3390/ijms24098398. PMID: 37176104; PMCID: PMC10179273.

522．Austad SN, Ballinger S, Buford TW, Carter CS, Smith DL Jr, Darley-Usmar V, Zhang J. Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease. Acta Pharm Sin B. 2022 Feb;12(2):511-531. doi: 10.1016/j.apsb.2021.06.014. Epub 2021 Jun 30. PMID: 35256932; PMCID: PMC8897048.

523．Zhou G, Yin Y, Huan X, Zhuang Y, Xu S, Liu J, Liu S, Duan J. The Potential Role of the Brain-gut Axis in the Development and Progression of Alzheimer's Disease. J Transl Int Med. 2022 Jul 2;10(2):89-91. doi: 10.2478/jtim-2022-0016. PMID: 35959446; PMCID: PMC9328030.

524．Zeng H, Zhou K, Zhuang Y, Li A, Luo B, Zhang Y. Unraveling the connection between gut microbiota and Alzheimer's disease: a two-sample Mendelian randomization analysis. Front Aging Neurosci. 2023 Oct 16;15:1273104. doi: 10.3389/fnagi.2023.1273104. PMID: 37908561; PMCID: PMC10613649.

525．Jalali D, Guevarra JA, Martinez L, Hung L, Vonhoff FJ. Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer's Disease. Int J Mol Sci. 2021 Jun 29;22(13):7022. doi: 10.3390/ijms22137022. PMID: 34209883; PMCID: PMC8269328.

526．Liang P, Wang Y, Liu J, Huang H, Li Y, Kang J, Li G, Wu H. Identification and Exploration of Immunity-Related Genes and Natural Products for Alzheimer's Disease Based on Bioinformatics, Molecular Docking, and Molecular Dynamics. Immun Inflamm Dis. 2025 Apr;13(4):e70166. doi: 10.1002/iid3.70166. PMID: 40192032; PMCID: PMC11973734.

527．Dhanawat M, Malik G, Wilson K, Gupta S, Gupta N, Sardana S. The Gut Microbiota-Brain Axis: A New Frontier in Alzheimer's Disease Pathology. CNS Neurol Disord Drug Targets. 2025;24(1):7-20. doi: 10.2174/0118715273302508240613114103. PMID: 38967078.

528．Yan M, Man S, Sun B, Ma L, Guo L, Huang L, Gao W. Gut liver brain axis in diseases: the implications for therapeutic interventions. Signal Transduct Target Ther. 2023 Dec 6;8(1):443. doi: 10.1038/s41392-023-01673-4. PMID: 38057297; PMCID: PMC10700720.

529．Saiyasit N, Butlig ER, Chaney SD, Traylor MK, Hawley NA, Randall RB, Bobinger HV, Frizell CA, Trimm F, Crook ED, Lin M, Hill BD, Keller JL, Nelson AR. Neurovascular Dysfunction in Diverse Communities With Health Disparities- Contributions to Dementia and Alzheimer's Disease. Front Neurosci. 2022 Jun 29;16:915405. doi: 10.3389/fnins.2022.915405. PMID: 35844216; PMCID: PMC9279126.

530．Pan Z, Wu N, Jin C. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients. Can J Infect Dis Med Microbiol. 2023 Oct 28;2023:3080969. doi: 10.1155/2023/3080969. PMID: 37927531; PMCID: PMC10625490.

531．Chen Y, Lai M, Tao M. Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review. Medicine (Baltimore). 2024 Apr 19;103(16):e37799. doi: 10.1097/MD.0000000000037799. PMID: 38640313; PMCID: PMC11029996.

532．Zhan Y, Al-Nusaif M, Ding C, Zhao L, Dong C. The potential of the gut microbiome for identifying Alzheimer's disease diagnostic biomarkers and future therapies. Front Neurosci. 2023 Apr 27;17:1130730. doi: 10.3389/fnins.2023.1130730. PMID: 37179559; PMCID: PMC10174259.

533．Guo X, Gao L, Liu J, Lu W, Wang J, Qu Q. Public acceptability of lumbar puncture in the diagnosis of Alzheimer's disease: a questionnaire-based single center study in China. Am J Transl Res. 2023 Jun 15;15(6):4179-4187. PMID: 37434808; PMCID: PMC10331662.

534．Cao Y, Yu F, Lyu Y, Lu X. Promising candidates from drug clinical trials: Implications for clinical treatment of Alzheimer's disease in China. Front Neurol. 2022 Nov 15;13:1034243. doi: 10.3389/fneur.2022.1034243. PMID: 36457865; PMCID: PMC9706102.

535．Yang X, Zhangyi Z, Yu A, Zhou Q, Xia A, Qiu J, Cai M, Chu X, Li L, Feng Z, Luo Z, Sun G, Zhang J, Geng M, Chen S, Xie Z. GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities. CNS Neurosci Ther. 2024 Jul;30(7):e14847. doi: 10.1111/cns.14847. PMID: 38973196; PMCID: PMC11228355.

536．Yu TW, Lane HY, Lin CH. Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review. Int J Mol Sci. 2021 Jul 30;22(15):8208. doi: 10.3390/ijms22158208. PMID: 34360973; PMCID: PMC8348485.

537．Jiang J, Shi H, Jiang S, Wang A, Zou X, Wang Y, Li W, Zhang Y, Sun M, Ren Q, Xu J. Nutrition in Alzheimer's disease: a review of an underappreciated pathophysiological mechanism. Sci China Life Sci. 2023 Oct;66(10):2257-2279. doi: 10.1007/s11427-022-2276-6. Epub 2023 Apr 7. PMID: 37058185.

538．Wang YL, Zhang Y, Xu J. Sodium oligomannate combined with rivastigmine may improve cerebral blood flow and cognitive impairment following CAR-T cell therapy: A case report. Front Oncol. 2022 Aug 18;12:902301. doi: 10.3389/fonc.2022.902301. PMID: 36059691; PMCID: PMC9433646.

539．Wasén C, Simonsen E, Ekwudo MN, Profant MR, Cox LM. The emerging role of the microbiome in Alzheimer's disease. Int Rev Neurobiol. 2022;167:101-139. doi: 10.1016/bs.irn.2022.09.001. Epub 2022 Oct 13. PMID: 36427953; PMCID: PMC10170863.

540．Asif M, Saleem M, Yaseen HS, Yehya AH, Saadullah M, Zubair HM, Oon CE, Khaniabadi PM, Khalid SH, Khan IU, Mahrukh. Potential role of marine species- derived bioactive agents in the management of SARS-CoV-2 infection. Future Microbiol. 2021 Nov;16(16):1289-1301. doi: 10.2217/fmb-2021-0024. Epub 2021 Oct 25. PMID: 34689597; PMCID: PMC8592065.

541．Itzhaki RF. Overwhelming Evidence for a Major Role for Herpes Simplex Virus Type 1 (HSV1) in Alzheimer's Disease (AD); Underwhelming Evidence against. Vaccines (Basel). 2021 Jun 21;9(6):679. doi: 10.3390/vaccines9060679. PMID: 34205498; PMCID: PMC8234998.

542．Xu J, Liu B, Shang G, Liu S, Feng Z, Yang H, Liu D, Chang Q, Chen Y, Yu X, Mao Z. Deep brain stimulation of the nucleus basalis of Meynert in severe Alzheimer's disease. J Alzheimers Dis Rep. 2024 Nov 24;8(1):1573-1586. doi: 10.1177/25424823241296780. PMID: 40034361; PMCID: PMC11863734.

543．Liu E, Zhang Y, Wang JZ. Updates in Alzheimer's disease: from basic research to diagnosis and therapies. Transl Neurodegener. 2024 Sep 4;13(1):45. doi: 10.1186/s40035-024-00432-x. PMID: 39232848; PMCID: PMC11373277.

544．Cao X, Du X, Jiao H, An Q, Chen R, Fang P, Wang J, Yu B.  Carbohydrate-based drugs launched during 2000-2021. Acta Pharm Sin B. 2022 Oct;12(10):3783-3821. doi: 10.1016/j.apsb.2022.05.020. Epub 2022 May 23. PMID: 36213536; PMCID: PMC9532563.

545．Klose J, Griehl C, Roßner S, Schilling S. Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. Biomolecules. 2022 May 12;12(5):694. doi: 10.3390/biom12050694. PMID: 35625622; PMCID:  PMC9139049.

546．Xing H, Yue S, Qin R, Du X, Wu Y, Zhangsun D, Luo S. Recent Advances in Drug Development for Alzheimer's Disease: A Comprehensive Review. Int J Mol Sci. 2025 Apr 21;26(8):3905. doi: 10.3390/ijms26083905. PMID: 40332804; PMCID: PMC12028297.

547．Jia C, Chai J, Zhang S, Sun Y, He L, Sang Z, Chen D, Zheng X. The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments. Mar Drugs. 2025 Feb 20;23(3):91. doi: 10.3390/md23030091. PMID: 40137277; PMCID: PMC11943648.

548．Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17;19(1):18. doi: 10.1186/s13024-023-00700-w. Erratum in: Mol Neurodegener. 2024 Oct 10;19(1):70. doi: 10.1186/s13024-024-00764-2. PMID: 38365827; PMCID: PMC10874048.

549．Gao M, Duan X, Liu XR, Luo S, Tang S, Nie H, Yan J, Zou Z, Chen C, Yin Q, Qiu J. Modulatory Effects of Huoxiang Zhengqi Oral Liquid on Gut Microbiome Homeostasis Based on Healthy Adults and Antibiotic-Induced Gut Microbial Dysbiosis Mice Model. Front Pharmacol. 2022 Mar 24;13:841990. doi: 10.3389/fphar.2022.841990. PMID: 35401199; PMCID: PMC8987308.

550．Conti Filho CE, Loss LB, Marcolongo-Pereira C, Rossoni Junior JV, Barcelos RM, Chiarelli-Neto O, da Silva BS, Passamani Ambrosio R, Castro FCAQ, Teixeira SF, Mezzomo NJ. Advances in Alzheimer's disease's pharmacological treatment. Front Pharmacol. 2023 Jan 26;14:1101452. doi: 10.3389/fphar.2023.1101452. PMID: 36817126; PMCID: PMC9933512.

551．Hu D, Jin Y, Hou X, Zhu Y, Chen D, Tai J, Chen Q, Shi C, Ye J, Wu M, Zhang H, Lu Y. Application of Marine Natural Products against Alzheimer's Disease: Past, Present and Future. Mar Drugs. 2023 Jan 5;21(1):43. doi: 10.3390/md21010043. PMID: 36662216; PMCID: PMC9867307.

552．Tikhonova MA, Chang HM, Singh SK, Vieau D. Editorial: Experimental and Innovative Approaches to Multi-Target Treatment of Parkinson's and Alzheimer's Diseases. Front Neurosci. 2022 May 16;16:910020. doi: 10.3389/fnins.2022.910020. PMID: 35651630; PMCID: PMC9150500.

553．Antar A, Szallasi A, Imataki O. Editorial: Case reports in hematological malignancies: 2022. Front Oncol. 2023 Aug 21;13:1272547. doi: 10.3389/fonc.2023.1272547. PMID: 37671065; PMCID: PMC10476086.

554．Wang J, Huang L, Wei L, Chen W. Factors affecting the efficacy of repetitive transcranial magnetic stimulation for patients with Alzheimer's disease. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2021 Jun 25;50(3):383-389. English. doi: 10.3724/zdxbyxb-2021-0184. PMID: 34402259; PMCID: PMC8710284.

555．Catumbela CSG, Giridharan VV, Barichello T, Morales R. Clinical evidence of human pathogens implicated in Alzheimer's disease pathology and the therapeutic efficacy of antimicrobials: an overview. Transl Neurodegener. 2023 Jul 26;12(1):37. doi: 10.1186/s40035-023-00369-7. PMID: 37496074; PMCID: PMC10369764.

556．Pan L, Xie L, Yang W, Feng S, Mao W, Ye L, Cheng H, Wu X, Mao X. The role of brain-liver-gut Axis in neurological disorders. Burns Trauma. 2025 May 2;13:tkaf011. doi: 10.1093/burnst/tkaf011. PMID: 40321299; PMCID:  PMC12048006.

557．Niazi SK. Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs-Protocols and Advice for the FDA to Meet the ALS Act Vision. Int J Mol Sci. 2024 Sep 23;25(18):10211. doi: 10.3390/ijms251810211. PMID: 39337696; PMCID: PMC11432374.

558．Nystuen KL, McNamee SM, Akula M, Holton KM, DeAngelis MM, Haider NB. Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments. Bioengineering (Basel). 2024 Jan 1;11(1):45. doi: 10.3390/bioengineering11010045. PMID: 38247923; PMCID: PMC10813760.

559．Yang M, Sun D, Wang Y, Yan M, Zheng J, Ren J. Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions. Front Cardiovasc Med. 2022 Feb 7;8:831734. doi: 10.3389/fcvm.2021.831734. PMID: 35198608; PMCID: PMC8858826.

560．Vecchio I, Sorrentino L, Paoletti A, Marra R, Arbitrio M. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. J Cent Nerv Syst Dis. 2021 Jul 7;13:11795735211029113. doi: 10.1177/11795735211029113. PMID: 34285627; PMCID: PMC8267037.

561．Șovrea AS, Boșca AB, Dronca E, Constantin AM, Crintea A, Suflețel R, Ștefan RA, Ștefan PA, Onofrei MM, Tschall C, Crivii CB. Non-Drug and Non-Invasive Therapeutic Options in Alzheimer's Disease. Biomedicines. 2025 Jan 1;13(1):84. doi: 10.3390/biomedicines13010084. PMID: 39857667; PMCID: PMC11760896.

562．Zhu Y, Xu H, Yu C, Jiang W, Hou X, Ma M, Wu J. Polymers for the treatment of Alzheimer's disease. Front Pharmacol. 2025 Jan 29;16:1512941. doi: 10.3389/fphar.2025.1512941. PMID: 39944627; PMCID: PMC11813879.

563．Hager K. Alzheimer-Erkrankung – welche Substanzen befinden sich derzeit in Phase-III-Studien? [Alzheimer's disease-Which substances are at present in phase III studies?]. Nervenarzt. 2022 Oct;93(10):1028-1034. German. doi: 10.1007/s00115-022-01275-5. Epub 2022 Mar 14. PMID: 35288774; PMCID: PMC9534798.

564．Wang M, Zhang H, Liang J, Huang J, Chen N. Exercise suppresses neuroinflammation for alleviating Alzheimer's disease. J Neuroinflammation. 2023 Mar 19;20(1):76. doi: 10.1186/s12974-023-02753-6. PMID: 36935511; PMCID: PMC10026496.

565．Ren R, Qi J, Lin S, Liu X, Yin P, Wang Z, Tang R, Wang J, Huang Q, Li J, Xie X, Hu Y, Cui S, Zhu Y, Yu X, Wang P, Zhu Y, Wang Y, Huang Y, Hu Y, Wang Y, Li C, Zhou M, Wang G. The China Alzheimer Report 2022. Gen Psychiatr. 2022 Mar 11;35(1):e100751. doi: 10.1136/gpsych-2022-100751. PMID: 35372787; PMCID: PMC8919463.

566．Xu Lou I, Chen J, Ali K, Shaikh AL, Chen Q. Mapping new pharmacological interventions for cognitive function in Alzheimer's disease: a systematic review of randomized clinical trials. Front Pharmacol. 2023 Jun 1;14:1190604. doi: 10.3389/fphar.2023.1190604. PMID: 37332343; PMCID: PMC10270324.

567．Bai H, Feng XF. Searching for new drugs to treat Alzheimer's disease dementia through multiple pathways. World J Clin Cases. 2025 Jan 6;13(1):100833. doi: 10.12998/wjcc.v13.i1.100833. PMID: 39764533; PMCID: PMC11577518.

568．Bateman RJ, Smith J, Donohue MC, Delmar P, Abbas R, Salloway S, Wojtowicz J, Blennow K, Bittner T, Black SE, Klein G, Boada M, Grimmer T, Tamaoka A, Perry RJ, Turner RS, Watson D, Woodward M, Thanasopoulou A, Lane C, Baudler M, Fox NC, Cummings JL, Fontoura P, Doody RS; GRADUATE I and II Investigators and the Gantenerumab Study Group. Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease. N Engl J Med. 2023 Nov 16;389(20):1862-1876. doi: 10.1056/NEJMoa2304430. PMID: 37966285; PMCID: PMC10794000.

569．Cui T, Yu P, Feng X, Song Q, Yang D, Li M, Feng L. Elucidation of the inhibitory effects of Jiedu Yizhi formula on neuronal apoptosis in the treatment of Alzheimer's disease based on network pharmacology and in vivo experiments. Metab Brain Dis. 2024 Nov 22;40(1):38. doi: 10.1007/s11011-024-01444-2. PMID: 39576427.

570．Gong CX, Dai CL, Liu F, Iqbal K. Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer's Disease. Front Aging Neurosci. 2022 Feb 9;14:837649. doi: 10.3389/fnagi.2022.837649. PMID: 35222001; PMCID: PMC8864545.

571．Xiao QY, Ye TY, Wang XL, Qi DM, Cheng XR. Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome. Front Cell Infect Microbiol. 2023 Jan 13;12:1048513. doi: 10.3389/fcimb.2022.1048513. PMID: 36710967; PMCID: PMC9880330.

572．Lo TY, Chan ASL, Cheung ST, Yung LY, Leung MMH, Wong YH. Multi-target regulatory mechanism of Yang Xin Tang - a traditional Chinese medicine against dementia. Chin Med. 2023 Aug 16;18(1):101. doi:  10.1186/s13020-023-00813-w. PMID: 37587513; PMCID: PMC10428601.

573．Liu X, Liu Y, Liu J, Zhang H, Shan C, Guo Y, Gong X, Cui M, Li X, Tang M. Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence. Neural Regen Res. 2024 Apr;19(4):833-845. doi: 10.4103/1673-5374.382223. PMID: 37843219; PMCID: PMC10664138.

574．Rippee-Brooks MD, Wu W, Dong J, Pappolla M, Fang X, Bao X. Viral Infections, Are They a Trigger and Risk Factor of Alzheimer's Disease? Pathogens. 2024 Mar 8;13(3):240. doi: 10.3390/pathogens13030240. PMID: 38535583; PMCID: PMC10974111.

575．Alfei S, Zuccari G. Ellagic Acid: A Green Multi-Target Weapon That Reduces Oxidative Stress and Inflammation to Prevent and Improve the Condition of Alzheimer's Disease. Int J Mol Sci. 2025 Jan 20;26(2):844. doi: 10.3390/ijms26020844. PMID: 39859559; PMCID: PMC11766176.

576．Panchal SK, John OD, Mathai ML, Brown L. Anthocyanins in Chronic Diseases: The Power of Purple. Nutrients. 2022 May 23;14(10):2161. doi: 10.3390/nu14102161. PMID: 35631301; PMCID: PMC9142943.

577．Zhu M, Liu X, Ye Y, Yan X, Cheng Y, Zhao L, Chen F, Ling Z. Gut Microbiota: A Novel Therapeutic Target for Parkinson's Disease. Front Immunol. 2022 Jun 24;13:937555. doi: 10.3389/fimmu.2022.937555. PMID: 35812394; PMCID: PMC9263276.

578．Zhong SR, Kuang Q, Zhang F, Chen B, Zhong ZG. Functional roles of the microbiota-gut-brain axis in Alzheimer's disease: Implications of gut microbiota-targeted therapy. Transl Neurosci. 2021 Dec 28;12(1):581-600. doi: 10.1515/tnsci-2020-0206. PMID: 35070442; PMCID: PMC8724360.

579．Jeong H, Shin H, Hong S, Kim Y. Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer's Disease Therapeutics. Exp Neurobiol. 2022 Apr 30;31(2):65-88. doi: 10.5607/en22004. PMID: 35673997; PMCID: PMC9194638.

580．Martins B, Vieira M, Delerue-Matos C, Grosso C, Soares C. Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae- Derived Compounds with Neuroprotective Activity: A Comprehensive Review. Mar Drugs. 2022 May 28;20(6):362. doi: 10.3390/md20060362. PMID: 35736165; PMCID: PMC9227170.

581． Jimenez-García AM, Villarino M, Arias N. A systematic review and meta- analysis of basal microbiota and cognitive function in Alzheimer's disease: A potential target for treatment or a contributor to disease progression? Alzheimers Dement (Amst). 2024 Dec 27;16(4):e70057. doi: 10.1002/dad2.70057. PMID: 39734582; PMCID: PMC11672027.

582．Kim AY, Al Jerdi S, MacDonald R, Triggle CR. Alzheimer's disease and its treatment-yesterday, today, and tomorrow. Front Pharmacol. 2024 May 24;15:1399121. doi: 10.3389/fphar.2024.1399121. PMID: 38868666; PMCID: PMC11167451.

583．Puranik N, Song M. Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target. Molecules. 2024 Dec 5;29(23):5744. doi: 10.3390/molecules29235744. PMID: 39683904; PMCID: PMC11643865.

584．Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024 Aug 23;9(1):211. doi: 10.1038/s41392-024-01911-3. PMID: 39174535; PMCID: PMC11344989.

585．Liu P, Wang Y, Sun Y, Peng G. Neuroinflammation as a Potential Therapeutic Target in Alzheimer's Disease. Clin Interv Aging. 2022 Apr 29;17:665-674. doi: 10.2147/CIA.S357558. PMID: 35520949; PMCID: PMC9064449.

586．Lee JY, Wong CY, Koh RY, Lim CL, Kok YY, Chye SM. Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review. Yale J Biol Med. 2024 Jun 28;97(2):205-224. doi: 10.59249/JNKB9714. PMID: 38947104; PMCID: PMC11202106.

587．Sighencea MG, Popescu RS, Trifu SC. From fundamentals to innovation in Alzheimer’s disease: molecular findings and revolutionary therapies. Int J Mol Sci.2024;25(22):12311.

588．Balestri W, Sharma R, da Silva VA, et al. Modeling the neuroimmune system in Alzheimer’s and Parkinson’s disease[J]. J Neuroinflammation.2024;21(1):32.

589．Strongyli E, Evangelidis P, Sakellari I, et al.Change in Neurocognitive Function in Patients Who Receive CAR-T Cell Therapies: A Steep Hill to Climb[J]. Pharmaceuticals (Basel).2024;17(5):591.

590．Liu Q, Ruan K, An Z, et al. Updated review of research on the role of the gut microbiota and microbiota-derived metabolites in acute pancreatitis progression and inflammation-targeted therapy[J].Int J Biol Sci.2025;21(3):1242-1258.

591．Almasi F, Abbasloo F, Soltani N, et al. Biology, pathology and targetd therapy of exosomal cargoes in parkinson’s disease: advances and challenges[J]. Mol Neurobiol.2025 Feb 25.

592．Li R, Miao Z, Liu Y, et al. The brain-gut-bone axis in neurodegenerative disease: insights, challenges, and future prospects.Adv Sci(Weinh)[J].2024;11(38):e22307971.

593．Li M, Tong F, Wu B, et al.Radiation-Induced Brain Injury: Mechanistic Insights and the Promise of Gut-Brain Axis Therapies[J].Brain Sci.2024;14(12):1295.

594．Li R, Miao Z, Liu Y, et al. The Brain-Gut-Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects[J]. Adv Sci(Weinh).2024;11(38):e2307971.

595．Lu J, Pan Q, Zhou J, Weng Y, Chen K, Shi L, Zhu G, Chen C, Li L, Geng M, Zhang Z. Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China. J Pharm Anal. 2022 Feb;12(1):145-155. doi: 10.1016/j.jpha.2021.06.001. Epub 2021 Jun 5. PMID: 35573885; PMCID: PMC9073255.

596．Yang X, Zhangyi Z, Yu A, Zhou Q, Xia A, Qiu J, Cai M, Chu X, Li L, Feng Z, Luo Z, Sun G, Zhang J, Geng M, Chen S, Xie Z. GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities. CNS Neurosci Ther. 2024 Jul;30(7):e14847. doi: 10.1111/cns.14847. PMID: 38973196; PMCID: PMC11228355.

597．Costa M, Soares C, Silva A, Barroso MF, Simões P, Ferreira M, Gameiro P, Grosso C, Delerue-Matos C. Optimization of Nanoencapsulation of Codium tomentosum Extract and Its Potential Application in Yogurt Fortification. Mar Drugs. 2025 Mar 28;23(4):147. doi: 10.3390/md23040147. PMID: 40278268; PMCID: PMC12028962.

598．Guo Z, Gao B, Fan M, Chen L, Zhang C, Liang X, Su W, Xie Y. Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer's Disease in Rats by LC-MS/MS. Molecules. 2023 Mar 4;28(5):2377. doi: 10.3390/molecules28052377. PMID: 36903623; PMCID: PMC10005075.

599．Shannon E, Conlon M, Hayes M. Seaweed Components as Potential Modulators of the Gut Microbiota. Mar Drugs. 2021 Jun 23;19(7):358. doi: 10.3390/md19070358. PMID: 34201794; PMCID: PMC8303941.

600．Yang C, Xue M, He Y, Yin H, Yang C, Zhong D, Zeng H, Zheng Y, Diao X. Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]BS1801, a Selenium-Containing Drug Candidate, in Rats. Molecules. 2023 Dec 15;28(24):8102. doi: 10.3390/molecules28248102. PMID: 38138590; PMCID: PMC10745422.

601．Zhu Y, Xu H, Yu C, Jiang W, Hou X, Ma M, Wu J. Polymers for the treatment of Alzheimer's disease. Front Pharmacol. 2025 Jan 29;16:1512941. doi: 10.3389/fphar.2025.1512941. PMID: 39944627; PMCID: PMC11813879.

602．Sun L, Xu M, Shi Y, Xu Y, Chen J, He L. Decoding psychosis: from national genome project to national brain project. Gen Psychiatr. 2022 Sep 22;35(4):e100889. doi: 10.1136/gpsych-2022-100889. PMID: 36248024; PMCID: PMC9511649.

603．Yang Y, Qiu L. Research Progress on the Pathogenesis, Diagnosis, and Drug Therapy of Alzheimer's Disease. Brain Sci. 2024 Jun 9;14(6):590. doi: 10.3390/brainsci14060590. PMID: 38928590; PMCID: PMC11201671.

604．Mohamed EM, H Elmaidomy A, Alaaeldin R, Alsenani F, Altemani FH, Algehainy NA, Alanazi MA, Bagalagel A, Althagafi A, Elrehany MA, Abdelmohsen UR. Anti- Alzheimer Potential of a New (+)-Pinitol Glycoside Isolated from Tamarindus indica Pulp: In Vivo and In Silico Evaluations. Metabolites. 2023 Jun 7;13(6):732. doi: 10.3390/metabo13060732. PMID: 37367890; PMCID: PMC10304100.

605．Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17;19(1):18. doi: 10.1186/s13024-023-00700-w. Erratum in: Mol Neurodegener. 2024 Oct 10;19(1):70. doi: 10.1186/s13024-024-00764-2. PMID: 38365827; PMCID: PMC10874048.

606．Huang LK, Kuan YC, Lin HW, Hu CJ. Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update. J Biomed Sci. 2023 Oct 2;30(1):83. doi: 10.1186/s12929-023-00976-6. PMID: 37784171; PMCID: PMC10544555.

607．Syed YY. Sodium Oligomannate: First Approval. Drugs. 2020 Mar;80(4):441-444. doi: 10.1007/s40265-020-01268-1. Erratum in: Drugs. 2020 Mar;80(4):445-446. doi: 10.1007/s40265-020-01274-3. PMID: 32020555.

608．Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K. Alzheimer's disease drug development pipeline: 2020. Alzheimers Dement (N Y). 2020 Jul 16;6(1):e12050. doi: 10.1002/trc2.12050. PMID: 32695874; PMCID: PMC7364858.

609．Yan M, Man S, Sun B, Ma L, Guo L, Huang L, Gao W. Gut liver brain axis in diseases: the implications for therapeutic interventions. Signal Transduct Target Ther. 2023 Dec 6;8(1):443. doi: 10.1038/s41392-023-01673-4. PMID: 38057297; PMCID: PMC10700720.

610．Song C, Shi J, Zhang P, Zhang Y, Xu J, Zhao L, Zhang R, Wang H, Chen H. Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond. Transl Neurodegener. 2022 Mar 18;11(1):18. doi: 10.1186/s40035-022-00292-3. PMID: 35300725; PMCID: PMC8932191.

611．Hu D, Jin Y, Hou X, Zhu Y, Chen D, Tai J, Chen Q, Shi C, Ye J, Wu M, Zhang H, Lu Y. Application of Marine Natural Products against Alzheimer's Disease: Past, Present and Future. Mar Drugs. 2023 Jan 5;21(1):43. doi: 10.3390/md21010043. PMID: 36662216; PMCID: PMC9867307.

612．Kiss E, Kins S, Gorgas K, Venczel Szakács KH, Kirsch J, Kuhse J. Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer's Disease. Int J Mol Sci. 2024 Apr 9;25(8):4165. doi: 10.3390/ijms25084165. PMID: 38673751; PMCID: PMC11049906.

613．Ettcheto M, Busquets O, Cano A, Sánchez-Lopez E, Manzine PR, Espinosa-Jimenez T, Verdaguer E, Sureda FX, Olloquequi J, Castro-Torres RD, Auladell C, Folch J, Casadesús G, Camins A. Pharmacological Strategies to Improve Dendritic Spines in Alzheimer's Disease. J Alzheimers Dis. 2021;82(s1):S91-S107. doi: 10.3233/JAD-201106. PMID: 33325386; PMCID: PMC9853464.

614．Anderson C, Bucholc M, McClean PL, Zhang SD. The Potential of a Stratified Approach to Drug Repurposing in Alzheimer's Disease. Biomolecules. 2023 Dec 21;14(1):11. doi: 10.3390/biom14010011. PMID: 38275752; PMCID: PMC10813465.

615．Jannat K, Balakrishnan R, Han JH, Yu YJ, Kim GW, Choi DK. The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source. Cells. 2023 Nov 18;12(22):2652. doi: 10.3390/cells12222652. PMID: 37998387; PMCID: PMC10670678.

616．Saiyasit N, Butlig ER, Chaney SD, Traylor MK, Hawley NA, Randall RB, Bobinger HV, Frizell CA, Trimm F, Crook ED, Lin M, Hill BD, Keller JL, Nelson AR. Neurovascular Dysfunction in Diverse Communities With Health Disparities- Contributions to Dementia and Alzheimer's Disease. Front Neurosci. 2022 Jun 29;16:915405. doi: 10.3389/fnins.2022.915405. PMID: 35844216; PMCID: PMC9279126.

617．Jarne-Ferrer J, Griñán-Ferré C, Bellver-Sanchis A, Vázquez S, Muñoz-Torrero D, Pallàs M. A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer's Disease Mice Models. Pharmaceuticals (Basel). 2022 Jul 22;15(8):908. doi: 10.3390/ph15080908. PMID: 35893732; PMCID: PMC9394299.

618．Yang X, Gao X, Jiang X, Yue K, Luo P. Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases. Neural Regen Res. 2025 Nov 1;20(11):3076-3094. doi: 10.4103/NRR.NRR-D-24-00462. Epub 2024 Oct 22. PMID: 39435635; PMCID: PMC11881733.

619．Austad SN, Ballinger S, Buford TW, Carter CS, Smith DL Jr, Darley-Usmar V, Zhang J. Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease. Acta Pharm Sin B. 2022 Feb;12(2):511-531. doi: 10.1016/j.apsb.2021.06.014. Epub 2021 Jun 30. PMID: 35256932; PMCID: PMC8897048.

620．Martins B, Vieira M, Delerue-Matos C, Grosso C, Soares C. Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae- Derived Compounds with Neuroprotective Activity: A Comprehensive Review. Mar Drugs. 2022 May 28;20(6):362. doi: 10.3390/md20060362. PMID: 35736165; PMCID: PMC9227170.

621．De Simone A, Tumiatti V, Andrisano V, Milelli A. Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery? J Med Chem. 2021 Jan 14;64(1):26-41. doi: 10.1021/acs.jmedchem.0c00931. Epub  2020 Dec 21. PMID: 33346659; PMCID: PMC8016207.

622．Abitbol A, Mallard B, Tiralongo E, Tiralongo J. Mushroom Natural Products in Neurodegenerative Disease Drug Discovery. Cells. 2022 Dec 6;11(23):3938. doi: 10.3390/cells11233938. PMID: 36497196; PMCID: PMC9740391.

623．Dai Z, Hu T, Wei J, Wang X, Cai C, Gu Y, Hu Y, Wang W, Wu Q, Fang J. Network-based identification and mechanism exploration of active ingredients against Alzheimer's disease via targeting endoplasmic reticulum stress from traditional chinese medicine. Comput Struct Biotechnol J. 2023 Dec 20;23:506-519. doi: 10.1016/j.csbj.2023.12.017. PMID: 38261917; PMCID: PMC10796977.

624．Zhang Y, Tian J, Ni J, Wei M, Li T, Shi J. Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer's disease: a systematic review and meta-analysis. Front Pharmacol. 2024 Jan 12;14:1268000. doi: 10.3389/fphar.2023.1268000. PMID: 38283842; PMCID: PMC10815298.

625．Liu P, Wang Y, Sun Y, Peng G. Neuroinflammation as a Potential Therapeutic Target in Alzheimer's Disease. Clin Interv Aging. 2022 Apr 29;17:665-674. doi: 10.2147/CIA.S357558. PMID: 35520949; PMCID: PMC9064449.

626．Xie J, Zhong C, Wang T, He D, Lu L, Yang J, Yuan Z, Zhang J. Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version. Front Pharmacol. 2022 Jun 27;13:937075. doi: 10.3389/fphar.2022.937075. PMID: 35833035; PMCID: PMC9271619.

627．Uliassi E, de Oliveira AS, de Camargo Nascente L, Romeiro LAS, Bolognesi ML. Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease. Molecules. 2021 Sep 7;26(18):5441. doi: 10.3390/molecules26185441. PMID: 34576912; PMCID: PMC8466601.

628．Yoon JH, Hwang J, Son SU, Choi J, You SW, Park H, Cha SY, Maeng S. How Can Insulin Resistance Cause Alzheimer's Disease? Int J Mol Sci. 2023 Feb 9;24(4):3506. doi: 10.3390/ijms24043506. PMID: 36834911; PMCID: PMC9966425.

629．Chen Y, Yu Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. J Neuroinflammation. 2023 Jul 14;20(1):165. doi: 10.1186/s12974-023-02853-3. PMID: 37452321; PMCID: PMC10349496.

630．Yu TW, Lane HY, Lin CH. Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review. Int J Mol Sci. 2021 Jul 30;22(15):8208. doi: 10.3390/ijms22158208. PMID: 34360973; PMCID: PMC8348485.

631．Cummings J. Drug Development for Psychotropic, Cognitive-Enhancing, and Disease-Modifying Treatments for Alzheimer's Disease. J Neuropsychiatry Clin Neurosci. 2021 Winter;33(1):3-13. doi: 10.1176/appi.neuropsych.20060152. Epub 2020 Oct 28. PMID: 33108950; PMCID: PMC7989572.

632．Cao X, Du X, Jiao H, An Q, Chen R, Fang P, Wang J, Yu B.  Carbohydrate-based drugs launched during 2000-2021. Acta Pharm Sin B. 2022 Oct;12(10):3783-3821. doi: 10.1016/j.apsb.2022.05.020. Epub 2022 May 23. PMID: 36213536; PMCID: PMC9532563.

633．Brooker H, Williams G, Hampshire A, Corbett A, Aarsland D, Cummings J, Molinuevo JL, Atri A, Ismail Z, Creese B, Fladby T, Thim-Hansen C, Wesnes K, Ballard C. FLAME: A computerized neuropsychological composite for trials in early dementia. Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12098. doi: 10.1002/dad2.12098. PMID: 33088895; PMCID: PMC7560493.

634．Lu J, Pan Q, Zhou J, Weng Y, Chen K, Shi L, Zhu G, Chen C, Li L, Geng M, Zhang Z. Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China. J Pharm Anal. 2022 Feb;12(1):145-155. doi: 10.1016/j.jpha.2021.06.001. Epub 2021 Jun 5. PMID: 35573885; PMCID: PMC9073255.

635．Song M, Fan X. Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer's Disease: Finding Potential Therapeutic Targets. Int J Mol Sci. 2023 May 7;24(9):8398. doi: 10.3390/ijms24098398. PMID: 37176104; PMCID: PMC10179273.

636．Martins M, Silva R, M M Pinto M, Sousa E. Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease. Pharmaceuticals (Basel). 2020 Sep 11;13(9):242. doi: 10.3390/ph13090242. PMID: 32933034; PMCID: PMC7558913.

637．Ramesh M, Govindaraju T. Multipronged diagnostic and therapeutic strategies for Alzheimer's disease. Chem Sci. 2022 Oct 14;13(46):13657-13689. doi: 10.1039/d2sc03932j. PMID: 36544728; PMCID: PMC9710308.

638．Yan N, Shi XL, Tang LQ, Wang DF, Li X, Liu C, Liu ZP. Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer's disease. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1724-1736. doi: 10.1080/14756366.2022.2086867. PMID: 35698879; PMCID: PMC9225722.

639．Yu CC, Du YJ, Wang SQ, Liu LB, Shen F, Wang L, Lin YF, Kong LH. Experimental Evidence of the Benefits of Acupuncture for Alzheimer's Disease: An Updated Review. Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. PMID: 33408601; PMCID: PMC7779610.

640．Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024 Aug 23;9(1):211. doi: 10.1038/s41392-024-01911-3. PMID: 39174535; PMCID: PMC11344989.

641．Gonçalves PB, Sodero ACR, Cordeiro Y. Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases. Biomolecules. 2021 May 20;11(5):767. doi: 10.3390/biom11050767. PMID: 34065606; PMCID: PMC8160836.

642．Tan W, Qi L, Hu X, Tan Z. Research progress in traditional Chinese medicine in the treatment of Alzheimer's disease and related dementias. Front Pharmacol. 2022 Nov 24;13:921794. doi: 10.3389/fphar.2022.921794. PMID: 36506569; PMCID: PMC9729772.

643．Yin T, Liu Y, Ji W, Zhuang J, Chen X, Gong B, Chu J, Liang W, Gao J, Yin Y. Engineered mesenchymal stem cell-derived extracellular vesicles: A state-of-the- art multifunctional weapon against Alzheimer's disease. Theranostics. 2023 Feb 5;13(4):1264-1285. doi: 10.7150/thno.81860. PMID: 36923533; PMCID: PMC10008732.

644．Sochocka M, Ochnik M, Sobczyński M, Gębura K, Zambrowicz A, Naporowski P, Leszek J. Ginkgo Biloba Leaf Extract Improves an Innate Immune Response of Peripheral Blood Leukocytes of Alzheimer's Disease Patients. Nutrients. 2022 May 11;14(10):2022. doi: 10.3390/nu14102022. PMID: 35631163; PMCID: PMC9147830.

645．Sampietro A, Pérez-Areales FJ, Martínez P, Arce EM, Galdeano C, Muñoz- Torrero D. Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis. Pharmaceuticals (Basel). 2022 Apr 28;15(5):545. doi: 10.3390/ph15050545. PMID: 35631371; PMCID: PMC9146451.

646．Chen H, Zeng Y, Wang D, Li Y, Xing J, Zeng Y, Liu Z, Zhou X, Fan H. Neuroinflammation of Microglial Regulation in Alzheimer's Disease: Therapeutic Approaches. Molecules. 2024 Mar 26;29(7):1478. doi: 10.3390/molecules29071478. PMID: 38611758; PMCID: PMC11013124.

647．Aziz N, Wal P, Patel A, Prajapati H. A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7307-7336. doi: 10.1007/s00210-024-03109-4. Epub 2024 May 11. PMID: 38734839.

648．Lalhmangaihzuala S, Vanlaldinpuia K, Khiangte V, Laldinpuii Z, Liana T, Lalhriatpuia C, Pachuau Z. Therapeutic applications of carbohydrate-based compounds: a sweet solution for medical advancement. Mol Divers. 2024 Dec;28(6):4553-4579. doi: 10.1007/s11030-024-10810-2. Epub 2024 Mar 30. PMID: 38554170.

649．Pozdnyakov DI, Zolotych DS, Rukovitsyna VM, Oganesyan ET. Chromone derivatives suppress neuroinflammation and improve mitochondrial function in the sporadic form of Alzheimer's disease under experimental conditions. Iran J Basic Med Sci. 2022 Jul;25(7):871-881. doi: 10.22038/IJBMS.2022.65377.14387. PMID: 36033947; PMCID: PMC9392576.

650．Ngu EL, Tan CY, Lai NJ, Wong KH, Lim SH, Ming LC, Tan KO, Phang SM, Yow YY. Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia. Metabolites. 2022 Nov 20;12(11):1147. doi: 10.3390/metabo12111147. PMID: 36422287; PMCID: PMC9698046.

651．Yang X, Zhangyi Z, Yu A, Zhou Q, Xia A, Qiu J, Cai M, Chu X, Li L, Feng Z, Luo Z, Sun G, Zhang J, Geng M, Chen S, Xie Z. GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities. CNS Neurosci Ther. 2024 Jul;30(7):e14847. doi: 10.1111/cns.14847. PMID: 38973196; PMCID: PMC11228355.

652．Liu X, Liu Y, Liu J, Zhang H, Shan C, Guo Y, Gong X, Cui M, Li X, Tang M. Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence. Neural Regen Res. 2024 Apr;19(4):833-845. doi: 10.4103/1673-5374.382223. PMID: 37843219; PMCID: PMC10664138.

653．Barbosa M, Valentão P, Andrade PB. Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration. Mar Drugs. 2020 Dec 18;18(12):654. doi: 10.3390/md18120654. PMID: 33353007; PMCID: PMC7766193.

654．Peng D, Liu T, Lu H, Zhang L, Chen H, Huang Y, Hu B, Zhang Q. Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes. Theranostics. 2024 Nov 4;14(19):7623-7644. doi: 10.7150/thno.103596. PMID: 39659569; PMCID: PMC11626949.

655．Puranik N, Song M. Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target. Molecules. 2024 Dec 5;29(23):5744. doi: 10.3390/molecules29235744. PMID: 39683904; PMCID: PMC11643865.

656．Lee JY, Wong CY, Koh RY, Lim CL, Kok YY, Chye SM. Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review. Yale J Biol Med. 2024 Jun 28;97(2):205-224. doi: 10.59249/JNKB9714. PMID: 38947104; PMCID: PMC11202106.

657．Gao D, Li P, Gao F, Feng Y, Li X, Li D, Li Y, Xiao Y. Preparation and Multitarget Anti-AD Activity Study of Chondroitin Sulfate Lithium in AD Mice Induced by Combination of D-Gal/AlCl₃. Oxid Med Cell Longev. 2022 Nov 12;2022:9466166. doi: 10.1155/2022/9466166. PMID: 36411758; PMCID: PMC9675613.

658．Yu CC, Wang J, Ye SS, Gao S, Li J, Wang L, Jiang T, Wang XS, Li BC, Shu Q, Lu W, Du YJ, Kong LH. Preventive Electroacupuncture Ameliorates D-Galactose- Induced Alzheimer's Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3β/mTOR Signaling Pathway. Evid Based Complement Alternat Med. 2020 Apr 23;2020:1428752. doi: 10.1155/2020/1428752. PMID: 32382276; PMCID: PMC7195631.

659．Fasina OB, Li L, Chen D, Yi M, Xiang L, Qi J. Tetradecyl 2,3-Dihydroxybenzoate Improves Cognitive Function in AD Mice by Modulating Autophagy and Inflammation Through IPA and Hsc70 Targeting. Int J Mol Sci. 2024 Oct 31;25(21):11719. doi: 10.3390/ijms252111719. PMID: 39519271; PMCID: PMC11547019.

660．Pokrzyk J, Kulczyńska-Przybik A, Guzik-Makaruk E, Winkel I, Mroczko B. Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer's Disease. Int J Mol Sci. 2025 Feb 24;26(5):1935. doi: 10.3390/ijms26051935. PMID: 40076562; PMCID: PMC11900921.

661．Liu Y, Echeverria V, Xu Y. Editorial: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside. Front Pharmacol. 2020 Sep 23;11:585155. doi: 10.3389/fphar.2020.585155. PMID: 33071796; PMCID: PMC7538617.

662．Cao Y, Yu F, Lyu Y, Lu X. Promising candidates from drug clinical trials: Implications for clinical treatment of Alzheimer's disease in China. Front Neurol. 2022 Nov 15;13:1034243. doi: 10.3389/fneur.2022.1034243. PMID: 36457865; PMCID: PMC9706102.

663．Guo X, Gao L, Liu J, Lu W, Wang J, Qu Q. Public acceptability of lumbar puncture in the diagnosis of Alzheimer's disease: a questionnaire-based single center study in China. Am J Transl Res. 2023 Jun 15;15(6):4179-4187. PMID: 37434808; PMCID: PMC10331662.

664．Balkhi S, Di Spirito A, Poggi A, Mortara L. Immune Modulation in Alzheimer's Disease: From Pathogenesis to Immunotherapy. Cells. 2025 Feb 12;14(4):264. doi: 10.3390/cells14040264. PMID: 39996737; PMCID: PMC11853524.

665．Zhou G, Yin Y, Huan X, Zhuang Y, Xu S, Liu J, Liu S, Duan J. The Potential Role of the Brain-gut Axis in the Development and Progression of Alzheimer's Disease. J Transl Int Med. 2022 Jul 2;10(2):89-91. doi: 10.2478/jtim-2022-0016. PMID: 35959446; PMCID: PMC9328030.

666．Yu CC, Du YJ, Li J, Li Y, Wang L, Kong LH, Zhang YW. Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update. Aging Dis. 2022 Jul 11;13(4):1092-1105. doi: 10.14336/AD.2021.1205. PMID: 35855345; PMCID: PMC9286922.

667．Gao F, Chen J, Zhou Y, Cheng L, Hu M, Wang X. Recent progress of small- molecule-based theranostic agents in Alzheimer's disease. RSC Med Chem. 2023 Sep 14;14(11):2231-2245. doi: 10.1039/d3md00330b. PMID: 37974955; PMCID: PMC10650505.

668．Niu TT, Yin H, Xu BL, Yang TT, Li HQ, Sun Y, Liu GZ. Protective Effects of Ginkgolide on a Cellular Model of Alzheimer's Disease via Suppression of the NF- κB Signaling Pathway. Appl Biochem Biotechnol. 2022 Jun;194(6):2448-2464. doi: 10.1007/s12010-022-03828-5. Epub 2022 Feb 7. PMID: 35129804; PMCID: PMC9117391.

669．Klose J, Griehl C, Roßner S, Schilling S. Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. Biomolecules. 2022 May 12;12(5):694. doi: 10.3390/biom12050694. PMID: 35625622; PMCID: PMC9139049.

670．Bloomingdale P, Karelina T, Ramakrishnan V, Bakshi S, Véronneau-Veilleux F, Moye M, Sekiguchi K, Meno-Tetang G, Mohan A, Maithreye R, Thomas VA, Gibbons F, Cabal A, Bouteiller JM, Geerts H. Hallmarks of neurodegenerative disease: A systems pharmacology perspective. CPT Pharmacometrics Syst Pharmacol. 2022 Nov;11(11):1399-1429. doi: 10.1002/psp4.12852. Epub 2022 Aug 17. PMID: 35894182; PMCID: PMC9662204.

671．Chen D, Chen Q, Qin X, Tong P, Peng L, Zhang T, Xia C. Development and evolution of human glutaminyl cyclase inhibitors (QCIs): an alternative promising approach for disease-modifying treatment of Alzheimer's disease. Front Aging Neurosci. 2023 Aug 3;15:1209863. doi: 10.3389/fnagi.2023.1209863. PMID: 37600512; PMCID: PMC10435661.

672．Vecchio I, Sorrentino L, Paoletti A, Marra R, Arbitrio M. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. J Cent Nerv Syst Dis. 2021 Jul 7;13:11795735211029113. doi: 10.1177/11795735211029113. PMID: 34285627; PMCID: PMC8267037.

673．Zhan Y, Al-Nusaif M, Ding C, Zhao L, Dong C. The potential of the gut microbiome for identifying Alzheimer's disease diagnostic biomarkers and future therapies. Front Neurosci. 2023 Apr 27;17:1130730. doi: 10.3389/fnins.2023.1130730. PMID: 37179559; PMCID: PMC10174259.

674．Hannan MA, Dash R, Haque MN, Mohibbullah M, Sohag AAM, Rahman MA, Uddin MJ, Alam M, Moon IS. Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances. Mar Drugs. 2020 Jul 1;18(7):347. doi: 10.3390/md18070347. PMID: 32630301; PMCID: PMC7401253.

675．Dai CL, Liu F, Iqbal K, Gong CX. Gut Microbiota and Immunotherapy for Alzheimer's Disease. Int J Mol Sci. 2022 Dec 3;23(23):15230. doi: 10.3390/ijms232315230. PMID: 36499564; PMCID: PMC9741026.

676．Wang T, Jia H. The Sigma Receptors in Alzheimer's Disease: New Potential Targets for Diagnosis and Therapy. Int J Mol Sci. 2023 Jul 27;24(15):12025. doi: 10.3390/ijms241512025. PMID: 37569401; PMCID: PMC10418732.

677．Zhang F, Zhong RJ, Cheng C, Li S, Le WD. New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2021 Sep;42(9):1382-1389. doi: 10.1038/s41401-020-00565-5. Epub 2020 Dec 2. PMID: 33268824; PMCID: PMC8379190.

678．Trisal A, Singh I, Garg G, Jorwal K, Singh AK. Gut-brain axis and brain health: modulating neuroinflammation, cognitive decline, and neurodegeneration. 3 Biotech. 2025 Jan;15(1):25. doi: 10.1007/s13205-024-04187-0. Epub 2024 Dec 27. PMID: 39735610; PMCID: PMC11680542.

679．Jia C, Chai J, Zhang S, Sun Y, He L, Sang Z, Chen D, Zheng X. The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments. Mar Drugs. 2025 Feb 20;23(3):91. doi: 10.3390/md23030091. PMID: 40137277; PMCID: PMC11943648.

680．Chu J, Zhang W, Liu Y, Gong B, Ji W, Yin T, Gao C, Liangwen D, Hao M, Chen C, Zhuang J, Gao J, Yin Y. Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease. Neural Regen Res. 2024 Jan;19(1):100-115. doi: 10.4103/1673-5374.374137. PMID: 37488851; PMCID: PMC10479833.

681．Almeida ZL, Vaz DC, Brito RMM. Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis. Mol Neurobiol. 2025 Apr;62(4):4391-4419. doi: 10.1007/s12035-024-04543-4. Epub 2024 Oct 24. PMID: 39446217; PMCID: PMC11880078.

682．Nada H, Elkamhawy A, Lee K.Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations[J].Peer J.2022;10:e14120.

683．Riu F, Ruda A, Engström O, et al.A Lead-Based Fragment Library Screening of the Glycosyltransferase WaaG from Escherichia coli[J].Pharmaceuticals(Basel).2022;15(2):209.

684．Yang X, Zhangyi Z, Yu A, et al. GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities[J].Cns Neuroscience&Therapeutics. 2024;30(7):e14847.

685．Lee JY, Wong CY, Koh RY, et al.Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review[J].Yale J Biol Med.2024;97(2):205-224.

686．Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17;19(1):18. doi: 10.1186/s13024-023-00700-w. Erratum in: Mol Neurodegener. 2024 Oct 10;19(1):70. doi: 10.1186/s13024-024-00764-2. PMID: 38365827; PMCID: PMC10874048.

687．Wang X, Xie Z, Yuan J, Jin E, Lian W, Chang S, Sun G, Feng Z, Xu H, Du C, Yang X, Xia A, Qiu J, Zhang Q, Lin F, Liu J, Li L, Du X, Xiao Z, Yi Z, Luo Z, Ge C, Li R, Zheng M, Jiang Y, Wang T, Zhang J, Guo Q, Geng M. Sodium oligomannate disrupts the adherence of Rib^high bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice. Cell Discov. 2024 Nov 19;10(1):115. doi: 10.1038/s41421-024-00725-5. PMID: 39557828; PMCID: PMC11573985.

688．Costa M, Soares C, Silva A, Barroso MF, Simões P, Ferreira M, Gameiro P, Grosso C, Delerue-Matos C. Optimization of Nanoencapsulation of Codium tomentosum Extract and Its Potential Application in Yogurt Fortification. Mar Drugs. 2025 Mar 28;23(4):147. doi: 10.3390/md23040147. PMID: 40278268; PMCID: PMC12028962.

689．Duan X, Nie Y, Xie X, Zhang Q, Zhu C, Zhu H, Chen R, Xu J, Zhang J, Yang C, Yu Q, Cai K, Wang Y, Tian W. Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway. Front Microbiol. 2024 Oct 18;15:1421608. doi: 10.3389/fmicb.2024.1421608. PMID: 39493843; PMCID: PMC11527610.

690．Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024 Aug 23;9(1):211. doi: 10.1038/s41392-024-01911-3. PMID: 39174535; PMCID: PMC11344989.

691．Adil NA, Omo-Erigbe C, Yadav H, Jain S. The Oral-Gut Microbiome-Brain Axis in Cognition. Microorganisms. 2025 Apr 3;13(4):814. doi: 10.3390/microorganisms13040814. PMID: 40284650; PMCID: PMC12029813.

692．Schaible P, Henschel J, Erny D. How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells. J Neuroinflammation. 2025 Mar 3;22(1):60. doi: 10.1186/s12974-025-03371-0. PMID: 40033338; PMCID: PMC11877772.

693．Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M,  Whiteson KL. Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice. Alzheimers Dement. 2024 Jul;20(7):4935-4950. doi: 10.1002/alz.13794. Epub 2024 Apr 4. PMID: 38572865; PMCID: PMC11247698.

694．Huang J, Qin TS, Bo Y, Li YJ, Liu RS, Yu Y, Li XD, He JC, Ma AX, Tao DP, Ren WJ, Peng J. The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective. Mol Neurobiol. 2025 Feb;62(2):1404-1414. doi: 10.1007/s12035-024-04322-1. Epub 2024 Jul 10. PMID: 38985257; PMCID: PMC11772545.

695．Pan L, Xie L, Yang W, Feng S, Mao W, Ye L, Cheng H, Wu X, Mao X. The role of brain-liver-gut Axis in neurological disorders. Burns Trauma. 2025 May 2;13:tkaf011. doi: 10.1093/burnst/tkaf011. PMID: 40321299; PMCID: PMC12048006.

696．Zhang S, Lu J, Jin Z, Xu H, Zhang D, Chen J, Wang J. Gut microbiota metabolites: potential therapeutic targets for Alzheimer's disease? Front Pharmacol. 2024 Sep 17;15:1459655. doi: 10.3389/fphar.2024.1459655. PMID: 39355779; PMCID: PMC11442227.

697．Ginsberg SD, Blaser MJ. Alzheimer's Disease Has Its Origins in Early Life via a Perturbed Microbiome. J Infect Dis. 2024 Sep 10;230(Supplement_2):S141-S149. doi: 10.1093/infdis/jiae200. PMID: 39255394; PMCID: PMC11385592.

698．Puranik N, Song M. Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target. Molecules. 2024 Dec 5;29(23):5744. doi: 10.3390/molecules29235744. PMID: 39683904; PMCID: PMC11643865.

699．Lee JY, Wong CY, Koh RY, Lim CL, Kok YY, Chye SM. Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer's Disease: A Review. Yale J Biol Med. 2024 Jun 28;97(2):205-224. doi: 10.59249/JNKB9714. PMID: 38947104; PMCID: PMC11202106.

700．Zhu Y, Xu H, Yu C, Jiang W, Hou X, Ma M, Wu J. Polymers for the treatment of Alzheimer's disease. Front Pharmacol. 2025 Jan 29;16:1512941. doi: 10.3389/fphar.2025.1512941. PMID: 39944627; PMCID: PMC11813879.

701．Jia C, Chai J, Zhang S, Sun Y, He L, Sang Z, Chen D, Zheng X. The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments. Mar Drugs. 2025 Feb 20;23(3):91. doi: 10.3390/md23030091. PMID: 40137277; PMCID: PMC11943648.

702．甘露特纳胶囊对轻中度阿尔茨海默病的临床疗效及肠道菌群的影响[J]. 朱志全;李季.吉林医学,2025(04)

703．基于认知重塑模式下重复经颅磁刺激对阿尔茨海默病患者认知功能的影响[J]. 付笑笑;刘欣欣;宋祎晗;付美霞.中国疗养医学,2025(03)

704．甘露特钠对老年阿尔茨海默病患者认知功能及对血清BDNF、IL-6的影响[J]. 王少艾;曾又晓;黄丽虹.深圳中西医结合杂志,2024(21)

705．小剂量奥氮平联合多奈哌齐对阿尔茨海默病患者临床症状及ADAS-cog评分的影响[J]. 刘广梅;张瑞岭.医药论坛杂志,2025(02)

706．甘露特钠胶囊单药治疗阿尔茨海默病、血管性认知障碍患者的疗效观察[D]. 张棚.昆明医科大学,2024

707．甘露特钠联合高频重复经颅磁刺激对阿尔茨海默病患者日常生活能力与智力水平的影响[J]. 夏俊博;焦桂红;李宁;王玉;冯玉龙;朱彦霞.新乡医学院学报,2024(08)

708．基于肠-脑轴理论探讨活血荣络方对APP/PS1双转基因小鼠LPS、TMAO、SCFAs水平的影响[D]. 李汝彬.湖南中医药大学,2024

709．甘露特钠胶囊联合多奈哌齐片治疗轻中度阿尔茨海默病的疗效及肠道菌群影响[D]. 张雨晗.浙江中医药大学,2024

710．中药药效物质基础研究方法与思路的进展与展望[J]. 巩亦萍;顾志荣;郭引兄;葛斌.中成药,2025(04)

711．中草药寡糖的提取分离、结构鉴定及分析方法研究进展[J]. 郭鸿;么蕊;范晶;郭晓晗;陈佳;段宝忠;王莹;杨建波;蔡伟;荆文光;程显隆;魏锋.药物分析杂志,2025(03)

712．糖类药物制药生产工艺及其质量控制方法研究进展[J]. 吴鸳鸯;金朱雨;谢升谷;申潜;刘小勤.医药导报,2024(08)

713．蜜环菌与银杏叶提取物配伍提高黄酮成分稳定性研究[D]. 赵禾苗.天津中医药大学,2024

714．氢溴酸加兰他敏联合甘露特钠治疗卒中后认知障碍的临床观察[J]. 郝丕达;王阳;苏冉;赵晓娟;唐宽飞;刘英科;商玉玲.阿尔茨海默病及相关病杂志,2024(02)

715．甘露特钠联合多奈哌齐治疗卒中后认知障碍的效果观察[J]. 苏冉;郝丕达;王阳;刘学凤;赵晓娟.慢性病学杂志,2024(02)

716．眼针治疗脾肾两虚型缺血性卒中后认知障碍的临床疗效评价[D]. 冯诗雨.辽宁中医药大学,2024

717．癫痫患儿血清基质金属蛋白酶-9、谷氨酸脱羧酶抗体、高迁移率族蛋白B1水平与左乙拉西坦治疗效果相关性及联合检测对治疗效果的预测价值[J]. 于乐;王沛;姜梦真.陕西医学杂志,2025(03)

718．青礞石治疗癫痫的作用机制及临床应用研究进展[J]. 吴广;铁梦意;杨俊红;朱健;潘知玉;刘金民;荆志伟.中国医院用药评价与分析,2024(11)

719．脑多肽对PCPA诱导的睡眠障碍小鼠5-羟色胺系统和肠道菌群的影响[J]. 黄欣然;王琳娜;代佳琪;宋楠楠;周程艳.河北大学学报(自然科学版),2024(05)

720．甘露特钠联合抗癫痫药物治疗阿尔茨海默病伴发癫痫及痴呆行为精神症状患者一例[J]. 贾伟丽;许岱昀;周国平.脑与神经疾病杂志,2024(09)

721．氯沙坦降低癫痫大鼠共患抑郁症风险的机制研究[J]. 潘楠楠;胡雅纯;廖雪珍;石喆;施海姗.中国神经精神疾病杂志,2024(02)

722．甘露特钠治疗伴有认知障碍的老年阿尔茨海默病患者的疗效分析[J]. 霍学智.中西医结合心血管病电子杂志,2024(05)

723．甘露特钠联合多奈哌齐治疗阿尔茨海默病的效果及对患者认知功能的影响[J]. 张黎军;王亚宇;李东丽;王凡;王朔;任静;李昆艳;王琼.中国实用医刊,2024(01)

724．基于神经炎症假说探讨阿尔茨海默病的中西医治疗进展[J]. 马思琴;邵晶;陈红霞.新疆中医药,2025(01)

725．以培养药学创新型人才为靶标的药理学教学改革探索[J]. 刘月阳;姚阳;李佳音;杨宇.化工管理,2024(32)

726．血清Aβ1-42、Bcl-2预测老年人认知功能障碍进展为阿尔茨海默病的价值[J]. 刘田;杨荣礼;韩慧萍.实用老年医学,2024(06)

727．术后认知功能障碍的炎症病因学研究进展[J]. 李虹辰;陶利军.现代医学与健康研究电子杂志,2023(18)

728．熊果酸锂对AD小鼠的认知功能影响及其机制研究[D]. 胡伟强.南昌大学,2024

729．基于Venturi自制低压给氧装置对胸腔镜单肺通气患者脑氧饱和度的目标导向实施探究其对术后认知功能的影响[D]. 何胤琰.浙江中医药大学,2024

730．美金刚分别联合甘露特纳与多奈哌齐治疗阿尔茨海默病对其认知功能的影响对比[J]. 缪默然;袁文林;王立阳.中外医疗,2024(16)

731．阿尔茨海默病采用甘露特钠配合多奈派齐治疗的效果[J]. 王特;赵伟;刘艳;刘娅;贺国华.慢性病学杂志,2023(09)

732．甘露特钠联合盐酸美金刚治疗老年中度阿尔茨海默病的临床效果[J]. 敬泽慧;李晓平.中国老年学杂志,2024(18)

733．甲状腺功能减退症患者血压、甲状腺激素与认知功能的相关性[J]. 宣颖莉;史烨;钟琴峰;姚建平.中国地方病防治,2024(03)

734．益气消瘿汤治疗桥本甲状腺炎效果观察[J]. 王奕涵;朱丹平.中国城乡企业卫生,2023(04)

735．基于SOCS1/3-JAK-STAT信号通路探讨软坚消瘿颗粒对EAT肝郁脾虚模型大鼠疗效机制的研究[D]. 王琳.辽宁中医药大学,2023

736．延续护理对阿尔茨海默病患者认知功能及生命质量的影响[A]. 张焱.第七届全国康复与临床药学学术交流会议,2024

737．重复经颅磁刺激联合音乐疗法对轻中度阿尔茨海默病患者前瞻性记忆及精神行为症状的影响[J]. 张银;杨晓芸;陶芳芳;吕丹萍.浙江中西医结合杂志,2025(03)

738．基于神经递质和肠道菌群探讨露甘露特钠胶囊联合盐酸多奈哌齐片治疗轻中度阿尔茨海默病的疗效[J]. 张颖;于小琪;卢福昌;王敏健;王双艳.现代生物医学进展,2024(20)

739．喹硫平对阿尔茨海默病患者精神行为症状、认知功能及神经递质的影响[J]. 张淑艳;赵倩;孙蜀宁.国际精神病学杂志,2024(04)

740．甘露特钠联合多奈哌齐治疗老年阿尔茨海默病患者疗效及对认知功能的影响研究[J]. 钱群花;张群英.罕少疾病杂志,2024(06)

741．甘露特钠联合多奈哌齐治疗阿尔茨海默病的临床效果[J]. 郝丕达;王阳;苏冉;赵晓娟;姜自远.慢性病学杂志,2024(06)

742．补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆临床研究[J]. 潘亚平;沈校康;魏红辉;孙宁宁.新中医,2024(10)

743．甘露特钠联合加兰他敏治疗血管性痴呆的临床研究[J]. 陈红艳;吴硕.现代药物与临床,2024(03)

744．阿尔茨海默病不同治疗方式研究新进展[J]. 袁行勇;姚春;陈炜;王晋平;黄钰铧;曲一荻;曾汉林;崔恩山;廖雨芯.广州医药,2024(03)

745．补阳还五汤联合电针神庭、百会对阿尔茨海默病患者认知功能及日常生活能力的影响[J]. 孙情;高燕玲;苏清岩;陈晓枫;程熙;戴清月;卢金华;陈星.中国老年保健医学,2024(01)

746．经颅磁刺激联合药物治疗阿尔茨海默病改善患者认知功能、精神行为症状及神经递质的效果[J]. 李冬梅.中国临床医生杂志,2023(10)

747．基于肠-脑轴理论探讨活血荣络方对APP/PS1双转基因小鼠LPS、TMAO、SCFAs水平的影响[D]. 李汝彬.湖南中医药大学,2024

748．甘露特钠胶囊联合多奈哌齐片治疗轻中度阿尔茨海默病的疗效及肠道菌群影响[D]. 张雨晗.浙江中医药大学,2024

749．新型氨基甲酸酯衍生物的设计、合成及其抗AD生物活性研究[D]. 米静.南阳师范学院,2023

750．多奈哌齐的两种剂型治疗阿尔茨海默病成本-效果分析[J]. 赵荧荧;居文祥;张小涵;路萝兰;沈爱宗.中国医院药学杂志,2024(23)

751．藿苓益智方治疗脾肾阳虚型阿尔茨海默病的临床观察[D]. 曹凌群.广西中医药大学,2023

752．脑深部电刺激联合甘露特钠治疗阿尔茨海默病的疗效及对血清趋化因子CX3CL1及ApoE4水平的影响[J]. 罗倩;杨伟.新疆医科大学学报,2025(04)

753．52.阿尔茨海默病病理机制阐释及创新药物研发策略[J]. 李洋.中国药物与临床,2025(05)

754．补肾填精方联合甘露特钠及早期认知康复训练治疗轻中度肾精亏虚型阿尔茨海默病患者的临床研究[J]. 李春雷;周海涛;李尽义;任应国;樊书领.中国合理用药探索,2024(10)

755．补阳还五汤联合电针神庭、百会对阿尔茨海默病患者认知功能及日常生活能力的影响[J]. 孙情;高燕玲;苏清岩;陈晓枫;程熙;戴清月;卢金华;陈星.中国老年保健医学,2024(01)

756．阿尔茨海默病作用机制研究进展与治疗[J]. 仲丽丽;赵秦妍;路鑫;倪雪妍;张静;刘彤慧;刘宏.中医药学报,2023(11)

757．伴有GRN基因突变的语义性痴呆1例[J]. 陈淳淳;朱飞奇;许春燕;邱国真;郭启雯;李嘉文.阿尔茨海默病及相关病杂志,2023(02)

758．经颅磁刺激联合药物治疗阿尔茨海默病的疗效及对认知功能、精神行为症状、AD7c-NTP、5-HT、ACh水平的影响[J]. 李冬梅;敖琦;任胜达.分子诊断与治疗杂志,2025(04)

759．联用甘露特钠对轻中度阿尔茨海默病患者精神行为症状的疗效研究[J]. 魏红辉;孙宁宁;王越;李洋;张滢.中国新药与临床杂志,2024(09)

760．去氢骆驼蓬碱改善阿尔茨海默病作用及其机制研究进展[J]. 仇念壮;张猛;李玫;郭天洋;吕玉丽;张雪辉;王浩.医药导报,2024(06)

761．阿立哌唑治疗阿尔茨海默病伴精神障碍患者的血药浓度监测分析[J]. 周哲明;李芳;易庆;简清勇.中国药物与临床,2025(02)

762．甘露特钠联合利斯的明治疗路易体痴呆1例[J]. 王文婷;毕新婕;陈鸿旭;邵亚丫;张赛;王阳;郝永慈;焉双梅;张婷;郎依琳;顾平.国际老年医学杂志,2022(06)

763．趣味性康复训练在轻中度阿尔茨海默病患者中的应用效果[J]. 马瑶;赵松青;张坦;韦梅.中国医药导报,2024(16)

764．黄连解毒汤及其自沉淀研究进展及前景[J]. 陈燕;李倩;杨新荣;伍文彬;靳子明.辽宁中医药大学学报,2023(07)

765．记忆门诊痴呆前驱期患者轻度行为障碍及照料者负担[J]. 张启文;邓婧;罗环跃;王丽.精神医学杂志,2022(06)

766．耳穴揿针治疗脑卒中后认知障碍的临床研究[D]. 胡浩.安徽中医药大学,2023

767．基于网络药理学、分子对接与动物实验探究百合地黄汤治疗阿尔茨海默病的作用机制[J]. 贾铷;周小如;陈燕;张淑玲;赖兆铠;王玉露.中国现代应用药学,2024(08)

768．以“反复偷盗”为首发症状的老年痴呆[J]. 陈周玲;刘石梅;段新;杨铭哲.国际精神病学杂志,2025(02)

769．甘露特钠联合多奈哌齐治疗阿尔茨海默病的临床研究[J]. 王云霞;李旺俊.现代药物与临床,2022(10)

770．甘露特钠对慢性癫痫大鼠认知功能障碍的影响[J]. 谢懂君;吴旭玲;董楝;余彩遥;彭爽;刘瑛;叶兰;冯占辉.中国神经精神疾病杂志,2023(06)

771．脑深部电刺激联合甘露特钠治疗阿尔茨海默病的疗效及对血清趋化因子CX3CL1及ApoE4水平的影响[J]. 罗倩;杨伟.新疆医科大学学报,2025(04)

772．甘露特钠对轻中度阿尔茨海默病患者认知水平和生活质量的影响[J]. 王顺旺;王慧娟;王长明.罕少疾病杂志,2023(11)

773．知信行模式干预在卵巢癌术后患者中的应用效果[J]. 晁蕊停;杨秀娟;申敏;蒋义娜.癌症进展,2023(05)

774．甘露特钠改善经皮冠状动脉介入治疗后急性进展的阿尔茨海默病1例[J]. 邢梦娅.国际老年医学杂志,2023(01)

775．甘露特钠联合多奈哌齐治疗轻度阿尔茨海默病的疗效[J]. 史璐行;刘巧玲;钱雪芬;王全懂.中国老年学杂志,2022(19)

776．罗非鱼鱼头蛋白肽和核桃蛋白肽协同改善小鼠认知障碍的作用及其机理研究[D]. 吉君.海南大学,2022

777．高压氧联合多奈哌齐治疗阿尔茨海默病疗效及对血清humanin和内皮素1水平的影响[J]. 沈丽丽;徐杰.中华航海医学与高气压医学杂志,2024(06)

778．陈保星,李会朋,王国华,等.覆膜支架腔内隔绝术对Stanford B型主动脉夹层患者血管炎症及心肺功能的改善作用[J].中国临床医生杂志.2025,53(1).

779．罗刚,丁金火,叶雷,等.老年StanfordB型主动脉夹层患者胸主动脉腔内修复术干预时间对术后恢复及预后的影响[J].中国老年学杂志.2024,44(24).

780．胡伟强.熊果酸锂对AD小鼠的认知功能影响及其机制研究[D].2024.

781．刘月阳,姚阳,李佳音,等.以培养药学创新型人才为靶标的药理学教学改革探索[J].化工管理.2024,(32).

782．刘田,杨荣礼,韩慧萍.血清Aβ1-42、Bcl-2预测老年人认知功能障碍进展为阿尔茨海默病的价值[J].实用老年医学.2024,38(6).

783．李虹辰,陶利军.术后认知功能障碍的炎症病因学研究进展[J].现代医学与健康研究（电子版）.2023,7(18).